Publikationen
Hier finden Sie alle nationalen und internationalen Fachveröffentlichungen der NAKO Gesundheitsstudie.
5565830
2024
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22UB4S5TUG%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stein%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-23%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStein%20J%2C%20Pabst%20A%2C%20Berger%20K%2C%20et%20al.%20Mental%20health%20of%20individuals%20with%20pre-existing%20mental%20illnesses%20at%20the%20beginning%20of%20the%20COVID-19%20pandemic%3A%20results%20of%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EFront%20Public%20Health%3C%5C%2Fi%3E.%202024%3B12%3A1451631.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffpubh.2024.1451631%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffpubh.2024.1451631%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mental%20health%20of%20individuals%20with%20pre-existing%20mental%20illnesses%20at%20the%20beginning%20of%20the%20COVID-19%20pandemic%3A%20results%20of%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janine%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Janka%22%2C%22lastName%22%3A%22Massag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Theres%22%2C%22lastName%22%3A%22Huemer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Bohmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Hebestreit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%20C.%22%2C%22lastName%22%3A%22Fuhr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Jaskulski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannah%22%2C%22lastName%22%3A%22Stocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20German%20National%20Cohort%20%28NAKO%29%20Consortium%22%7D%5D%2C%22abstractNote%22%3A%22Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20COVID-19%20pandemic%20prompted%20a%20range%20of%20studies%20on%20mental%20health%2C%20with%20mixed%20results.%20While%20numerous%20studies%20reported%20worsened%20conditions%20in%20individuals%20with%20pre-existing%20mental%20disorders%2C%20others%20showed%20resilience%20and%20stability%20in%20mental%20health.%20However%2C%20longitudinal%20data%20focusing%20on%20the%20German%20population%20are%20sparse%2C%20especially%20regarding%20effects%20of%20age%20and%20pre-existing%20mental%20disorders%20during%20the%20early%20stages%20of%20the%20pandemic.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20assess%20the%20interplay%20between%20psychiatric%20history%2C%20age%2C%20and%20the%20timing%20of%20the%20pandemic%2C%20with%20a%20focus%20on%20understanding%20how%20these%20factors%20relate%20to%20the%20severity%20of%20depression%20and%20anxiety%20symptoms.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Exploratory%20analyses%20were%20based%20on%20135%2C445%20individuals%20aged%2020%5Cu201372%5Cu2009years%20from%20the%20German%20National%20Cohort%20%28NAKO%29.%20Depressive%20and%20anxiety%20symptoms%20were%20assessed%20before%20and%20after%20the%20first%20wave%20of%20the%20pandemic.%20Inferential%20statistical%20analyses%20and%20negative%20binomial%20regression%20models%20were%20calculated.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Persons%20with%20a%20self-reported%20psychiatric%20history%20exhibited%20comparable%20levels%20of%20depression%20and%20anxiety%20symptom%20severity%20after%20the%20first%20wave%20of%20the%20pandemic%20compared%20to%20the%20time%20before.%20In%20contrast%2C%20individuals%20without%20a%20psychiatric%20history%2C%20particularly%20those%20in%20their%2020s%20to%2040s%2C%20experienced%20an%20increase%20in%20mental%20health%20symptom%20severity%20during%20the%20first%20wave%20of%20the%20pandemic.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Limitations%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Analyses%20focuses%20on%20the%20first%20wave%20of%20the%20pandemic%2C%20leaving%20the%20long-term%20mental%20health%20effects%20unexplored.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Future%20research%20should%20consider%20age-specific%20and%20mental-health-related%20factors%20when%20addressing%20global%20health%20crises.%20Additionally%2C%20it%20is%20important%20to%20explore%20factors%20influencing%20resilience%20and%20adaptation%2C%20aiming%20to%20develop%20targeted%20interventions%20and%20informed%20policies%20for%20effective%20mental%20health%20management%20during%20pandemics.%22%2C%22date%22%3A%222024-9-23%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffpubh.2024.1451631%22%2C%22ISSN%22%3A%222296-2565%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffpubh.2024.1451631%5C%2Ffull%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-10-04T16%3A03%3A43Z%22%7D%7D%2C%7B%22key%22%3A%22RMKIL5GV%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22M%5Cu00f6ller%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EM%26%23xF6%3Bller%20H%2C%20Graf%20R%2C%20Schmitt%20J%2C%20et%20al.%20SPINEPS%26%23x2014%3Bautomatic%20whole%20spine%20segmentation%20of%20T2-weighted%20MR%20images%20using%20a%20two-phase%20approach%20to%20multi-class%20semantic%20and%20instance%20segmentation.%20%3Ci%3EEur%20Radiol%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-024-11155-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-024-11155-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SPINEPS%5Cu2014automatic%20whole%20spine%20segmentation%20of%20T2-weighted%20MR%20images%20using%20a%20two-phase%20approach%20to%20multi-class%20semantic%20and%20instance%20segmentation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%22%2C%22lastName%22%3A%22M%5Cu00f6ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Graf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joachim%22%2C%22lastName%22%3A%22Schmitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Keinert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%22%2C%22lastName%22%3A%22Sch%5Cu00f6n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matan%22%2C%22lastName%22%3A%22Atad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjany%22%2C%22lastName%22%3A%22Sekuboyina%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Streckenbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Kofler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kroencke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Bette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Endemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bjoern%22%2C%22lastName%22%3A%22Menze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rueckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20S.%22%2C%22lastName%22%3A%22Kirschke%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Introducing%20SPINEPS%2C%20a%20deep%20learning%20method%20for%20semantic%20and%20instance%20segmentation%20of%2014%20spinal%20structures%20%28ten%20vertebra%20substructures%2C%20intervertebral%20discs%2C%20spinal%20cord%2C%20spinal%20canal%2C%20and%20sacrum%29%20in%20whole-body%20sagittal%20T2-weighted%20turbo%20spin%20echo%20images.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20and%20methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20local%20ethics%20committee-approved%20study%20utilized%20a%20public%20dataset%20%28train%5C%2Ftest%20179%5C%2F39%20subjects%2C%20137%20female%29%2C%20a%20German%20National%20Cohort%20%28NAKO%29%20subset%20%28train%5C%2Ftest%201412%5C%2F65%20subjects%2C%20mean%20age%2053%2C%20694%20female%29%2C%20and%20an%20in-house%20dataset%20%28test%2010%20subjects%2C%20mean%20age%2070%2C%205%20female%29.%20SPINEPS%20is%20a%20semantic%20segmentation%20model%2C%20followed%20by%20a%20sliding%20window%20approach%20utilizing%20a%20second%20model%20to%20create%20instance%20masks%20from%20the%20semantic%20ones.%20Segmentation%20evaluation%20metrics%20included%20the%20Dice%20score%20and%20average%20symmetrical%20surface%20distance%20%28ASSD%29.%20Statistical%20significance%20was%20assessed%20using%20the%20Wilcoxon%20signed-rank%20test.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20On%20the%20public%20dataset%2C%20SPINEPS%20outperformed%20a%20nnUNet%20baseline%20on%20every%20structure%20and%20metric%20%28e.g.%2C%20an%20average%20over%20vertebra%20instances%3A%20dice%200.933%20vs%200.911%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20p%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3C%5Cu20090.001%2C%20ASSD%200.21%20vs%200.435%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20p%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3C%5Cu20090.001%29.%20SPINEPS%20trained%20on%20automated%20annotations%20of%20the%20NAKO%20achieves%20an%20average%20global%20Dice%20score%20of%200.918%20on%20the%20combined%20NAKO%20and%20in-house%20test%20split.%20Adding%20the%20training%20data%20from%20the%20public%20dataset%20outperforms%20this%20%28average%20instance-wise%20Dice%20score%20over%20the%20vertebra%20substructures%200.803%20vs%200.778%2C%20average%20global%20Dice%20score%200.931%20vs%200.918%29.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20SPINEPS%20offers%20segmentation%20of%2014%20spinal%20structures%20in%20T2w%20sagittal%20images.%20It%20provides%20a%20semantic%20mask%20and%20an%20instance%20mask%20separating%20the%20vertebrae%20and%20intervertebral%20discs.%20This%20is%20the%20first%20publicly%20available%20algorithm%20to%20enable%20this%20segmentation.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Key%20Points%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Question%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20No%20publicly%20available%20automatic%20approach%20can%20yield%20semantic%20and%20instance%20segmentation%20masks%20for%20the%20whole%20spine%20%28including%20posterior%20elements%29%20in%20T2-weighted%20sagittal%20TSE%20images%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Findings%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Segmenting%20semantically%20first%20and%20then%20instance-wise%20outperforms%20a%20baseline%20trained%20directly%20on%20instance%20segmentation.%20The%20developed%20model%20produces%20high-resolution%20MRI%20segmentations%20for%20the%20whole%20spine%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Clinical%20relevance%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20study%20introduces%20an%20automatic%20approach%20to%20whole%20spine%20segmentation%2C%20including%20posterior%20elements%2C%20in%20arbitrary%20fields%20of%20view%20T2w%20sagittal%20MR%20images%2C%20enabling%20easy%20biomarker%20extraction%2C%20automatic%20localization%20of%20pathologies%20and%20degenerative%20diseases%2C%20and%20quantifying%20analyses%20as%20downstream%20research%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00330-024-11155-y%22%2C%22ISSN%22%3A%221432-1084%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00330-024-11155-y%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-10-31T08%3A45%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22BMWUJYHC%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A14474791%2C%22username%22%3A%22Louisa_Goldbach%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Flouisa_goldbach%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Berger%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBerger%20K%2C%20Baurecht%20H%2C%20Stein%20M%2C%20et%20al.%20SoccHealth%3A%20a%20health%20status%20examination%20of%20former%20professional%20football%20%28soccer%29%20players%20within%20the%20German%20National%20Cohort.%20%3Ci%3EBMJ%20Open%20Sport%20Exerc%20Med%3C%5C%2Fi%3E.%202024%3B10%284%29%3Ae002228.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjsem-2024-002228%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjsem-2024-002228%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SoccHealth%3A%20a%20health%20status%20examination%20of%20former%20professional%20football%20%28soccer%29%20players%20within%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansjoerg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Weisser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kuss%22%2C%22lastName%22%3A%22Oliver%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Micolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Meyer%22%7D%5D%2C%22abstractNote%22%3A%22The%20long-term%20health%20effects%20of%20football%20%28soccer%29%20have%20received%20significant%20attention%20in%20recent%20years.%20While%20brain%20health%20is%20currently%20the%20focus%20of%20this%20interest%2C%20potential%20long-term%20risks%20or%20benefits%20related%20to%20cardiovascular%20and%20metabolic%20diseases%20and%20cancer%20are%20also%20of%20interest%20to%20sports%20medicine%20professionals.%20However%2C%20studies%20assessing%20the%20overall%20health%20risks%20for%20professional%20football%20players%20remain%20scarce.%20We%20introduce%20%5Cu2018SoccHealth%5Cu2019%2C%20a%20satellite%20project%20to%20the%20German%20National%20Cohort%20%28NAKO%29%2C%20Germany%5Cu2019s%20largest%20population-based%20cohort%20study.%20SoccHealth%20examined%20348%20former%20professional%20football%20players%20aged%2040%5Cu201369%20using%20the%20infrastructure%20and%20comprehensive%20examination%20programme%20of%20NAKO.%20The%20German%20Statutory%20Accidental%20Insurance%20for%20Professional%20Athletes%20identified%20and%20invited%20male%20players%2C%20while%20female%20players%20were%20recruited%20among%20former%20national%20team%20members.%20Details%20of%20the%20examination%20programme%20and%20the%20sociodemographic%20and%20career-related%20characteristics%20of%20the%20participants%20are%20described.%20The%20identical%20examination%20programme%20for%20the%20NAKO%20participants%20provides%20the%20opportunity%20to%20draw%20general%20population%20controls%20according%20to%20various%20definitions%20and%20focus%20on%20the%20respective%20research%20question%20to%20be%20analysed.%20This%20report%20delineates%20one%20approach%20to%20evaluate%20the%20long-term%20health%20effects%20of%20football%20across%20a%20broad%20range%20of%20diseases.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjsem-2024-002228%22%2C%22ISSN%22%3A%222055-7647%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmjopensem.bmj.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1136%5C%2Fbmjsem-2024-002228%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-10-30T13%3A20%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22CILGFKGY%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Callhoff%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECallhoff%20J%2C%20Berger%20K%2C%20Albrecht%20K%2C%20Strangfeld%20A.%20Depression%2C%20anxiety%20and%20cognitive%20function%20in%20persons%20with%20inflammatory%20rheumatic%20diseases%3A%20cross-sectional%20results%20from%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3ERMD%20Open%3C%5C%2Fi%3E.%202024%3B10%284%29%3Ae004808.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Frmdopen-2024-004808%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Frmdopen-2024-004808%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Depression%2C%20anxiety%20and%20cognitive%20function%20in%20persons%20with%20inflammatory%20rheumatic%20diseases%3A%20cross-sectional%20results%20from%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Callhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katinka%22%2C%22lastName%22%3A%22Albrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Strangfeld%22%7D%5D%2C%22abstractNote%22%3A%22Objective%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20assess%20the%20presence%20of%20mental%20health%20disorders%20in%20persons%20with%20rheumatoid%20arthritis%20%28RA%29%2C%20ankylosing%20spondylitis%20%28AS%29%2C%20psoriatic%20arthritis%20%28PsA%29%2C%20systemic%20lupus%20erythematosus%20%28SLE%29%20and%20Sj%5Cu00f6gren%5Cu2019s%20disease%20%28SjD%29%20%28all%3A%20inflammatory%20rheumatic%20disease%2C%20iRMD%29%20in%20a%20population-based%20cohort.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Baseline%20data%20from%20101%5Cu2009601%20participants%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20were%20analysed.%20Self-reported%20physician%5Cu2019s%20diagnoses%20of%20depression%20and%20anxiety%2C%20the%20depression%20scale%20of%20the%20Patient%20Health%20Questionnaire%20%28PHQ-9%29%2C%20the%20Generalised%20Anxiety%20Disorder%20Symptoms%20Scale%20%28GAD-7%29%2C%20the%20depression%20section%20of%20the%20Mini-International%20Neuropsychiatric%20Interview%20%28MINI%29%20and%20cognitive%20tests%20on%20memory%20and%20executive%20functions%20were%20analysed.%20Results%20of%20participants%20with%20iRMD%20were%20compared%20with%20participants%20with%20osteoarthritis%20%28OA%29%2C%20stratified%20by%20age%20and%20sex.%20Cognitive%20function%20was%20described%20for%20iRMD%20and%20OA%20using%20a%20linear%20regression%20model%2C%20adjusted%20for%20sex%20and%20education.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%3D3257%20participants%20%283.2%25%29%20had%20an%20iRMD%20%282.3%25%20RA%2C%200.6%25%20AS%2C%200.5%25%20PsA%2C%200.2%25%20SLE%2C%200.1%25%20SjD%29%20and%20n%3D24%20030%20%2824%25%29%20had%20OA.%20Physicians%5Cu2019%20diagnoses%20of%20depression%20%2826%25%20vs%2021%25%29%2C%20anxiety%20%2815%25%20vs%2011%25%29%2C%20current%20depressive%20%28PHQ-9%20%5Cu226510%3A%2013%25%20vs%209.0%25%29%20and%20anxiety%20symptoms%20%28GAD-7%20%5Cu226510%3A%208.6%25%20vs%205.8%25%29%20were%20more%20frequent%20in%20iRMDs%20compared%20with%20OA.%20In%20all%20age%20groups%2C%20women%20were%20more%20often%20affected%20than%20men.%20Linear%20regression%20models%20showed%20no%20differences%20in%20neuropsychological%20test%20results%20between%20iRMD%20and%20OA.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Individuals%20with%20iRMD%20frequently%20experience%20mental%20disorders.%20The%20study%20provides%20an%20assessment%20of%20both%20self-report%20and%20test-based%20occurrences%20in%20this%20group.%20Depression%20and%20anxiety%20are%20more%20frequent%20in%20iRMD%20compared%20with%20OA%2C%20whereas%20levels%20of%20cognitive%20dysfunction%20were%20comparable.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1136%5C%2Frmdopen-2024-004808%22%2C%22ISSN%22%3A%222056-5933%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Frmdopen.bmj.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1136%5C%2Frmdopen-2024-004808%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-10-30T12%3A42%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22U5TQQC45%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gottschalk%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EGottschalk%20S%2C%20K%26%23xF6%3Bnig%20HH%2C%20Weber%20A%2C%20et%20al.%20Costs%20associated%20with%20insufficient%20physical%20activity%20in%20Germany%3A%20cross-sectional%20results%20from%20the%20baseline%20examination%20of%20the%20German%20national%20cohort%20%28NAKO%29.%20%3Ci%3EEur%20J%20Health%20Econ%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10198-024-01697-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10198-024-01697-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Costs%20associated%20with%20insufficient%20physical%20activity%20in%20Germany%3A%20cross-sectional%20results%20from%20the%20baseline%20examination%20of%20the%20German%20national%20cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Gottschalk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Helmut%22%2C%22lastName%22%3A%22K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20F.%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Flexeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Dorrn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leon%22%2C%22lastName%22%3A%22Klimeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Teresa%20L.%22%2C%22lastName%22%3A%22Seum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Dams%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Insufficient%20physical%20activity%20%28PA%29%20is%20a%20leading%20risk%20factor%20for%20non-communicable%20diseases%20posing%20a%20significant%20economic%20burden%20to%20healthcare%20systems%20and%20societies.%20The%20study%20aimed%20to%20examine%20the%20differences%20in%20healthcare%20and%20indirect%20costs%20between%20sufficient%20and%20insufficient%20PA%20and%20the%20cost%20differences%20between%20PA%20intensity%20groups.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20cross-sectional%20analysis%20was%20based%20on%20data%20from%20157%2C648%20participants%20in%20the%20baseline%20examination%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20study.%20Healthcare%20and%20indirect%20costs%20were%20calculated%20based%20on%20self-reported%20information%20on%20health-related%20resource%20use%20and%20productivity%20losses.%20PA%20in%20the%20domains%20leisure%2C%20transport%2C%20and%20work%20was%20assessed%20by%20the%20Global%20Physical%20Activity%20Questionnaire%20and%20categorized%20into%20sufficient%5C%2Finsufficient%20and%20intensity%20levels%20%28very%20low%5C%2Flow%5C%2Fmedium%5C%2Fhigh%29%20based%20on%20PA%20recommendations%20of%20the%20World%20Health%20Organization.%20Two-part%20models%20adjusted%20for%20relevant%20covariates%20were%20used%20to%20estimate%20mean%20costs%20for%20PA%20groups.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20and%20conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Insufficiently%20active%20people%20had%20higher%20average%20annual%20healthcare%20costs%20%28%5Cu0394%20%5Cu20ac188%2C%2095%25%20CI%20%5B64%2C%20311%5D%29%20and%20healthcare%20plus%20indirect%20costs%20%28%5Cu0394%20%5Cu20ac482%2C%2095%25%20CI%20%5B262%2C%20702%5D%29%20compared%20to%20sufficiently%20active%20people.%20The%20difference%20was%20especially%20evident%20in%20the%20population%20aged%2060%5Cu2009%2B%5Cu2009years%20and%20when%20considering%20only%20leisure%20PA.%20An%20inverse%20association%20was%20observed%20between%20leisure%20PA%20and%20costs%2C%20whereas%20a%20direct%20association%20was%20found%20between%20PA%20at%20work%20and%20costs.%20Adjusting%20for%20the%20number%20of%20comorbidities%20reduced%20the%20differences%20between%20activity%20groups%2C%20but%20the%20trend%20persisted.%20The%20association%20between%20PA%20and%20costs%20differed%20in%20direction%20between%20PA%20domains.%20Future%20research%20may%20provide%20further%20insight%20into%20the%20temporal%20relationship%20between%20PA%20and%20costs.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10198-024-01697-9%22%2C%22ISSN%22%3A%221618-7598%2C%201618-7601%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs10198-024-01697-9%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A06%3A35Z%22%7D%7D%2C%7B%22key%22%3A%222B758ZW9%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Graf%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EGraf%20R%2C%20Platzek%20PS%2C%20Riedel%20EO%2C%20et%20al.%20Generating%20synthetic%20high-resolution%20spinal%20STIR%20and%20T1w%20images%20from%20T2w%20FSE%20and%20low-resolution%20axial%20Dixon.%20%3Ci%3EEur%20Radiol%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-024-11047-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00330-024-11047-1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Generating%20synthetic%20high-resolution%20spinal%20STIR%20and%20T1w%20images%20from%20T2w%20FSE%20and%20low-resolution%20axial%20Dixon%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Graf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul-S%5Cu00f6ren%22%2C%22lastName%22%3A%22Platzek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evamaria%20Olga%22%2C%22lastName%22%3A%22Riedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Su%20Hwan%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Lenhart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constanze%22%2C%22lastName%22%3A%22Ramsch%5Cu00fctz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolin%20Johanna%22%2C%22lastName%22%3A%22Paprottka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olivia%20Ruriko%22%2C%22lastName%22%3A%22Kertels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%20Kristian%22%2C%22lastName%22%3A%22M%5Cu00f6ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matan%22%2C%22lastName%22%3A%22Atad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Werner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20Oliver%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%22%2C%22lastName%22%3A%22Wiestler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%20C.%22%2C%22lastName%22%3A%22Paetzold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rueckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Stefan%22%2C%22lastName%22%3A%22Kirschke%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%20To%20generate%20sagittal%20T1-weighted%20fast%20spin%20echo%20%28T1w%20FSE%29%20and%20short%20tau%20inversion%20recovery%20%28STIR%29%20images%20from%20sagittal%20T2-weighted%20%28T2w%29%20FSE%20and%20axial%20T1w%20gradient%20echo%20Dixon%20technique%20%28T1w-Dixon%29%20sequences.%20Materials%20and%20methods%20This%20retrospective%20study%20used%20three%20existing%20datasets%3A%20%5Cu201cStudy%20of%20Health%20in%20Pomerania%5Cu201d%20%28SHIP%2C%203142%20subjects%2C%201.5%20Tesla%29%2C%20%5Cu201cGerman%20National%20Cohort%5Cu201d%20%28NAKO%2C%202000%20subjects%2C%203%20Tesla%29%2C%20and%20an%20internal%20dataset%20%28157%20patients%201.5%5C%2F3%20Tesla%29.%20We%20generated%20synthetic%20sagittal%20T1w%20FSE%20and%20STIR%20images%20from%20sagittal%20T2w%20FSE%20and%20low-resolution%20axial%20T1w-Dixon%20sequences%20based%20on%20two%20successively%20applied%203D%20Pix2Pix%20deep%20learning%20models.%20%5Cu201cPeak%20signal-to-noise%20ratio%5Cu201d%20%28PSNR%29%20and%20%5Cu201cstructural%20similarity%20index%20metric%5Cu201d%20%28SSIM%29%20were%20used%20to%20evaluate%20the%20generated%20image%20quality%20on%20an%20ablations%20test.%20A%20Turing%20test%2C%20where%20seven%20radiologists%20rated%20240%20images%20as%20either%20natively%20acquired%20or%20generated%2C%20was%20evaluated%20using%20misclassi%5Cufb01cation%20rate%20and%20Fleiss%20kappa%20interrater%20agreement.%5CnResults%20Including%20axial%20T1w-Dixon%20or%20T1w%20FSE%20images%20resulted%20in%20higher%20image%20quality%20in%20generated%20T1w%20FSE%20%28PSNR%20%3D%2026.942%2C%20SSIM%20%3D%200.965%29%20and%20STIR%20%28PSNR%20%3D%2028.86%2C%20SSIM%20%3D%200.948%29%20images%20compared%20to%20using%20only%20single%20T2w%20images%20as%20input%20%28PSNR%20%3D%2023.076%5C%2F24.677%20SSIM%20%3D%200.952%5C%2F0.928%29.%20Radiologists%20had%20dif%5Cufb01culty%20identifying%20generated%20images%20%28misclassi%5Cufb01cation%20rate%3A%200.39%20%5Cu00b1%200.09%20for%20T1w%20FSE%2C%200.42%20%5Cu00b1%200.18%20for%20STIR%29%20and%20showed%20low%20interrater%20agreement%20on%20suspicious%20images%20%28Fleiss%20kappa%3A%200.09%20for%20T1w%5C%2FSTIR%29.%5CnConclusions%20Axial%20T1w-Dixon%20and%20sagittal%20T2w%20FSE%20images%20contain%20suf%5Cufb01cient%20information%20to%20generate%20sagittal%20T1w%20FSE%20and%20STIR%20images.%20Clinical%20relevance%20statement%20T1w%20fast%20spin%20echo%20and%20short%20tau%20inversion%20recovery%20can%20be%20retroactively%20added%20to%20existing%20datasets%2C%20saving%20MRI%20time%20and%20enabling%20retrospective%20analysis%2C%20such%20as%20evaluating%20bone%20marrow%20pathologies.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00330-024-11047-1%22%2C%22ISSN%22%3A%221432-1084%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00330-024-11047-1%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A06%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22YS2D4MU4%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A14474865%2C%22username%22%3A%22Pia_Brauer%22%2C%22name%22%3A%22%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Fpia_brauer%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Hajek%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHajek%20A%2C%20Becher%20H%2C%20Brenner%20H%2C%20et%20al.%20Personality%20and%20the%20use%20of%20cancer%20screenings%20-%20Results%20of%20the%20German%20National%20Cohort.%20%3Ci%3EPreventive%20Medicine%20Reports%3C%5C%2Fi%3E.%202024%3B41%3A102677.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.pmedr.2024.102677%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.pmedr.2024.102677%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Personality%20and%20the%20use%20of%20cancer%20screenings%20-%20Results%20of%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Hajek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Verena%22%2C%22lastName%22%3A%22Katzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heike%22%2C%22lastName%22%3A%22Minnerup%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Haug%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Dorrn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolina%20J.%22%2C%22lastName%22%3A%22Klett-Tammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Helmut%22%2C%22lastName%22%3A%22K%5Cu00f6nig%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.pmedr.2024.102677%22%2C%22ISSN%22%3A%2222113355%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2211335524000925%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22RE2JRY68%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kellner%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKellner%20E%2C%20Sekula%20P%2C%20Lipovsek%20J%2C%20et%20al.%20Imaging%20markers%20derived%20from%20MRI-based%20automated%20kidney%20segmentation.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0040%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0040%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Imaging%20markers%20derived%20from%20MRI-based%20automated%20kidney%20segmentation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elias%22%2C%22lastName%22%3A%22Kellner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peggy%22%2C%22lastName%22%3A%22Sekula%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Lipovsek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maximilian%22%2C%22lastName%22%3A%22Russe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harald%22%2C%22lastName%22%3A%22Horbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Nauck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Bette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%20M.%22%2C%22lastName%22%3A%22Heid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22B%5Cu00fcchert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wilfried%22%2C%22lastName%22%3A%22Reichardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Reisert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22K%5Cu00f6ttgen%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2024.0040%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.m2024.0040%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A53Z%22%7D%7D%2C%7B%22key%22%3A%226XCPVC3G%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Mikolajczyk%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMikolajczyk%20R%2C%20Diexer%20S%2C%20Klee%20B%2C%20et%20al.%20Likelihood%20of%20Post-COVID%20Condition%20in%20people%20with%20hybrid%20immunity%3B%20data%20from%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EJournal%20of%20Infection%3C%5C%2Fi%3E.%202024%3B89%282%29%3A106206.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2024.106206%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jinf.2024.106206%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Likelihood%20of%20Post-COVID%20Condition%20in%20people%20with%20hybrid%20immunity%3B%20data%20from%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Diexer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Klee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Pfrommer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Purschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Ahnert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Gabrysch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Gottschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Buck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%20Moreno%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leo%22%2C%22lastName%22%3A%22Panreck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Standl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jinf.2024.106206%22%2C%22ISSN%22%3A%2201634453%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0163445324001403%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22ZKRST5EU%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schmitt%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchmitt%20M%2C%20Ewendt%20F%2C%20Kluttig%20A%2C%20et%20al.%20Smoking%20is%20associated%20with%20increased%20eryptosis%2C%20suicidal%20erythrocyte%20death%2C%20in%20a%20large%20population-based%20cohort.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202024%3B14%281%29%3A3024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-53258-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-53258-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Smoking%20is%20associated%20with%20increased%20eryptosis%2C%20suicidal%20erythrocyte%20death%2C%20in%20a%20large%20population-based%20cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Schmitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franz%22%2C%22lastName%22%3A%22Ewendt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F.%20Bernhard%22%2C%22lastName%22%3A%22Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%22%2C%22lastName%22%3A%22W%5Cu00e4tjen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul-Christian%22%2C%22lastName%22%3A%22B%5Cu00fcrkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriele%20I.%22%2C%22lastName%22%3A%22Stangl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22F%5Cu00f6ller%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Smoking%20has%20multiple%20detrimental%20effects%20on%20health%2C%20and%20is%20a%20major%20preventable%20cause%20of%20premature%20death%20and%20chronic%20disease.%20Despite%20the%20well-described%20effect%20of%20inhaled%20substances%20from%20tobacco%20smoke%20on%20cell%20toxicity%2C%20the%20association%20between%20smoking%20and%20suicidal%20erythrocyte%20death%2C%20termed%20eryptosis%2C%20is%20virtually%20unknown.%20Therefore%2C%20the%20blood%20samples%20of%202023%20participants%20of%20the%20German%20National%20Cohort%20Study%20%28NAKO%29%20were%20analyzed%20using%20flow%20cytometry%20analysis%20to%20determine%20eryptosis%20from%20fluorescent%20annexin%20V-FITC-binding%20to%20phosphatidylserine-exposing%20erythrocytes.%20Blood%20analyses%20were%20complemented%20by%20the%20measurement%20of%20hematologic%20parameters%20including%20red%20blood%20cell%20count%2C%20hematocrit%2C%20hemoglobin%2C%20mean%20corpuscular%20cell%20volume%20%28MCV%29%20and%20mean%20corpuscular%20hemoglobin%20%28MCH%29.%20Eryptosis%20was%20higher%20in%20smokers%20than%20in%20non-%20and%20ex-smokers%2C%20and%20positively%20associated%20with%20the%20number%20of%20cigarettes%20smoked%20daily%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20r%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20090.08%2C%2095%25%20CI%20%5B0.03%2C%200.12%5D%29.%20Interestingly%2C%20despite%20increased%20eryptosis%2C%20smokers%20had%20higher%20red%20blood%20cell%20indices%20than%20non-smokers.%20To%20conclude%2C%20smokers%20were%20characterized%20by%20higher%20eryptosis%20than%20non-smokers%2C%20without%20showing%20any%20obvious%20detrimental%20effect%20on%20classic%20hematological%20parameters.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-024-53258-y%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-024-53258-y%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22LYIGBXIK%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stein%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStein%20MJ%2C%20Fischer%20B%2C%20Bohmann%20P%2C%20et%20al.%20Differences%20in%20anthropometric%20measures%20based%20on%20sex%2C%20age%2C%20and%20health%20status%3A%20Findings%20from%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0016%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0016%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Differences%20in%20anthropometric%20measures%20based%20on%20sex%2C%20age%2C%20and%20health%20status%3A%20Findings%20from%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patricia%22%2C%22lastName%22%3A%22Bohmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolina%20J.%22%2C%22lastName%22%3A%22Klett-Tammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20F.%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%20M.%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2024.0016%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.m2024.0016%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22UX258CLR%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Weber%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWeber%20A%2C%20Van%20Hees%20VT%2C%20Stein%20MJ%2C%20et%20al.%20Large-scale%20assessment%20of%20physical%20activity%20in%20a%20population%20using%20high-resolution%20hip-worn%20accelerometry%3A%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202024%3B14%281%29%3A7927.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-58461-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-58461-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Large-scale%20assessment%20of%20physical%20activity%20in%20a%20population%20using%20high-resolution%20hip-worn%20accelerometry%3A%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20T.%22%2C%22lastName%22%3A%22Van%20Hees%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Ostrzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirko%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Marschollek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%20M.%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Buck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22D%5Cu00f6rr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Flexeder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Hebestreit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20F.%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Large%20population-based%20cohort%20studies%20utilizing%20device-based%20measures%20of%20physical%20activity%20are%20crucial%20to%20close%20important%20research%20gaps%20regarding%20the%20potential%20protective%20effects%20of%20physical%20activity%20on%20chronic%20diseases.%20The%20present%20study%20details%20the%20quality%20control%20processes%20and%20the%20derivation%20of%20physical%20activity%20metrics%20from%20100%20Hz%20accelerometer%20data%20collected%20in%20the%20German%20National%20Cohort%20%28NAKO%29.%20During%20the%202014%20to%202019%20baseline%20assessment%2C%20a%20subsample%20of%20NAKO%20participants%20wore%20a%20triaxial%20ActiGraph%20accelerometer%20on%20their%20right%20hip%20for%20seven%20consecutive%20days.%20Auto-calibration%2C%20signal%20feature%20calculations%20including%20Euclidean%20Norm%20Minus%20One%20%28ENMO%29%20and%20Mean%20Amplitude%20Deviation%20%28MAD%29%2C%20identification%20of%20non-wear%20time%2C%20and%20imputation%2C%20were%20conducted%20using%20the%20R%20package%20GGIR%20version%202.10-3.%20A%20total%20of%2073%2C334%20participants%20contributed%20data%20for%20accelerometry%20analysis%2C%20of%20whom%2063%2C236%20provided%20valid%20data.%20The%20average%20ENMO%20was%2011.7%5Cu2009%5Cu00b1%5Cu20093.7%20m%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20g%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%28milli%20gravitational%20acceleration%29%20and%20the%20average%20MAD%20was%2019.9%5Cu2009%5Cu00b1%5Cu20096.1%20m%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20g%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20Notably%2C%20acceleration%20summary%20metrics%20were%20higher%20in%20men%20than%20women%20and%20diminished%20with%20increasing%20age.%20Work%20generated%20in%20the%20present%20study%20will%20facilitate%20harmonized%20analysis%2C%20reproducibility%2C%20and%20utilization%20of%20NAKO%20accelerometry%20data.%20The%20NAKO%20accelerometry%20dataset%20represents%20a%20valuable%20asset%20for%20physical%20activity%20research%20and%20will%20be%20accessible%20through%20a%20specified%20application%20process.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-024-58461-5%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-024-58461-5%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A05%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22XIH5T3LE%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Caspers%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ECaspers%20S%2C%20Bamberg%20F%2C%20Schlett%20CL%2C%20et%20al.%20Baseline%20MRI%20examination%20in%20the%20NAKO%20Health%20Study%26%23x2014%3Bfindings%20on%20feasibility%2C%20participation%20and%20dropout%20rates%2C%20comfort%2C%20and%20image%20quality.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0151%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2024.0151%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Baseline%20MRI%20examination%20in%20the%20NAKO%20Health%20Study%5Cu2014findings%20on%20feasibility%2C%20participation%20and%20dropout%20rates%2C%20comfort%2C%20and%20image%20quality%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Svenja%22%2C%22lastName%22%3A%22Caspers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffen%22%2C%22lastName%22%3A%22Ringhof%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochen%20G.%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22R%5Cu00fcdebusch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pavl%5Cu00edna%22%2C%22lastName%22%3A%22Mikl%5Cu00e1nkov%5Cu00e1%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nora%22%2C%22lastName%22%3A%22Bittner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Jockwitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Forsting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Hosten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolph%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kroenke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2024.0151%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.m2024.0151%22%2C%22collections%22%3A%5B%223EUJI4M8%22%5D%2C%22dateModified%22%3A%222024-09-12T12%3A03%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22EYB7E2LQ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Becher%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBecher%20H%2C%20Krist%20L%2C%20Menzel%20J%2C%20et%20al.%20Music-Making%20and%20Depression%20and%20Anxiety%20Before%20and%20During%20the%20COVID-19%20Pandemic%26%23x2014%3BResults%20From%20the%20NAKO%20Cohort%20Study%20in%20Germany.%20%3Ci%3EInt%20J%20Public%20Health%3C%5C%2Fi%3E.%202024%3B69%3A1606993.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606993%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606993%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Music-Making%20and%20Depression%20and%20Anxiety%20Before%20and%20During%20the%20COVID-19%20Pandemic%5Cu2014Results%20From%20the%20NAKO%20Cohort%20Study%20in%20Germany%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliane%22%2C%22lastName%22%3A%22Menzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabel%22%2C%22lastName%22%3A%22Fernholz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunter%22%2C%22lastName%22%3A%22Kreutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Weikert%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20investigate%20the%20association%20of%20musical%20activity%20with%20mental%20health%20during%20the%20COVID-19%20pandemic.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20total%20of%203%2C666%20participants%20reported%20their%20musical%20activity%20before%20and%20mental%20health%20indicators%20before%20and%20during%20the%20pandemic.%20Depression%20was%20assessed%20with%20the%20Patient%20Health%20Questionnaire%2C%20anxiety%20with%20the%20Generalized%20Anxiety%20Disorder%20scale.%20The%20association%20between%20mental%20health%20scores%20and%20musical%20activities%20was%20investigated%20using%20linear%20regression.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Within%20the%20last%2012%5Cu00a0months%2C%2022.1%25%20of%20the%20participants%20reported%20musical%20activity%20%2815.1%25%20singing%2C%2014.5%25%20playing%20an%20instrument%29.%20Individuals%20with%20frequent%20singing%20as%20their%20main%20musical%20activity%20had%20higher%20scores%20before%20the%20pandemic%20than%20non-musicians%20and%20the%20worsening%20during%20the%20pandemic%20was%20more%20pronounced%20compared%20to%20non-musicians.%20Instrumentalists%20tended%20to%20have%20slightly%20lower%20scores%20than%20non-musicians%20indicating%20a%20possible%20beneficial%20effect%20of%20playing%20an%20instrument%20on%20mental%20health.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20pandemic%20led%20to%20a%20worsening%20of%20mental%20health%2C%20with%20singers%20being%20particularly%20affected.%20Singers%20showed%20poorer%20mental%20health%20before%20the%20pandemic.%20The%20tendency%20for%20instrumentalists%20to%20report%20lower%20depression%20scores%20compared%20to%20non-musicians%20may%20support%20the%20hypothesis%20that%20music-making%20has%20a%20beneficial%20effect%20on%20health.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Fijph.2024.1606993%22%2C%22ISSN%22%3A%221661-8564%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ssph-journal.org%5C%2Farticles%5C%2F10.3389%5C%2Fijph.2024.1606993%5C%2Ffull%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-15T14%3A03%3A03Z%22%7D%7D%2C%7B%22key%22%3A%22GAD4FTM9%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Klinger-K%5Cu00f6nig%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKlinger-K%26%23xF6%3Bnig%20J%2C%20Erhardt%20A%2C%20Streit%20F%2C%20et%20al.%20Childhood%20trauma%20and%20somatic%20and%20mental%20illness%20in%20adulthood%26%23x2014%3Bfindings%20of%20the%20NAKO%20health%20study.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202024.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2023.0225%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2023.0225%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Childhood%20trauma%20and%20somatic%20and%20mental%20illness%20in%20adulthood%5Cu2014findings%20of%20the%20NAKO%20health%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelika%22%2C%22lastName%22%3A%22Erhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maja%20P.%22%2C%22lastName%22%3A%22V%5Cu00f6lker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolina%20J.%22%2C%22lastName%22%3A%22Klett-Tammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Karrasch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Konzok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%20Moreno%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%20T.%22%2C%22lastName%22%3A%22Baune%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2023.0225%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.m2023.0225%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A39%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22RWBB53H2%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nimptsch%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ENimptsch%20K%2C%20Aydin%20EE%2C%20Chavarria%20RFR%2C%20et%20al.%20Pregnancy%20associated%20plasma%20protein-A2%20%28PAPP-A2%29%20and%20stanniocalcin-2%20%28STC2%29%20but%20not%20PAPP-A%20are%20associated%20with%20circulating%20total%20IGF-1%20in%20a%20human%20adult%20population.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202024%3B14%281%29%3A1770.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-52074-8%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-52074-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pregnancy%20associated%20plasma%20protein-A2%20%28PAPP-A2%29%20and%20stanniocalcin-2%20%28STC2%29%20but%20not%20PAPP-A%20are%20associated%20with%20circulating%20total%20IGF-1%20in%20a%20human%20adult%20population%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elif%20Ece%22%2C%22lastName%22%3A%22Aydin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%20Francisco%20Rios%22%2C%22lastName%22%3A%22Chavarria%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Janke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%20N.%22%2C%22lastName%22%3A%22Poy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus%22%2C%22lastName%22%3A%22Oxvig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Steinbrecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20pappalysins%20pregnancy%20associated%20plasma%20protein-A%20%28PAPP-A%29%20and%20-A2%20%28PAPP-A2%29%20act%20as%20proteinases%20of%20insulin-like%20growth%20factor-1%20%28IGF-1%29%20binding%20proteins%2C%20while%20stanniocalcin-2%20%28STC2%29%20was%20identified%20as%20a%20pappalysin%20inhibitor.%20While%20there%20is%20some%20evidence%20from%20studies%20in%20children%20and%20adolescents%2C%20it%20is%20unclear%20whether%20these%20molecules%20are%20related%20to%20concentrations%20of%20IGF-1%20and%20its%20binding%20proteins%20in%20adults.%20We%20investigated%20cross-sectionally%20the%20association%20of%20circulating%20PAPP-A%2C%20PAPP-A2%20and%20STC2%20with%20IGF-1%20and%20its%20binding%20proteins%20%28IGFBPs%29%20in%20394%20adult%20pretest%20participants%20%2820%5Cu201369%5Cu00a0years%29%20of%20the%20German%20National%20Cohort%20Berlin%20North%20study%20center.%20Plasma%20PAPP-A%2C%20PAPP-A2%2C%20total%20and%20free%20IGF-1%2C%20IGFBP-1%2C%20IGFBP-2%2C%20IGFBP-3%2C%20IGFBP-5%20and%20STC2%20were%20measured%20by%20ELISAs.%20The%20associations%20of%20PAPP-A%2C%20PAPP-A2%20and%20STC2%20with%20IGF-1%20or%20IGFBPs%20were%20investigated%20using%20multivariable%20linear%20regression%20analyses%20adjusting%20for%20age%2C%20sex%2C%20body%20mass%20index%20and%20pretest%20phase.%20We%20observed%20significant%20inverse%20associations%20of%20PAPP-A2%20%28difference%20in%20concentrations%20per%200.5%5Cu00a0ng%5C%2FmL%20higher%20PAPP-A2%20levels%29%20with%20total%20IGF-1%20%28%5Cu2212%5Cu20094.3%5Cu00a0ng%5C%2FmL%3B%2095%25%20CI%20%5Cu2212%5Cu20097.0%3B%20%5Cu2212%5Cu20091.6%29%2C%20the%20IGF-1%3AIGFBP-3%20molar%20ratio%20%28%5Cu2212%5Cu20090.34%25%3B%2095%25-CI%20%5Cu2212%5Cu20090.59%3B%20%5Cu2212%5Cu20090.09%29%2C%20but%20not%20free%20IGF-1%20and%20a%20positive%20association%20with%20IGFBP-2%20%2811.9%5Cu00a0ng%5C%2FmL%3B%2095%25%20CI%205.0%3B%2018.8%29.%20PAPP-A%20was%20not%20related%20to%20total%20or%20free%20IGF-1%2C%20but%20positively%20associated%20with%20IGFBP-5.%20STC2%20was%20inversely%20related%20to%20total%20IGF-1%2C%20IGFBP-2%20and%20IGFBP-3%20and%20positively%20to%20IGFBP-1.%20This%20first%20investigation%20of%20these%20associations%20in%20a%20general%20adult%20population%20supports%20the%20hypothesis%20that%20PAPP-A2%20as%20well%20as%20STC2%20play%20a%20role%20for%20IGF-1%20and%20its%20binding%20proteins%2C%20especially%20for%20total%20IGF-1.%20The%20role%20of%20PAPP-A2%20and%20STC2%20for%20health%20and%20disease%20in%20adults%20warrants%20further%20investigation.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-024-52074-8%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-024-52074-8%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A37%3A36Z%22%7D%7D%2C%7B%22key%22%3A%2237QEKNSH%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lange%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELange%20B%2C%20Jaeger%20VK%2C%20Harries%20M%2C%20et%20al.%20Estimates%20of%20protection%20levels%20against%20SARS-CoV-2%20infection%20and%20severe%20COVID-19%20in%20Germany%20before%20the%202022%5C%2F2023%20winter%20season%3A%20the%20IMMUNEBRIDGE%20project.%20%3Ci%3EInfection%3C%5C%2Fi%3E.%202024%3B52%281%29%3A139-153.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs15010-023-02071-2%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs15010-023-02071-2%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Estimates%20of%20protection%20levels%20against%20SARS-CoV-2%20infection%20and%20severe%20COVID-19%20in%20Germany%20before%20the%202022%5C%2F2023%20winter%20season%3A%20the%20IMMUNEBRIDGE%20project%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%20K.%22%2C%22lastName%22%3A%22Jaeger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuela%22%2C%22lastName%22%3A%22Harries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktoria%22%2C%22lastName%22%3A%22R%5Cu00fccker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%22%2C%22lastName%22%3A%22Streeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Blaschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Petersmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Toepfner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Nauck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20J.%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maren%22%2C%22lastName%22%3A%22Dreier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabell%22%2C%22lastName%22%3A%22Von%20Holt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Budde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonia%22%2C%22lastName%22%3A%22Bartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Ortmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc-Andr%5Cu00e9%22%2C%22lastName%22%3A%22Kurosinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Reinhard%22%2C%22lastName%22%3A%22Berner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Borsche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunnar%22%2C%22lastName%22%3A%22Brandhorst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Brinkmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Budde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marek%22%2C%22lastName%22%3A%22Deckena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Geraldine%22%2C%22lastName%22%3A%22Engels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fenzlaff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22H%5Cu00e4rtel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olga%22%2C%22lastName%22%3A%22Hovardovska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Katalinic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katja%22%2C%22lastName%22%3A%22Kehl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirjam%22%2C%22lastName%22%3A%22Kohls%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Kr%5Cu00fcger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristin%20M.%22%2C%22lastName%22%3A%22Meyer-Schlinkmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rosenkranz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22R%5Cu00fcbsamen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Rupp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Sch%5Cu00e4fer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mario%22%2C%22lastName%22%3A%22Schattschneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Schlegtendal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Schlinkert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Schmidbauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai%22%2C%22lastName%22%3A%22Schulze-Wundling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22St%5Cu00f6rk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%22%2C%22lastName%22%3A%22Tiemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theresa%22%2C%22lastName%22%3A%22Winter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Klein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Liese%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Folke%22%2C%22lastName%22%3A%22Brinkmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%20F.%22%2C%22lastName%22%3A%22Ottensmeyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens-Peter%22%2C%22lastName%22%3A%22Reese%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Heuschmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Purpose%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Despite%20the%20need%20to%20generate%20valid%20and%20reliable%20estimates%20of%20protection%20levels%20against%20SARS-CoV-2%20infection%20and%20severe%20course%20of%20COVID-19%20for%20the%20German%20population%20in%20summer%202022%2C%20there%20was%20a%20lack%20of%20systematically%20collected%20population-based%20data%20allowing%20for%20the%20assessment%20of%20the%20protection%20level%20in%20real%20time.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20IMMUNEBRIDGE%20project%2C%20we%20harmonised%20data%20and%20biosamples%20for%20nine%20population-%5C%2Fhospital-based%20studies%20%28total%20number%20of%20participants%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu200933%2C637%29%20to%20provide%20estimates%20for%20protection%20levels%20against%20SARS-CoV-2%20infection%20and%20severe%20COVID-19%20between%20June%20and%20November%202022.%20Based%20on%20evidence%20synthesis%2C%20we%20formed%20a%20combined%20endpoint%20of%20protection%20levels%20based%20on%20the%20number%20of%20self-reported%20infections%5C%2Fvaccinations%20in%20combination%20with%20nucleocapsid%5C%2Fspike%20antibody%20responses%20%28%5Cu201cconfirmed%20exposures%5Cu201d%29.%20Four%20confirmed%20exposures%20represented%20the%20highest%20protection%20level%2C%20and%20no%20exposure%20represented%20the%20lowest.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Most%20participants%20were%20seropositive%20against%20the%20spike%20antigen%3B%2037%25%20of%20the%20participants%5Cu2009%5Cu2265%5Cu200979%5Cu00a0years%20had%20less%20than%20four%20confirmed%20exposures%20%28highest%20level%20of%20protection%29%20and%205%25%20less%20than%20three.%20In%20the%20subgroup%20of%20participants%20with%20comorbidities%2C%2046%5Cu201356%25%20had%20less%20than%20four%20confirmed%20exposures.%20We%20found%20major%20heterogeneity%20across%20federal%20states%2C%20with%204%5Cu201328%25%20of%20participants%20having%20less%20than%20three%20confirmed%20exposures.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Using%20serological%20analyses%2C%20literature%20synthesis%20and%20infection%20dynamics%20during%20the%20survey%20period%2C%20we%20observed%20moderate%20to%20high%20levels%20of%20protection%20against%20severe%20COVID-19%2C%20whereas%20the%20protection%20against%20SARS-CoV-2%20infection%20was%20low%20across%20all%20age%20groups.%20We%20found%20relevant%20protection%20gaps%20in%20the%20oldest%20age%20group%20and%20amongst%20individuals%20with%20comorbidities%2C%20indicating%20a%20need%20for%20additional%20protective%20measures%20in%20these%20groups.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs15010-023-02071-2%22%2C%22ISSN%22%3A%220300-8126%2C%201439-0973%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs15010-023-02071-2%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A37%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22UREHZZHT%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Herbolsheimer%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHerbolsheimer%20F%2C%20Peters%20A%2C%20Wagner%20S%2C%20et%20al.%20Changes%20in%20physical%20activity%20and%20sedentary%20behavior%20during%20the%20first%20COVID-19%20pandemic-%20restrictions%20in%20Germany%3A%20a%20nationwide%20survey%3A%20Running%20head%3A%20physical%20activity%20during%20the%20COVID-19%20restrictions.%20%3Ci%3EBMC%20Public%20Health%3C%5C%2Fi%3E.%202024%3B24%281%29%3A433.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-024-17675-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-024-17675-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Changes%20in%20physical%20activity%20and%20sedentary%20behavior%20during%20the%20first%20COVID-19%20pandemic-%20restrictions%20in%20Germany%3A%20a%20nationwide%20survey%3A%20Running%20head%3A%20physical%20activity%20during%20the%20COVID-19%20restrictions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirko%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana%20K.%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Franzp%5Cu00f6tter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20J.%22%2C%22lastName%22%3A%22Stein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20COVID-19%20pandemic%20restrictions%20posed%20challenges%20to%20maintaining%20healthy%20lifestyles%20and%20physical%20well-being.%20During%20the%20first%20mobility%20restrictions%20from%20March%20to%20mid-July%202020%2C%20the%20German%20population%20was%20advised%20to%20stay%20home%2C%20except%20for%20work%2C%20exercise%2C%20and%20essential%20shopping.%20Our%20objective%20was%20to%20comprehensively%20assess%20the%20impact%20of%20these%20restrictions%20on%20changes%20in%20physical%20activity%20and%20sedentary%20behavior%20to%20identify%20the%20most%20affected%20groups.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Between%20April%2030%2C%202020%2C%20and%20May%2012%2C%202020%2C%20we%20distributed%20a%20COVID-19-specific%20questionnaire%20to%20participants%20of%20the%20German%20National%20Cohort%20%28NAKO%29.%20This%20questionnaire%20gathered%20information%20about%20participants%5Cu2019%20physical%20activity%20and%20sedentary%20behavior%20currently%20compared%20to%20the%20time%20before%20the%20restrictions.%20We%20integrated%20this%20new%20data%20with%20existing%20information%20on%20anxiety%2C%20depressive%20symptoms%2C%20and%20physical%20activity.%20The%20analyses%20focused%20on%20sociodemographic%20factors%2C%20social%20relationships%2C%20physical%20health%2C%20and%20working%20conditions.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Out%20of%20152%2C421%20respondents%2C%20a%20significant%20proportion%20reported%20altered%20physical%20activity%20and%20sedentary%20behavioral%20patterns%20due%20to%20COVID-19%20restrictions.%20Over%20a%20third%20of%20the%20participants%20initially%20meeting%20the%20WHO%5Cu2019s%20physical%20activity%20recommendation%20could%20no%20longer%20meet%20the%20guidelines%20during%20the%20restrictions.%20Participants%20reported%20substantial%20declines%20in%20sports%20activities%20%28mean%20change%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%5Cu2009%3D%5Cu2009-0.38%3B%2095%25%5Cu00a0CI%3A%20-.390%3B%20-.378%3B%20range%20from%20-2%20to%5Cu2009%2B%5Cu20092%29%20and%20reduced%20active%20transportation%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu2009-0.12%3B%2095%25%5Cu00a0CI%3A%20-.126%3B%20-.117%29.%20However%2C%20they%20also%20increased%20recreational%20physical%20activities%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20090.12%3B%2095%25%5Cu00a0CI%3A%20.117%3B%20.126%29%20while%20engaging%20in%20more%20sedentary%20behavior%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20090.24%3B%2095%25%5Cu00a0CI%3A%20.240%3B%20.247%29%20compared%20to%20pre-restriction%20levels.%20Multivariable%20linear%20and%20log-binomial%20regression%20models%20indicated%20that%20younger%20adults%20were%20more%20affected%20by%20the%20restrictions%20than%20older%20adults.%20The%20shift%20to%20remote%20work%2C%20self-rated%20health%2C%20and%20depressive%20symptoms%20were%20the%20factors%20most%20strongly%20associated%20with%20changes%20in%20all%20physical%20activity%20domains%2C%20including%20sedentary%20behavior%2C%20and%20the%20likelihood%20to%20continue%20following%20the%20physical%20activity%20guidelines.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mobility%20patterns%20shifted%20towards%20inactivity%20or%20low-intensity%20activities%20during%20the%20nationwide%20restrictions%20in%20the%20spring%20of%202020%2C%20potentially%20leading%20to%20considerable%20and%20lasting%20health%20risks.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12889-024-17675-y%22%2C%22ISSN%22%3A%221471-2458%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcpublichealth.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12889-024-17675-y%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A36%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22FWQJHYWR%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wiessner%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWiessner%20C%2C%20Licaj%20S%2C%20Klein%20J%2C%20et%20al.%20Health%20Service%20Use%20Among%20Migrants%20in%20the%20German%20National%20Cohort%26%23x2014%3BThe%20Role%20of%20Birth%20Region%20and%20Language%20Skills.%20%3Ci%3EInt%20J%20Public%20Health%3C%5C%2Fi%3E.%202024%3B69%3A1606377.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606377%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2024.1606377%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Health%20Service%20Use%20Among%20Migrants%20in%20the%20German%20National%20Cohort%5Cu2014The%20Role%20of%20Birth%20Region%20and%20Language%20Skills%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wiessner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Licaj%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%22%2C%22lastName%22%3A%22Klein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tilman%22%2C%22lastName%22%3A%22Brand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margit%22%2C%22lastName%22%3A%22Heier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Jaskulski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%5D%2C%22abstractNote%22%3A%22Objective%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20compare%20health%20service%20use%20%28HSU%29%20between%20migrants%20and%20non-migrants%20in%20Germany.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Using%20data%20from%20the%20population-based%20German%20National%20Cohort%20%28NAKO%29%2C%20we%20compared%20the%20HSU%20of%20general%20practitioners%2C%20medical%20specialists%2C%20and%20psychologists%5C%2Fpsychiatrists%20between%20six%20migrant%20groups%20of%20different%20origins%20with%20the%20utilization%20of%20non-migrants.%20A%20latent%20profile%20analysis%20%28LPA%29%20with%20a%20subsequent%20multinomial%20regression%20analysis%20was%20conducted%20to%20characterize%20the%20HSU%20of%20different%20groups.%20Additionally%2C%20separate%20regression%20models%20were%20calculated.%20Both%20analyses%20aimed%20to%20estimate%20the%20direct%20effect%20of%20migration%20background%20on%20HSU.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20LPA%2C%20the%20migrant%20groups%20showed%20no%20relevant%20differences%20compared%20to%20non-migrants%20regarding%20HSU.%20In%20separate%20analyses%2C%20general%20practitioners%20and%20medical%20specialists%20were%20used%20comparably%20to%20slightly%20more%20often%20by%20first-generation%20migrants%20from%20Eastern%20Europe%2C%20Turkey%2C%20and%20resettlers.%20In%20contrast%2C%20the%20use%20of%20psychologists%5C%2Fpsychiatrists%20was%20substantially%20lower%20among%20those%20groups.%20Second-generation%20migrants%20and%20migrants%20from%20Western%20countries%20showed%20no%20differences%20in%20their%20HSU%20compared%20to%20non-migrants.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20observed%20a%20low%20mental%20HSU%20among%20specific%20migrant%20groups%20in%20Germany.%20This%20indicates%20the%20existence%20of%20barriers%20among%20those%20groups%20that%20need%20to%20be%20addressed.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Fijph.2024.1606377%22%2C%22ISSN%22%3A%221661-8564%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ssph-journal.org%5C%2Farticles%5C%2F10.3389%5C%2Fijph.2024.1606377%5C%2Ffull%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A35%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22BHFP7QG4%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Holz%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHolz%20A%2C%20Obi%20N%2C%20Ahrens%20W%2C%20et%20al.%20Childhood%20and%20adolescence%20factors%20and%20multiple%20sclerosis%3A%20results%20from%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EBMC%20Neurol%3C%5C%2Fi%3E.%202024%3B24%281%29%3A123.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12883-024-03620-4%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12883-024-03620-4%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Childhood%20and%20adolescence%20factors%20and%20multiple%20sclerosis%3A%20results%20from%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Holz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Volker%22%2C%22lastName%22%3A%22Harth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolina%20J.%22%2C%22lastName%22%3A%22Klett-Tammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Riedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Hellwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Riemann-Lorenz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Heesen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Multiple%20Sclerosis%20%28MS%29%20represents%20the%20most%20common%20inflammatory%20neurological%20disease%20causing%20disability%20in%20early%20adulthood.%20Childhood%20and%20adolescence%20factors%20might%20be%20of%20relevance%20in%20the%20development%20of%20MS.%20We%20aimed%20to%20investigate%20the%20association%20between%20various%20factors%20%28e.g.%2C%20prematurity%2C%20breastfeeding%2C%20daycare%20attendance%2C%20weight%20history%29%20and%20MS%20risk.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20from%20the%20baseline%20assessment%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20were%20used%20to%20calculate%20adjusted%20hazard%20ratios%20%28HR%29%20and%2095%25%20confidence%20intervals%20%28CI%29%20for%20the%20association%20between%20childhood%20and%20adolescence%20factors%20and%20risk%20of%20MS.%20Analyses%20stratified%20by%20sex%20were%20conducted.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Among%20a%20total%20of%20204%2C273%20participants%2C%20858%20reported%20an%20MS%20diagnosis.%20Male%20sex%20was%20associated%20with%20a%20decreased%20MS%20risk%20%28HR%200.48%3B%2095%25%20CI%200.41%5Cu20130.56%29%2C%20while%20overweight%20%28HR%202.03%3B%2095%25%20CI%201.41%5Cu20132.94%29%20and%20obesity%20%28HR%201.89%3B%2095%25%20CI%201.02%5Cu20133.48%29%20at%2018%5Cu00a0years%20of%20age%20compared%20to%20normal%20weight%20were%20associated%20with%20increased%20MS%20risk.%20Having%20been%20breastfed%20for%5Cu2009%5Cu2264%5Cu20094%5Cu00a0months%20was%20associated%20with%20a%20decreased%20MS%20risk%20in%20men%20%28HR%200.59%3B%2095%25%20CI%200.40%5Cu20130.86%29%20compared%20to%20no%20breastfeeding.%20No%20association%20with%20MS%20risk%20was%20observed%20for%20the%20remaining%20factors.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Apart%20from%20overweight%20and%20obesity%20at%20the%20age%20of%2018%5Cu00a0years%2C%20we%20did%20not%20observe%20considerable%20associations%20with%20MS%20risk.%20The%20proportion%20of%20cases%20that%20can%20be%20explained%20by%20childhood%20and%20adolescence%20factors%20examined%20in%20this%20study%20was%20low.%20Further%20investigations%20of%20the%20association%20between%20the%20onset%20of%20overweight%20and%20obesity%20in%20childhood%20and%20adolescence%20and%20its%20interaction%20with%20physical%20activity%20and%20MS%20risk%20seem%20worthwhile.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12883-024-03620-4%22%2C%22ISSN%22%3A%221471-2377%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcneurol.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12883-024-03620-4%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A33%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22K95MRY4P%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Methorst%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMethorst%20J.%20Positive%20relationship%20between%20bird%20diversity%20and%20human%20mental%20health%3A%20an%20analysis%20of%20repeated%20cross-sectional%20data.%20%3Ci%3EThe%20Lancet%20Planetary%20Health%3C%5C%2Fi%3E.%202024%3B8%285%29%3Ae285-e296.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2542-5196%2824%2900023-8%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2FS2542-5196%2824%2900023-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Positive%20relationship%20between%20bird%20diversity%20and%20human%20mental%20health%3A%20an%20analysis%20of%20repeated%20cross-sectional%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joel%22%2C%22lastName%22%3A%22Methorst%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2FS2542-5196%2824%2900023-8%22%2C%22ISSN%22%3A%2225425196%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS2542519624000238%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A31%3A31Z%22%7D%7D%2C%7B%22key%22%3A%22VBTF9G7V%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jung%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJung%20M%2C%20Rieder%20H%2C%20Reisert%20M%2C%20et%20al.%20Association%20between%20myosteatosis%20and%20impaired%20glucose%20metabolism%3A%20A%20deep%20learning%20whole%26%23x2010%3Bbody%20magnetic%20resonance%20imaging%20population%20phenotyping%20approach.%20%3Ci%3EJ%20cachexia%20sarcopenia%20muscle%3C%5C%2Fi%3E.%202024%3Ajcsm.13527.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjcsm.13527%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fjcsm.13527%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20myosteatosis%20and%20impaired%20glucose%20metabolism%3A%20A%20deep%20learning%20whole%5Cu2010body%20magnetic%20resonance%20imaging%20population%20phenotyping%20approach%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Jung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%22%2C%22lastName%22%3A%22Rieder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Reisert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Rospleszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Nattenmueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Weiss%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20There%20is%20increasing%20evidence%20that%20myosteatosis%2C%20which%20is%20currently%20not%20assessed%20in%20clinical%20routine%2C%20plays%20an%20important%20role%20in%20risk%20estimation%20in%20individuals%20with%20impaired%20glucose%20metabolism%2C%20as%20it%20is%20associated%20with%20the%20progression%20of%20insulin%20resistance.%20With%20advances%20in%20artificial%20intelligence%2C%20automated%20and%20accurate%20algorithms%20have%20become%20feasible%20to%20fill%20this%20gap.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20this%20retrospective%20study%2C%20we%20developed%20and%20tested%20a%20fully%20automated%20deep%20learning%20model%20using%20data%20from%20two%20prospective%20cohort%20studies%20%28German%20National%20Cohort%20%5BNAKO%5D%20and%20Cooperative%20Health%20Research%20in%20the%20Region%20of%20Augsburg%20%5BKORA%5D%29%20to%20quantify%20myosteatosis%20on%20whole%5Cu2010body%20T1%5Cu2010weighted%20Dixon%20magnetic%20resonance%20imaging%20as%20%281%29%20intramuscular%20adipose%20tissue%20%28IMAT%3B%20the%20current%20standard%29%20and%20%282%29%20quantitative%20skeletal%20muscle%20%28SM%29%20fat%20fraction%20%28SMFF%29.%20Subsequently%2C%20we%20investigated%20the%20two%20measures%20for%20their%20discrimination%20of%20and%20association%20with%20impaired%20glucose%20metabolism%20beyond%20baseline%20demographics%20%28age%2C%20sex%20and%20body%20mass%20index%20%5BBMI%5D%29%20and%20cardiometabolic%20risk%20factors%20%28lipid%20panel%2C%20systolic%20blood%20pressure%2C%20smoking%20status%20and%20alcohol%20consumption%29%20in%20asymptomatic%20individuals%20from%20the%20KORA%20study.%20Impaired%20glucose%20metabolism%20was%20defined%20as%20impaired%20fasting%20glucose%20or%20impaired%20glucose%20tolerance%20%28140%5Cu2013200%5Cu00a0mg%5C%2FdL%29%20or%20prevalent%20diabetes%20mellitus.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Model%20performance%20was%20high%2C%20with%20Dice%20coefficients%20of%20%5Cu22650.81%20for%20IMAT%20and%20%5Cu22650.91%20for%20SM%20in%20the%20internal%20%28NAKO%29%20and%20external%20%28KORA%29%20testing%20sets.%20In%20the%20target%20population%20%28380%20KORA%20participants%3A%20mean%20age%20of%2053.6%5Cu00a0%5Cu00b1%5Cu00a09.2%5Cu00a0years%2C%20BMI%20of%2028.2%5Cu00a0%5Cu00b1%5Cu00a04.9%5Cu00a0kg%5C%2Fm%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%2057.4%25%20male%29%2C%20individuals%20with%20impaired%20glucose%20metabolism%20%28%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3D%5Cu00a0146%3B%2038.4%25%29%20were%20older%20and%20more%20likely%20men%20and%20showed%20a%20higher%20cardiometabolic%20risk%20profile%2C%20higher%20IMAT%20%284.5%5Cu00a0%5Cu00b1%5Cu00a02.2%25%20vs.%203.9%5Cu00a0%5Cu00b1%5Cu00a01.7%25%29%20and%20higher%20SMFF%20%2822.0%5Cu00a0%5Cu00b1%5Cu00a04.7%25%20vs.%2018.9%5Cu00a0%5Cu00b1%5Cu00a03.9%25%29%20compared%20to%20normoglycaemic%20controls%20%28all%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%5Cu2264%5Cu00a00.005%29.%20SMFF%20showed%20better%20discrimination%20for%20impaired%20glucose%20metabolism%20than%20IMAT%20%28area%20under%20the%20receiver%20operating%20characteristic%20curve%20%5BAUC%5D%200.693%20vs.%200.582%2C%2095%25%20confidence%20interval%20%5BCI%5D%20%5B0.06%5Cu20130.16%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3C%5Cu00a00.001%29%20but%20was%20not%20significantly%20different%20from%20BMI%20%28AUC%200.733%20vs.%200.693%2C%2095%25%20CI%20%5B%5Cu22120.09%20to%200.01%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3D%5Cu00a00.15%29.%20In%20univariable%20logistic%20regression%2C%20IMAT%20%28odds%20ratio%20%5BOR%5D%5Cu00a0%3D%5Cu00a01.18%2C%2095%25%20CI%20%5B1.06%5Cu20131.32%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3D%5Cu00a00.004%29%20and%20SMFF%20%28OR%5Cu00a0%3D%5Cu00a01.19%2C%2095%25%20CI%20%5B1.13%5Cu20131.26%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3C%5Cu00a00.001%29%20were%20associated%20with%20a%20higher%20risk%20of%20impaired%20glucose%20metabolism.%20This%20signal%20remained%20robust%20after%20multivariable%20adjustment%20for%20baseline%20demographics%20and%20cardiometabolic%20risk%20factors%20for%20SMFF%20%28OR%5Cu00a0%3D%5Cu00a01.10%2C%2095%25%20CI%20%5B1.01%5Cu20131.19%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3D%5Cu00a00.028%29%20but%20not%20for%20IMAT%20%28OR%5Cu00a0%3D%5Cu00a01.14%2C%2095%25%20CI%20%5B0.97%5Cu20131.33%5D%3B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00a0%3D%5Cu00a00.11%29.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Quantitative%20SMFF%2C%20but%20not%20IMAT%2C%20is%20an%20independent%20predictor%20of%20impaired%20glucose%20metabolism%2C%20and%20discrimination%20is%20not%20significantly%20different%20from%20BMI%2C%20making%20it%20a%20promising%20alternative%20for%20the%20currently%20established%20approach.%20Automated%20methods%20such%20as%20the%20proposed%20model%20may%20provide%20a%20feasible%20option%20for%20opportunistic%20screening%20of%20myosteatosis%20and%2C%20thus%2C%20a%20low%5Cu2010cost%20personalized%20risk%20assessment%20solution.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fjcsm.13527%22%2C%22ISSN%22%3A%222190-5991%2C%202190-6009%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2F10.1002%5C%2Fjcsm.13527%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T12%3A31%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22I9B6KCP3%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Menzel%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMenzel%20J%2C%20Kreutz%20G%2C%20Jabusch%20HC%2C%20et%20al.%20Musical%20activity%20in%20a%20subsample%20of%20the%20German%20National%20Cohort%20study.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202024%3B14%281%29%3A14069.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-64773-3%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-024-64773-3%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Musical%20activity%20in%20a%20subsample%20of%20the%20German%20National%20Cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliane%22%2C%22lastName%22%3A%22Menzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunter%22%2C%22lastName%22%3A%22Kreutz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Christian%22%2C%22lastName%22%3A%22Jabusch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friederike%22%2C%22lastName%22%3A%22Borngr%5Cu00e4ber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabel%22%2C%22lastName%22%3A%22Fernholz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Weikert%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Musical%20activities%20%28MA%29%20such%20as%20singing%2C%20playing%20instruments%2C%20and%20listening%20to%20music%20may%20be%20associated%20with%20health%20benefits.%20However%2C%20evidence%20from%20epidemiological%20studies%20is%20still%20limited.%20This%20study%20aims%20at%20describing%20the%20relation%20between%20MA%20and%20both%20sociodemographic%20and%20health-related%20factors%20in%20a%20cross-sectional%20approach.%20A%20total%20of%206717%20adults%20%2850.3%25%20women%2C%2049.7%25%20men%2C%20median%20age%3A%2051%5Cu00a0years%20%28IQR%2043%5Cu201360%29%20were%20recruited%20from%20the%20study%20center%20Berlin-Mitte%20of%20the%20German%20National%20Cohort%20%28NAKO%29%2C%20a%20population-based%20prospective%20study.%20This%20study%20is%20based%20on%20a%20sample%20randomly%20selected%20from%20the%20population%20registry%20of%20Berlin%2C%20Germany%2C%20aged%2020%20to%2069%5Cu00a0years.%2053%25%20of%20the%20participants%20had%20been%20musically%20active%20at%20least%20once%20in%20their%20life%20%2856.1%25%20women%2C%2043.9%25%20men%29.%20Playing%20keyboard%20instruments%20%2830%25%29%20and%20singing%20%2821%25%29%20were%20the%20most%20frequent%20MA.%20Participants%20listened%20to%20music%20in%20median%2090%5Cu00a0min%20per%20day%20%28IQR%2030.0%5Cu2013150.0%29.%20Musically%20active%20individuals%20were%20more%20likely%20to%20have%20a%20higher%20education%2C%20higher%20alcohol%20consumption%2C%20were%20less%20likely%20to%20be%20physically%20active%2C%20and%20had%20a%20lower%20BMI%20compared%20to%20musically%20inactive%20individuals.%20This%20large%20population-based%20study%20offers%20a%20comprehensive%20description%20of%20demographic%2C%20health%2C%20and%20lifestyle%20characteristics%20associated%20with%20MA.%20Our%20findings%20may%20aid%20in%20assessing%20long-term%20health%20consequences%20of%20MA.%22%2C%22date%22%3A%222024%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-024-64773-3%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-024-64773-3%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-24T15%3A21%3A00Z%22%7D%7D%5D%7D
1.
Stein J, Pabst A, Berger K, et al. Mental health of individuals with pre-existing mental illnesses at the beginning of the COVID-19 pandemic: results of the German National Cohort (NAKO). Front Public Health. 2024;12:1451631. http://doi.org/10.3389/fpubh.2024.1451631
1.
Möller H, Graf R, Schmitt J, et al. SPINEPS—automatic whole spine segmentation of T2-weighted MR images using a two-phase approach to multi-class semantic and instance segmentation. Eur Radiol. 2024. http://doi.org/10.1007/s00330-024-11155-y
1.
Berger K, Baurecht H, Stein M, et al. SoccHealth: a health status examination of former professional football (soccer) players within the German National Cohort. BMJ Open Sport Exerc Med. 2024;10(4):e002228. http://doi.org/10.1136/bmjsem-2024-002228
1.
Callhoff J, Berger K, Albrecht K, Strangfeld A. Depression, anxiety and cognitive function in persons with inflammatory rheumatic diseases: cross-sectional results from the German National Cohort (NAKO). RMD Open. 2024;10(4):e004808. http://doi.org/10.1136/rmdopen-2024-004808
1.
Gottschalk S, König HH, Weber A, et al. Costs associated with insufficient physical activity in Germany: cross-sectional results from the baseline examination of the German national cohort (NAKO). Eur J Health Econ. 2024. http://doi.org/10.1007/s10198-024-01697-9
1.
Graf R, Platzek PS, Riedel EO, et al. Generating synthetic high-resolution spinal STIR and T1w images from T2w FSE and low-resolution axial Dixon. Eur Radiol. 2024. http://doi.org/10.1007/s00330-024-11047-1
1.
Hajek A, Becher H, Brenner H, et al. Personality and the use of cancer screenings - Results of the German National Cohort. Preventive Medicine Reports. 2024;41:102677. http://doi.org/10.1016/j.pmedr.2024.102677
1.
Kellner E, Sekula P, Lipovsek J, et al. Imaging markers derived from MRI-based automated kidney segmentation. Deutsches Ärzteblatt international. 2024. http://doi.org/10.3238/arztebl.m2024.0040
1.
Mikolajczyk R, Diexer S, Klee B, et al. Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). Journal of Infection. 2024;89(2):106206. http://doi.org/10.1016/j.jinf.2024.106206
1.
Schmitt M, Ewendt F, Kluttig A, et al. Smoking is associated with increased eryptosis, suicidal erythrocyte death, in a large population-based cohort. Sci Rep. 2024;14(1):3024. http://doi.org/10.1038/s41598-024-53258-y
1.
Stein MJ, Fischer B, Bohmann P, et al. Differences in anthropometric measures based on sex, age, and health status: Findings from the German National Cohort (NAKO). Deutsches Ärzteblatt international. 2024. http://doi.org/10.3238/arztebl.m2024.0016
1.
Weber A, Van Hees VT, Stein MJ, et al. Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO). Sci Rep. 2024;14(1):7927. http://doi.org/10.1038/s41598-024-58461-5
1.
Caspers S, Bamberg F, Schlett CL, et al. Baseline MRI examination in the NAKO Health Study—findings on feasibility, participation and dropout rates, comfort, and image quality. Deutsches Ärzteblatt international. 2024. http://doi.org/10.3238/arztebl.m2024.0151
1.
Becher H, Krist L, Menzel J, et al. Music-Making and Depression and Anxiety Before and During the COVID-19 Pandemic—Results From the NAKO Cohort Study in Germany. Int J Public Health. 2024;69:1606993. http://doi.org/10.3389/ijph.2024.1606993
1.
Klinger-König J, Erhardt A, Streit F, et al. Childhood trauma and somatic and mental illness in adulthood—findings of the NAKO health study. Deutsches Ärzteblatt international. 2024. http://doi.org/10.3238/arztebl.m2023.0225
1.
Nimptsch K, Aydin EE, Chavarria RFR, et al. Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population. Sci Rep. 2024;14(1):1770. http://doi.org/10.1038/s41598-024-52074-8
1.
Lange B, Jaeger VK, Harries M, et al. Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project. Infection. 2024;52(1):139-153. http://doi.org/10.1007/s15010-023-02071-2
1.
Herbolsheimer F, Peters A, Wagner S, et al. Changes in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey: Running head: physical activity during the COVID-19 restrictions. BMC Public Health. 2024;24(1):433. http://doi.org/10.1186/s12889-024-17675-y
1.
Wiessner C, Licaj S, Klein J, et al. Health Service Use Among Migrants in the German National Cohort—The Role of Birth Region and Language Skills. Int J Public Health. 2024;69:1606377. http://doi.org/10.3389/ijph.2024.1606377
1.
Holz A, Obi N, Ahrens W, et al. Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). BMC Neurol. 2024;24(1):123. http://doi.org/10.1186/s12883-024-03620-4
1.
Methorst J. Positive relationship between bird diversity and human mental health: an analysis of repeated cross-sectional data. The Lancet Planetary Health. 2024;8(5):e285-e296. http://doi.org/10.1016/S2542-5196(24)00023-8
1.
Jung M, Rieder H, Reisert M, et al. Association between myosteatosis and impaired glucose metabolism: A deep learning whole‐body magnetic resonance imaging population phenotyping approach. J cachexia sarcopenia muscle. 2024:jcsm.13527. http://doi.org/10.1002/jcsm.13527
1.
Menzel J, Kreutz G, Jabusch HC, et al. Musical activity in a subsample of the German National Cohort study. Sci Rep. 2024;14(1):14069. http://doi.org/10.1038/s41598-024-64773-3
5565830
2023
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%223QM3T3TQ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schmiedek%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchmiedek%20F%2C%20Kroehne%20U%2C%20Goldhammer%20F%2C%20et%20al.%20General%20cognitive%20ability%20assessment%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%26%23x2013%3B%20The%20block-adaptive%20number%20series%20task.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A924-935.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011407%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011407%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22General%20cognitive%20ability%20assessment%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%5Cu2013%20The%20block-adaptive%20number%20series%20task%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Schmiedek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulf%22%2C%22lastName%22%3A%22Kroehne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Goldhammer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20J.%22%2C%22lastName%22%3A%22Prindle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulman%22%2C%22lastName%22%3A%22Lindenberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Zillich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Kleineidam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rujescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nako%22%2C%22lastName%22%3A%22Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2011407%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2011407%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A06%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22QT3LRTLF%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Streit%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStreit%20F%2C%20Zillich%20L%2C%20Frank%20J%2C%20et%20al.%20Lifetime%20and%20current%20depression%20in%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A865-880.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2014152%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2014152%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lifetime%20and%20current%20depression%20in%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Zillich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josef%22%2C%22lastName%22%3A%22Frank%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Kleineidam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%20T.%22%2C%22lastName%22%3A%22Baune%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Schmiedek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelika%22%2C%22lastName%22%3A%22Erhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NAKO%20Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22R%5Cu00fcbsamen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Perna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolph%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%5Cu00fchrer%22%2C%22lastName%22%3A%22Amand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Insa%22%2C%22lastName%22%3A%22Feinkohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2014152%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2014152%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A06%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22AF9K6IQZ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Huemer%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHuemer%20MT%2C%20Kluttig%20A%2C%20Fischer%20B%2C%20et%20al.%20Grip%20strength%20values%20and%20cut-off%20points%20based%20on%20over%20200%2C000%20adults%20of%20the%20German%20National%20Cohort%20-%20a%20comparison%20to%20the%20EWGSOP2%20cut-off%20points.%20%3Ci%3EAge%20and%20Ageing%3C%5C%2Fi%3E.%202023%3B52%281%29%3Aafac324.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fageing%5C%2Fafac324%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fageing%5C%2Fafac324%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Grip%20strength%20values%20and%20cut-off%20points%20based%20on%20over%20200%2C000%20adults%20of%20the%20German%20National%20Cohort%20-%20a%20comparison%20to%20the%20EWGSOP2%20cut-off%20points%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Theres%22%2C%22lastName%22%3A%22Huemer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Sch%5Cu00f6ttker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannah%22%2C%22lastName%22%3A%22Stocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Drey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Thorand%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20European%20Working%20Group%20on%20Sarcopenia%20in%20Older%20People%20%28EWGSOP%29%20updated%20in%202018%20the%20cut-off%20points%20for%20low%20grip%20strength%20to%20assess%20sarcopenia%20based%20on%20pooled%20data%20from%2012%20British%20studies.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objective%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Comparison%20of%20the%20EWGSOP2%20cut-off%20points%20for%20low%20grip%20strength%20to%20those%20derived%20from%20a%20large%20German%20sample.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20assessed%20the%20grip%20strength%20distribution%20across%20age%20and%20derived%20low%20grip%20strength%20cut-off%20points%20for%20men%20and%20women%20%28peak%20mean%20-2.5%5Cu2009%5Cu00d7%5Cu2009SD%29%20based%20on%20200%2C389%20German%20National%20Cohort%20%28NAKO%29%20participants%20aged%2019%5Cu201375%5Cu00a0years.%20In%201%2C012%20Cooperative%20Health%20Research%20in%20the%20Region%20of%20Augsburg%20%28KORA%29-Age%20participants%20aged%2065%5Cu201393%5Cu00a0years%2C%20we%20calculated%20the%20age-standardised%20prevalence%20of%20low%20grip%20strength%20and%20time-dependent%20sensitivity%20and%20specificity%20for%20all-cause%20mortality.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Grip%20strength%20increased%20in%20the%20third%20and%20fourth%20decade%20of%20life%20and%20declined%20afterwards.%20Calculated%20cut-off%20points%20for%20low%20grip%20strength%20were%2029%5Cu00a0kg%20for%20men%20and%2018%5Cu00a0kg%20for%20women.%20In%20KORA-Age%2C%20the%20age-standardised%20prevalence%20of%20low%20grip%20strength%20was%201.5%5Cu00d7%20higher%20for%20NAKO-derived%20%2817.7%25%29%20compared%20to%20EWGSOP2%20%2811.7%25%29%20cut-off%20points.%20NAKO-derived%20cut-off%20points%20yielded%20a%20higher%20sensitivity%20and%20lower%20specificity%20for%20all-cause%20mortality.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Cut-off%20points%20for%20low%20grip%20strength%20from%20German%20population-based%20data%20were%202%5Cu00a0kg%20higher%20than%20the%20EWGSOP2%20cut-off%20points.%20Higher%20cut-off%20points%20increase%20the%20sensitivity%2C%20thereby%20suggesting%20an%20intervention%20for%20more%20patients%20at%20risk%2C%20while%20other%20individuals%20might%20receive%20additional%20diagnostics%5C%2Ftreatment%20without%20the%20urgent%20need.%20Research%20on%20the%20effectiveness%20of%20intervention%20in%20patients%20with%20low%20grip%20strength%20defined%20by%20different%20cut-off%20points%20is%20needed.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Fageing%5C%2Fafac324%22%2C%22ISSN%22%3A%220002-0729%2C%201468-2834%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fageing%5C%2Farticle%5C%2Fdoi%5C%2F10.1093%5C%2Fageing%5C%2Fafac324%5C%2F6998045%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A25%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22AEEWLCZC%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ortmann%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EOrtmann%20J%2C%20Heise%20JK%2C%20Janzen%20I%2C%20et%20al.%20Suitability%20and%20user%20acceptance%20of%20the%20eResearch%20system%20%26%23x201C%3BProspective%20Monitoring%20and%20Management%20App%20%28PIA%29%26%23x201D%3B%26%23x2014%3BThe%20example%20of%20an%20epidemiological%20study%20on%20infectious%20diseases.%20Page%20K%2C%20ed.%20%3Ci%3EPLoS%20ONE%3C%5C%2Fi%3E.%202023%3B18%281%29%3Ae0279969.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0279969%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0279969%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Suitability%20and%20user%20acceptance%20of%20the%20eResearch%20system%20%5Cu201cProspective%20Monitoring%20and%20Management%20App%20%28PIA%29%5Cu201d%5Cu2014The%20example%20of%20an%20epidemiological%20study%20on%20infectious%20diseases%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Ortmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kristin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Janzen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Jenniches%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Fr%5Cu00f6mke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Kimberly%22%2C%22lastName%22%3A%22Page%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20eResearch%20system%20%5Cu201cProspective%20Monitoring%20and%20Management%20App%20%28PIA%29%5Cu201d%20allows%20researchers%20to%20implement%20questionnaires%20on%20any%20topic%20and%20to%20manage%20biosamples.%20Currently%2C%20we%20use%20PIA%20in%20the%20longitudinal%20study%20ZIFCO%20%28Integrated%20DZIF%20Infection%20Cohort%20within%20the%20German%20National%20Cohort%29%20in%20Hannover%20%28Germany%29%20to%20investigate%20e.g.%20associations%20of%20risk%20factors%20and%20infectious%20diseases.%20Our%20aim%20was%20to%20assess%20user%20acceptance%20and%20compliance%20to%20determine%20suitability%20of%20PIA%20for%20epidemiological%20research%20on%20transient%20infectious%20diseases.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20ZIFCO%20participants%20used%20PIA%20to%20answer%20weekly%20questionnaires%20on%20health%20status%20and%20report%20spontaneous%20onset%20of%20symptoms.%20In%20case%20of%20symptoms%20of%20a%20respiratory%20infection%2C%20the%20app%20requested%20participants%20to%20self-sample%20a%20nasal%20swab%20for%20viral%20analysis.%20To%20assess%20user%20acceptance%2C%20we%20implemented%20the%20System%20Usability%20Scale%20%28SUS%29%20and%20fitted%20a%20linear%20regression%20model%20on%20the%20resulting%20score.%20For%20investigation%20of%20compliance%20with%20submitting%20the%20weekly%20health%20questionnaires%2C%20we%20used%20a%20logistic%20regression%20model%20with%20binomial%20response.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20analyzed%20data%20of%20313%20participants%20%28median%20age%2052.5%20years%2C%2052.4%25%20women%29.%20An%20average%20SUS%20of%2072.0%20reveals%20good%20acceptance%20of%20PIA.%20Participants%20with%20a%20higher%20technology%20readiness%20score%20at%20the%20beginning%20of%20study%20participation%20also%20reported%20higher%20user%20acceptance.%20Overall%20compliance%20with%20submitting%20the%20weekly%20health%20questionnaires%20showed%20a%20median%20of%2055.7%25.%20Being%20female%2C%20of%20younger%20age%20and%20being%20enrolled%20for%20a%20longer%20time%20decreased%20the%20odds%20to%20respond.%20However%2C%20women%20over%2060%20had%20a%20higher%20chance%20to%20respond%20than%20women%20under%2060%2C%20while%20men%20under%2040%20had%20the%20highest%20chance%20to%20respond.%20Compliance%20with%20nasal%20swab%20self-sampling%20was%2077.2%25.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20findings%20show%20that%20PIA%20is%20suitable%20for%20the%20use%20in%20epidemiologic%20studies%20with%20regular%20short%20questionnaires.%20Still%2C%20we%20will%20focus%20on%20user%20engagement%20and%20gamification%20for%20the%20further%20development%20of%20PIA%20to%20help%20incentivize%20regular%20and%20long-term%20participation.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0279969%22%2C%22ISSN%22%3A%221932-6203%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0279969%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A24%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22J4LJUBZH%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Merz%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMerz%20S%2C%20Jaehn%20P%2C%20Pischon%20T%2C%20et%20al.%20Investigating%20people%26%23x2019%3Bs%20attitudes%20towards%20participating%20in%20longitudinal%20health%20research%3A%20an%20intersectionality-informed%20perspective.%20%3Ci%3EInt%20J%20Equity%20Health%3C%5C%2Fi%3E.%202023%3B22%281%29%3A23.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12939-022-01807-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12939-022-01807-0%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Investigating%20people%5Cu2019s%20attitudes%20towards%20participating%20in%20longitudinal%20health%20research%3A%20an%20intersectionality-informed%20perspective%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sibille%22%2C%22lastName%22%3A%22Merz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Jaehn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Guenther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Holmberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22the%20AdvanceGender%20Study%20Group%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriele%22%2C%22lastName%22%3A%22Bolte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%22%2C%22lastName%22%3A%22Mena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Rommel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anke-Christine%22%2C%22lastName%22%3A%22Sa%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathleen%22%2C%22lastName%22%3A%22P%5Cu00f6ge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Strasser%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Increasing%20evidence%20suggests%20that%20participation%20proportions%20in%20longitudinal%20health%20research%20vary%20according%20to%20sex%5C%2Fgender%2C%20age%2C%20social%20class%2C%20or%20migration%20status.%20Intersectionality%20scholarship%20purports%20that%20such%20social%20categories%20cannot%20be%20understood%20in%20isolation%20and%20makes%20visible%20the%20co-dependent%20nature%20of%20the%20social%20determinants%20of%20health%20and%20illness.%20This%20paper%20uses%20an%20intersectionality-informed%20approach%20in%20order%20to%20expand%20the%20understanding%20of%20why%20people%20participate%20in%20health%20research%2C%20and%20the%20impact%20of%20intersecting%20social%20structures%20and%20experiences%20on%20these%20attitudes.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20sample%20of%2080%20respondents%20who%20had%20previously%20either%20accepted%20or%20declined%20an%20invitation%20to%20participate%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20participated%20in%20our%20interview%20study.%20Interviews%20were%20semi-structured%20and%20contained%20both%20narrative%20elements%20and%20more%20structured%20probes.%20Data%20analysis%20proceeded%20in%20two%20steps%3A%20first%2C%20the%20entire%20data%20set%20was%20analysed%20thematically%20%28separately%20for%20participants%20and%20non-participants%29%3B%20second%2C%20key%20themes%20were%20compared%20across%20self-reported%20sex%5C%2Fgender%2C%20age%20group%20and%20migration%20status%20to%20identify%20differences%20and%20commonalities.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Respondents%5Cu2019%20attitudes%20towards%20study%20participation%20can%20be%20categorised%20into%20four%20themes%3A%20wanting%20to%20make%20a%20contribution%2C%20seeking%20personalised%20health%20information%2C%20excitement%20and%20feeling%20chosen%2C%20and%20seeking%20social%20recognition.%20Besides%20citing%20logistical%20challenges%2C%20non-participants%20narrated%20adverse%20experiences%20with%20or%20attitudes%20towards%20science%20and%20the%20healthcare%20system%20that%20deterred%20them%20from%20participating.%20A%20range%20of%20social%20experiences%20and%20cultural%20value%20systems%20shaped%20such%20attitudes%3B%20in%20particular%2C%20this%20includes%20the%20cultural%20authority%20of%20science%20as%20an%20arbiter%20of%20social%20questions%2C%20transgressing%20social%20categories%20and%20experiences%20of%20marginalisation.%20Care%20responsibilities%2C%20predominantly%20borne%20by%20female%20respondents%2C%20also%20impacted%20upon%20the%20decision%20to%20take%20part%20in%20NAKO.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20findings%20suggest%20that%20for%20participants%2C%20health%20research%20constitutes%20a%20site%20of%20distinction%20in%20the%20sense%20of%20making%20a%20difference%20and%20being%20distinct%20or%20distinguishable%2C%20whereas%20non-participants%20inhabited%20an%20orientation%20towards%20science%20that%20reflected%20their%20subjective%20marginalisation%20through%20science.%20No%20clear%20relationship%20can%20thereby%20be%20presumed%20between%20social%20location%20and%20a%20particular%20attitude%20towards%20study%20participation%3B%20rather%2C%20such%20attitudes%20transgress%20and%20challenge%20categorical%20boundaries.%20This%20challenges%20the%20understanding%20of%20particular%20populations%20as%20more%20or%20less%20disadvantaged%2C%20or%20as%20more%20or%20less%20inclined%20to%20participate%20in%20health%20research.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12939-022-01807-0%22%2C%22ISSN%22%3A%221475-9276%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fequityhealthj.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12939-022-01807-0%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A23%3A58Z%22%7D%7D%2C%7B%22key%22%3A%229BXUK9AK%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gatidis%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EGatidis%20S%2C%20Kart%20T%2C%20Fischer%20M%2C%20et%20al.%20Better%20Together%3A%20Data%20Harmonization%20and%20Cross-Study%20Analysis%20of%20Abdominal%20MRI%20Data%20From%20UK%20Biobank%20and%20the%20German%20National%20Cohort.%20%3Ci%3EInvest%20Radiol%3C%5C%2Fi%3E.%202023%3B58%285%29%3A346-354.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000941%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000941%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Better%20Together%3A%20Data%20Harmonization%20and%20Cross-Study%20Analysis%20of%20Abdominal%20MRI%20Data%20From%20UK%20Biobank%20and%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Turkay%22%2C%22lastName%22%3A%22Kart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Winzeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Glocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenjia%22%2C%22lastName%22%3A%22Bai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Friedrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Mayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%20M.%22%2C%22lastName%22%3A%22Schaarschmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lale%22%2C%22lastName%22%3A%22Umutle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%22%2C%22lastName%22%3A%22Sch%5Cu00f6lkopf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rueckert%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20UK%20Biobank%20%28UKBB%29%20and%20German%20National%20Cohort%20%28NAKO%29%20are%20among%20the%20largest%20cohort%20studies%2C%20capturing%20a%20wide%20range%20of%20health-related%20data%20from%20the%20general%20population%2C%20including%20comprehensive%20magnetic%20resonance%20imaging%20%28MRI%29%20examinations.%20The%20purpose%20of%20this%20study%20was%20to%20demonstrate%20how%20MRI%20data%20from%20these%20large-scale%20studies%20can%20be%20jointly%20analyzed%20and%20to%20derive%20comprehensive%20quantitative%20image-based%20phenotypes%20across%20the%20general%20adult%20population.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Image-derived%20features%20of%20abdominal%20organs%20%28volumes%20of%20liver%2C%20spleen%2C%20kidneys%2C%20and%20pancreas%3B%20volumes%20of%20kidney%20hilum%20adipose%20tissue%3B%20and%20fat%20fractions%20of%20liver%20and%20pancreas%29%20were%20extracted%20from%20T1-weighted%20Dixon%20MRI%20data%20of%2017%2C996%20participants%20of%20UKBB%20and%20NAKO%20based%20on%20quality-controlled%20deep%20learning%20generated%20organ%20segmentations.%20To%20enable%20valid%20cross-study%20analysis%2C%20we%20first%20analyzed%20the%20data%20generating%20process%20using%20methods%20of%20causal%20discovery.%20We%20subsequently%20harmonized%20data%20from%20UKBB%20and%20NAKO%20using%20the%20ComBat%20approach%20for%20batch%20effect%20correction.%20We%20finally%20performed%20quantile%20regression%20on%20harmonized%20data%20across%20studies%20providing%20quantitative%20models%20for%20the%20variation%20of%20image-derived%20features%20stratified%20for%20sex%20and%20dependent%20on%20age%2C%20height%2C%20and%20weight.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20from%208791%20UKBB%20participants%20%2849.9%25%20female%3B%20age%2C%2063%20%5Cu00b1%207.5%20years%29%20and%209205%20NAKO%20participants%20%2849.1%25%20female%2C%20age%3A%2051.8%20%5Cu00b1%2011.4%20years%29%20were%20analyzed.%20Analysis%20of%20the%20data%20generating%20process%20revealed%20direct%20effects%20of%20age%2C%20sex%2C%20height%2C%20weight%2C%20and%20the%20data%20source%20%28UKBB%20vs%20NAKO%29%20on%20image-derived%20features.%20Correction%20of%20data%20source-related%20effects%20resulted%20in%20markedly%20improved%20alignment%20of%20image-derived%20features%20between%20UKBB%20and%20NAKO.%20Cross-study%20analysis%20on%20harmonized%20data%20revealed%20comprehensive%20quantitative%20models%20for%20the%20phenotypic%20variation%20of%20abdominal%20organs%20across%20the%20general%20adult%20population.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Cross-study%20analysis%20of%20MRI%20data%20from%20UKBB%20and%20NAKO%20as%20proposed%20in%20this%20work%20can%20be%20helpful%20for%20future%20joint%20data%20analyses%20across%20cohorts%20linking%20genetic%2C%20environmental%2C%20and%20behavioral%20risk%20factors%20to%20MRI-derived%20phenotypes%20and%20provide%20reference%20values%20for%20clinical%20diagnostics.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FRLI.0000000000000941%22%2C%22ISSN%22%3A%221536-0210%2C%200020-9996%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2F10.1097%5C%2FRLI.0000000000000941%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A22%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22JJMBVVJE%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Haueise%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHaueise%20T%2C%20Schick%20F%2C%20Stefan%20N%2C%20et%20al.%20Analysis%20of%20volume%20and%20topography%20of%20adipose%20tissue%20in%20the%20trunk%3A%20Results%20of%20MRI%20of%2011%2C141%20participants%20in%20the%20German%20National%20Cohort.%20%3Ci%3ESci%20Adv%3C%5C%2Fi%3E.%202023%3B9%2819%29%3Aeadd0433.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.add0433%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.add0433%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Analysis%20of%20volume%20and%20topography%20of%20adipose%20tissue%20in%20the%20trunk%3A%20Results%20of%20MRI%20of%2011%2C141%20participants%20in%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Haueise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fritz%22%2C%22lastName%22%3A%22Schick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Stefan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%20B.%22%2C%22lastName%22%3A%22Weiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Nattenm%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22G%5Cu00f6bel-Gu%5Cu00e9niot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Norajitra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Nonnenmacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%20H.%22%2C%22lastName%22%3A%22Maier-Hein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lale%22%2C%22lastName%22%3A%22Umutlu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Rospleszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Hosten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juergen%22%2C%22lastName%22%3A%22Machann%22%7D%5D%2C%22abstractNote%22%3A%22This%20research%20addresses%20the%20assessment%20of%20adipose%20tissue%20%28AT%29%20and%20spatial%20distribution%20of%20visceral%20%28VAT%29%20and%20subcutaneous%20fat%20%28SAT%29%20in%20the%20trunk%20from%20standardized%20magnetic%20resonance%20imaging%20at%203%20T%2C%20thereby%20demonstrating%20the%20feasibility%20of%20deep%20learning%20%28DL%29%5Cu2013based%20image%20segmentation%20in%20a%20large%20population-based%20cohort%20in%20Germany%20%28five%20sites%29.%20Volume%20and%20distribution%20of%20AT%20play%20an%20essential%20role%20in%20the%20pathogenesis%20of%20insulin%20resistance%2C%20a%20risk%20factor%20of%20developing%20metabolic%5C%2Fcardiovascular%20diseases.%20Cross-validated%20training%20of%20the%20DL-segmentation%20model%20led%20to%20a%20mean%20Dice%20similarity%20coefficient%20of%20%3E0.94%2C%20corresponding%20to%20a%20mean%20absolute%20volume%20deviation%20of%20about%2022%20ml.%20SAT%20is%20significantly%20increased%20in%20women%20compared%20to%20men%2C%20whereas%20VAT%20is%20increased%20in%20males.%20Spatial%20distribution%20shows%20age-%20and%20body%20mass%20index%5Cu2013related%20displacements.%20DL-based%20image%20segmentation%20provides%20robust%20and%20fast%20quantification%20of%20AT%20%28%5Cu224815%20s%20per%20dataset%20versus%203%20to%204%20hours%20for%20manual%20processing%29%20and%20assessment%20of%20its%20spatial%20distribution%20from%20magnetic%20resonance%20images%20in%20large%20cohort%20studies.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Automated%20analysis%20of%20body%20fat%20at%20population%20level%20provides%20insight%20into%20anthropometric%20associations%20with%20metabolic%20risk.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fsciadv.add0433%22%2C%22ISSN%22%3A%222375-2548%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fsciadv.add0433%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A21%3A35Z%22%7D%7D%2C%7B%22key%22%3A%223AUYMB29%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Streit%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStreit%20F%2C%20V%26%23xF6%3Blker%20MP%2C%20Klinger-K%26%23xF6%3Bnig%20J%2C%20et%20al.%20The%20interplay%20of%20family%20history%20of%20depression%20and%20early%20trauma%3A%20associations%20with%20lifetime%20and%20current%20depression%20in%20the%20German%20national%20cohort%20%28NAKO%29.%20%3Ci%3EFront%20Epidemiol%3C%5C%2Fi%3E.%202023%3B3%3A1099235.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffepid.2023.1099235%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffepid.2023.1099235%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20interplay%20of%20family%20history%20of%20depression%20and%20early%20trauma%3A%20associations%20with%20lifetime%20and%20current%20depression%20in%20the%20German%20national%20cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maja%20P.%22%2C%22lastName%22%3A%22V%5Cu00f6lker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Zillich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Josef%22%2C%22lastName%22%3A%22Frank%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Reinhard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%20C.%22%2C%22lastName%22%3A%22Foo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%20H.%22%2C%22lastName%22%3A%22Witt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%22%2C%22lastName%22%3A%22Sirignano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Riedel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Do%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20J.%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Stahl-Pehe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Perna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Konzok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Family%20history%20of%20depression%20and%20childhood%20maltreatment%20are%20established%20risk%20factors%20for%20depression.%20However%2C%20how%20these%20factors%20are%20interrelated%20and%20jointly%20influence%20depression%20risk%20is%20not%20well%20understood.%20The%20present%20study%20investigated%20%28i%29%20if%20childhood%20maltreatment%20is%20associated%20with%20a%20family%20history%20of%20depression%20%28ii%29%20if%20family%20history%20and%20childhood%20maltreatment%20are%20associated%20with%20increased%20lifetime%20and%20current%20depression%2C%20and%20whether%20both%20factors%20interact%20beyond%20their%20main%20effects%2C%20and%20%28iii%29%20if%20family%20history%20affects%20lifetime%20and%20current%20depression%20via%20childhood%20maltreatment.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Analyses%20were%20based%20on%20a%20subgroup%20of%20the%20first%20100%2C000%20participants%20of%20the%20German%20National%20Cohort%20%28NAKO%29%2C%20with%20complete%20information%20%2858%2C703%20participants%2C%20mean%20age%5Cu2009%3D%5Cu200951.2%20years%2C%2053%25%20female%29.%20Parental%20family%20history%20of%20depression%20was%20assessed%20via%20self-report%2C%20childhood%20maltreatment%20with%20the%20Childhood%20Trauma%20Screener%20%28CTS%29%2C%20lifetime%20depression%20with%20self-reported%20physician%27s%20diagnosis%20and%20the%20Mini-International%20Neuropsychiatric%20Interview%20%28MINI%29%2C%20and%20current%20depressive%20symptoms%20with%20the%20depression%20scale%20of%20the%20Patient%20Health%20Questionnaire%20%28PHQ-9%29.%20Generalized%20linear%20models%20were%20used%20to%20test%20main%20and%20interaction%20effects.%20Mediation%20was%20tested%20using%20causal%20mediation%20analyses.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Higher%20frequencies%20of%20the%20childhood%20maltreatment%20measures%20were%20found%20in%20subjects%20reporting%20a%20positive%20family%20history%20of%20depression.%20Family%20history%20and%20childhood%20maltreatment%20were%20independently%20associated%20with%20increased%20depression.%20No%20statistical%20interactions%20of%20family%20history%20and%20childhood%20maltreatment%20were%20found%20for%20the%20lifetime%20depression%20measures.%20For%20current%20depressive%20symptoms%20%28PHQ-9%20sum%20score%29%2C%20an%20interaction%20was%20found%2C%20with%20stronger%20associations%20of%20childhood%20maltreatment%20and%20depression%20in%20subjects%20with%20a%20positive%20family%20history.%20Childhood%20maltreatment%20was%20estimated%20to%20mediate%207%25%5Cu201312%25%20of%20the%20effect%20of%20family%20history%20on%20depression%2C%20with%20higher%20mediated%20proportions%20in%20subjects%20whose%20parents%20had%20a%20depression%20onset%20below%2040%20years.%20Abuse%20showed%20stronger%20associations%20with%20family%20history%20and%20depression%2C%20and%20higher%20mediated%20proportions%20of%20family%20history%20effects%20on%20depression%20than%20neglect.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20present%20study%20confirms%20the%20association%20of%20childhood%20maltreatment%20and%20family%20history%20with%20depression%20in%20a%20large%20population-based%20cohort.%20While%20analyses%20provide%20little%20evidence%20for%20the%20joint%20effects%20of%20both%20risk%20factors%20on%20depression%20beyond%20their%20individual%20effects%2C%20results%20are%20consistent%20with%20family%20history%20affecting%20depression%20via%20childhood%20maltreatment%20to%20a%20small%20extent.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffepid.2023.1099235%22%2C%22ISSN%22%3A%222674-1199%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffepid.2023.1099235%5C%2Ffull%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A20%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22MNI5R4W6%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ewendt%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EEwendt%20F%2C%20Schmitt%20M%2C%20Kluttig%20A%2C%20et%20al.%20Association%20between%20vitamin%20D%20status%20and%20eryptosis%26%23x2013%3Bresults%20from%20the%20German%20National%20Cohort%20Study.%20%3Ci%3EAnn%20Hematol%3C%5C%2Fi%3E.%202023%3B102%286%29%3A1351-1361.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00277-023-05239-w%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00277-023-05239-w%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20between%20vitamin%20D%20status%20and%20eryptosis%5Cu2013results%20from%20the%20German%20National%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franz%22%2C%22lastName%22%3A%22Ewendt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Schmitt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22K%5Cu00fchn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Hirche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20B.%22%2C%22lastName%22%3A%22Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Ludwig-Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%22%2C%22lastName%22%3A%22W%5Cu00e4tjen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul-Christian%22%2C%22lastName%22%3A%22B%5Cu00fcrkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22F%5Cu00f6ller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriele%20I.%22%2C%22lastName%22%3A%22Stangl%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Vitamin%20D%2C%20besides%20its%20classical%20effect%20on%20mineral%20homeostasis%20and%20bone%20remodeling%2C%20can%20also%20modulate%20apoptosis.%20A%20special%20form%20of%20apoptosis%20termed%20eryptosis%20appears%20in%20erythrocytes.%20Eryptosis%20is%20characterized%20by%20cell%20shrinkage%2C%20membrane%20blebbing%2C%20and%20cell%20membrane%20phospholipid%20disorganization%20and%20associated%20with%20diseases%20such%20as%20sepsis%2C%20malaria%20or%20iron%20deficiency%2C%20and%20impaired%20microcirculation.%20To%20our%20knowledge%2C%20this%20is%20the%20first%20study%20that%20linked%20vitamin%20D%20with%20eryptosis%20in%20humans.%20This%20exploratory%20cross-sectional%20trial%20investigated%20the%20association%20between%20the%20vitamin%20D%20status%20assessed%20by%20the%20concentration%20of%20plasma%2025-hydroxyvitamin%20D%20%2825%28OH%29D%29%20and%20eryptosis.%20Plasma%2025%28OH%29D%20was%20analyzed%20by%20LC%5Cu2013MS%5C%2FMS%2C%20and%20eryptosis%20was%20estimated%20from%20annexin%20V-FITC-binding%20erythrocytes%20by%20FACS%20analysis%20in%202074%20blood%20samples%20from%20participants%20of%20the%20German%20National%20Cohort%20Study.%20We%20observed%20a%20weak%20but%20clear%20correlation%20between%20low%20vitamin%20D%20status%20and%20increased%20eryptosis%20%28%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20r%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu2009%5Cu2009%5Cu2212%5Cu20090.15%3B%2095%25%20CI%20%5B%5Cu2212%5Cu20090.19%2C%5Cu2009%5Cu2212%5Cu20090.10%5D%29.%20There%20were%20no%20differences%20in%20plasma%20concentrations%20of%2025%28OH%29D%20and%20eryptosis%20between%20male%20and%20female%20subjects.%20This%20finding%20raises%20questions%20of%20the%20importance%20of%20vitamin%20D%20status%20for%20eryptosis%20in%20terms%20of%20increased%20risk%20for%20anemia%20or%20cardiovascular%20events.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00277-023-05239-w%22%2C%22ISSN%22%3A%220939-5555%2C%201432-0584%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00277-023-05239-w%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A20%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22RZCX77KR%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Vonneilich%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EVonneilich%20N%2C%20Becher%20H%2C%20Bohn%20B%2C%20et%20al.%20Associations%20of%20Migration%2C%20Socioeconomic%20Position%20and%20Social%20Relations%20With%20Depressive%20Symptoms%20%26%23x2013%3B%20Analyses%20of%20the%20German%20National%20Cohort%20Baseline%20Data.%20%3Ci%3EInt%20J%20Public%20Health%3C%5C%2Fi%3E.%202023%3B68%3A1606097.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2023.1606097%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Fijph.2023.1606097%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20of%20Migration%2C%20Socioeconomic%20Position%20and%20Social%20Relations%20With%20Depressive%20Symptoms%20%5Cu2013%20Analyses%20of%20the%20German%20National%20Cohort%20Baseline%20Data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Vonneilich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carolina%22%2C%22lastName%22%3A%22Klett-Tammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Velasquez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dmitry%22%2C%22lastName%22%3A%22Sergeev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wiessner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22L%5Cu00fcdecke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Von%20Dem%20Knesebeck%22%7D%5D%2C%22abstractNote%22%3A%22Objectives%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20analyze%20whether%20the%20prevalence%20of%20depressive%20symptoms%20differs%20among%20various%20migrant%20and%20non-migrant%20populations%20in%20Germany%20and%20to%20what%20extent%20these%20differences%20can%20be%20attributed%20to%20socioeconomic%20position%20%28SEP%29%20and%20social%20relations.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20health%20study%20%28NAKO%29%20is%20a%20prospective%20multicenter%20cohort%20study%20%28N%20%3D%20204%2C878%29.%20Migration%20background%20%28assessed%20based%20on%20citizenship%20and%20country%20of%20birth%20of%20both%20participant%20and%20parents%29%20was%20used%20as%20independent%20variable%2C%20age%2C%20sex%2C%20Social%20Network%20Index%2C%20the%20availability%20of%20emotional%20support%2C%20SEP%20%28relative%20income%20position%20and%20educational%20status%29%20and%20employment%20status%20were%20introduced%20as%20covariates%20and%20depressive%20symptoms%20%28PHQ-9%29%20as%20dependent%20variable%20in%20logistic%20regression%20models.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Increased%20odds%20ratios%20of%20depressive%20symptoms%20were%20found%20in%20all%20migrant%20subgroups%20compared%20to%20non-migrants%20and%20varied%20regarding%20regions%20of%20origins.%20Elevated%20odds%20ratios%20decreased%20when%20SEP%20and%20social%20relations%20were%20included.%20Attenuations%20varied%20across%20migrant%20subgroups.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20gap%20in%20depressive%20symptoms%20can%20partly%20be%20attributed%20to%20SEP%20and%20social%20relations%2C%20with%20variations%20between%20migrant%20subgroups.%20The%20integration%20paradox%20is%20likely%20to%20contribute%20to%20the%20explanation%20of%20the%20results.%20Future%20studies%20need%20to%20consider%20heterogeneity%20among%20migrant%20subgroups%20whenever%20possible.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Fijph.2023.1606097%22%2C%22ISSN%22%3A%221661-8564%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ssph-journal.org%5C%2Farticles%5C%2F10.3389%5C%2Fijph.2023.1606097%5C%2Ffull%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A18%3A56Z%22%7D%7D%2C%7B%22key%22%3A%226PEPW7BB%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fischer%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFischer%20M%2C%20K%26%23xFC%3Bstner%20T%2C%20Pappa%20S%2C%20et%20al.%20Identification%20of%20radiomic%20biomarkers%20in%20a%20set%20of%20four%20skeletal%20muscle%20groups%20on%20Dixon%20MRI%20of%20the%20NAKO%20MR%20study.%20%3Ci%3EBMC%20Med%20Imaging%3C%5C%2Fi%3E.%202023%3B23%281%29%3A104.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12880-023-01056-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12880-023-01056-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Identification%20of%20radiomic%20biomarkers%20in%20a%20set%20of%20four%20skeletal%20muscle%20groups%20on%20Dixon%20MRI%20of%20the%20NAKO%20MR%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sofia%22%2C%22lastName%22%3A%22Pappa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Bette%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Schramm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Haubold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Nensa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Nonnenmacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktoria%22%2C%22lastName%22%3A%22Palm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Kiefer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fritz%22%2C%22lastName%22%3A%22Schick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20In%20this%20work%2C%20we%20propose%20a%20processing%20pipeline%20for%20the%20extraction%20and%20identification%20of%20meaningful%20radiomics%20biomarkers%20in%20skeletal%20muscle%20tissue%20as%20displayed%20using%20Dixon-weighted%20MRI.%20Diverse%20and%20robust%20radiomics%20features%20can%20be%20identified%20that%20may%20be%20of%20aid%20in%20the%20accurate%20quantification%20e.g.%20varying%20degrees%20of%20sarcopenia%20in%20respective%20muscles%20of%20large%20cohorts.%20As%20such%2C%20the%20approach%20comprises%20the%20texture%20feature%20extraction%20from%20raw%20data%20based%20on%20well%20established%20approaches%2C%20such%20as%20a%20nnU-Net%20neural%20network%20and%20the%20Pyradiomics%20toolbox%2C%20a%20subsequent%20selection%20according%20to%20adequate%20conditions%20for%20the%20muscle%20tissue%20of%20the%20general%20population%2C%20and%20an%20importance-based%20ranking%20to%20further%20narrow%20the%20amount%20of%20meaningful%20features%20with%20respect%20to%20auxiliary%20targets.%20The%20performance%20was%20investigated%20with%20respect%20to%20the%20included%20auxiliary%20targets%2C%20namely%20age%2C%20body%20mass%20index%20%28BMI%29%2C%20and%20fat%20fraction%20%28FF%29.%20Four%20skeletal%20muscles%20with%20different%20fiber%20architecture%20were%20included%3A%20the%20mm.%20glutaei%2C%20m.%20psoas%2C%20as%20well%20as%20the%20extensors%20and%20adductors%20of%20the%20thigh.%20The%20selection%20allowed%20for%20a%20reduction%20from%201015%20available%20texture%20features%20to%2065%20for%20age%2C%2053%20for%20BMI%2C%20and%2036%20for%20FF%20from%20the%20available%20fat%5C%2Fwater%20contrast%20images%20considering%20all%20muscles%20jointly.%20Further%2C%20the%20dependence%20of%20the%20importance%20rankings%20calculated%20for%20the%20auxiliary%20targets%20on%20validation%20sets%20%28in%20a%20cross-validation%20scheme%29%20was%20investigated%20by%20boxplots.%20In%20addition%2C%20significant%20differences%20between%20subgroups%20of%20respective%20auxiliary%20targets%20as%20well%20as%20between%20both%20sexes%20were%20shown%20to%20be%20present%20within%20the%20ten%20lowest%20ranked%20features%20by%20means%20of%20Kruskal-Wallis%20H-tests%20and%20Mann-Whitney%20U-tests.%20The%20prediction%20performance%20for%20the%20selected%20features%20and%20the%20ranking%20scheme%20were%20verified%20on%20validation%20sets%20by%20a%20random%20forest%20based%20multi-class%20classification%2C%20with%20strong%20area%20under%20the%20curve%20%28AUC%29%20values%20of%20the%20receiver%20operator%20characteristic%20%28ROC%29%20of%2073.03%20%5Cu00b1%200.70%20%25%20and%2073.63%20%5Cu00b1%200.70%20%25%20for%20the%20water%20and%20fat%20images%20in%20age%2C%2080.68%20%5Cu00b1%200.30%20%25%20and%2088.03%20%5Cu00b1%200.89%20%25%20in%20BMI%2C%20as%20well%20as%2098.36%20%5Cu00b1%200.03%20%25%20and%2098.52%20%5Cu00b1%200.09%20%25%20in%20FF.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12880-023-01056-9%22%2C%22ISSN%22%3A%221471-2342%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcmedimaging.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12880-023-01056-9%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A17%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22DB69VG3R%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Koschig%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKoschig%20M%2C%20Conrad%20I%2C%20Berger%20K%2C%20et%20al.%20The%20mediating%20role%20of%20personality%20traits%20in%20the%20association%20between%20childhood%20trauma%20and%20depressive%20symptoms%20in%20young%20adulthood.%20%3Ci%3EJournal%20of%20Affective%20Disorders%3C%5C%2Fi%3E.%202023%3B338%3A373-379.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.06.027%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jad.2023.06.027%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20mediating%20role%20of%20personality%20traits%20in%20the%20association%20between%20childhood%20trauma%20and%20depressive%20symptoms%20in%20young%20adulthood%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Koschig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ines%22%2C%22lastName%22%3A%22Conrad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%20T.%22%2C%22lastName%22%3A%22Baune%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Denis%22%2C%22lastName%22%3A%22Gerstorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Perna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jad.2023.06.027%22%2C%22ISSN%22%3A%2201650327%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0165032723007930%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A16%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22Z4RRJ2B6%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Erhardt%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EErhardt%20A%2C%20Gelbrich%20G%2C%20Klinger-K%26%23xF6%3Bnig%20J%2C%20et%20al.%20Generalised%20anxiety%20and%20panic%20symptoms%20in%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A881-896.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011409%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011409%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Generalised%20anxiety%20and%20panic%20symptoms%20in%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelika%22%2C%22lastName%22%3A%22Erhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00f6tz%22%2C%22lastName%22%3A%22Gelbrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Kleineidam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NAKO%20Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Schmiedek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Deckert%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2011409%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2011409%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A11%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22CSJLHRKM%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kleineidam%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKleineidam%20L%2C%20Stark%20M%2C%20Riedel-Heller%20SG%2C%20et%20al.%20The%20assessment%20of%20cognitive%20function%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%26%23x2013%3B%20Associations%20of%20demographics%20and%20psychiatric%20symptoms%20with%20cognitive%20test%20performance.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A909-923.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011408%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011408%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20assessment%20of%20cognitive%20function%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%5Cu2013%20Associations%20of%20demographics%20and%20psychiatric%20symptoms%20with%20cognitive%20test%20performance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Kleineidam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melina%22%2C%22lastName%22%3A%22Stark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%20G.%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Schmiedek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelika%22%2C%22lastName%22%3A%22Erhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00f6tz%22%2C%22lastName%22%3A%22Gelbrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NAKO%20Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wagner%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2011408%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2011408%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A05%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22LPI6I9U2%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Klinger-K%5Cu00f6nig%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKlinger-K%26%23xF6%3Bnig%20J%2C%20Streit%20F%2C%20Erhardt%20A%2C%20et%20al.%20The%20assessment%20of%20childhood%20maltreatment%20and%20its%20associations%20with%20affective%20symptoms%20in%20adulthood%3A%20Results%20of%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A897-908.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011406%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011406%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20assessment%20of%20childhood%20maltreatment%20and%20its%20associations%20with%20affective%20symptoms%20in%20adulthood%3A%20Results%20of%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Klinger-K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Streit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelika%22%2C%22lastName%22%3A%22Erhardt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luca%22%2C%22lastName%22%3A%22Kleineidam%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Schmiedek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NAKO%20Investigators%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%20J.%22%2C%22lastName%22%3A%22Grabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannah%22%2C%22lastName%22%3A%22Stocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirjam%22%2C%22lastName%22%3A%22Frank%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%20G.%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Insa%22%2C%22lastName%22%3A%22Feinkohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20J%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunthard%22%2C%22lastName%22%3A%22St%5Cu00fcbs%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2011406%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2011406%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A42%3A06Z%22%7D%7D%2C%7B%22key%22%3A%227L488SX2%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hassenstein%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHassenstein%20MJ%2C%20Pischon%20T%2C%20Karch%20A%2C%20et%20al.%20Seropositivity%20of%20Borrelia%20burgdorferi%20s.l.%20in%20Germany%26%23x2014%3Ban%20analysis%20across%20four%20German%20National%20Cohort%20%28NAKO%29%20study%20sites.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202023%3B13%281%29%3A21087.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-47766-6%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-47766-6%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Seropositivity%20of%20Borrelia%20burgdorferi%20s.l.%20in%20Germany%5Cu2014an%20analysis%20across%20four%20German%20National%20Cohort%20%28NAKO%29%20study%20sites%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20J.%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Kerrinnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Janke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Lyme%20borreliosis%20%28LB%29%20is%20caused%20by%20the%20transmission%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Borrelia%20burgdorferi%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20s.l.%20from%20ticks%20to%20humans.%20Climate%20affects%20tick%20abundance%2C%20and%20climate%20change%20is%20projected%20to%20promote%20shifts%20in%20abundance%20in%20Europe%2C%20potentially%20increasing%20human%20exposure.%20We%20analyzed%20serum%20samples%20collected%20between%20the%20years%202014%5Cu20132019%20from%20German%20National%20Cohort%20%28NAKO%29%20participants%20at%20four%20study%20sites%20%28Augsburg%2C%20Berlin%2C%20Hanover%2C%20M%5Cu00fcnster%29%20for%20immunoglobulin%20G%20%28IgG%29%20and%20immunoglobulin%20M%20%28IgM%29%20antibodies%20using%20an%20enzyme%5Cu2010linked%20immunosorbent%20assay%20%28ELISA%29%20and%20line%20blot%20immunoassay%20as%20confirmatory%20test%20for%20positive%20and%20equivocal%20ELISA%20samples.%20We%20reported%20crude%20and%20weighted%20seropositivity%20proportions%20for%20local%20estimates.%20We%20used%20mixed%20model%20analysis%20to%20investigate%20associated%20factors%2C%20such%20as%20age%2C%20sex%2C%20migration%20background%2C%20or%20animal%20contacts.%20We%20determined%20the%20serostatus%20of%2014%2C207%20participants.%20The%20weighted%20seropositivity%20proportions%20were%203.4%25%20%28IgG%29%20and%200.4%25%20%28IgM%29%20in%20Augsburg%2C%204.1%25%20%28IgG%29%20and%200.6%25%20%28IgM%29%20in%20northern%20Berlin%2C%203.0%25%20%28IgG%29%20and%200.9%25%20%28IgM%29%20in%20Hanover%2C%20and%202.7%25%20%28IgG%29%20and%200.6%25%20%28IgM%29%20in%20M%5Cu00fcnster.%20We%20found%20higher%20odds%20for%20IgG%20seropositivity%20with%20advancing%20age%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20p%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3C%5Cu20090.001%29%2C%20among%20males%20compared%20to%20females%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20p%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3C%5Cu20090.001%29%20and%20reduced%20odds%20among%20participants%20with%20migration%20background%20compared%20to%20those%20without%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20p%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2009%3D%5Cu20090.001%29.%20We%20did%20not%20find%20evidence%20for%20an%20association%20between%20serostatus%20and%20depression%2C%20children%20within%20the%20household%2C%20or%20animal%20contact%2C%20respectively.%20We%20found%20low%20seropositivity%20proportions%20and%20indications%20of%20differences%20across%20the%20study%20locations%2C%20although%20between-group%20comparisons%20did%20not%20yield%20significant%20results.%20Comparisons%20to%20earlier%20research%20are%20subject%20to%20important%20limitations%3B%20however%2C%20our%20results%20indicate%20no%20major%20increases%20in%20seropositivity%20over%20time.%20Nevertheless%2C%20monitoring%20of%20seropositivity%20remains%20critical%20in%20light%20of%20potential%20climate-related%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Borrelia%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20exposure.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-47766-6%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-023-47766-6%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A41%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22VXTNXLFX%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schuppert%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchuppert%20C%2C%20Rospleszcz%20S%2C%20Hirsch%20JG%2C%20et%20al.%20Automated%20image%20quality%20assessment%20for%20selecting%20among%20multiple%20magnetic%20resonance%20image%20acquisitions%20in%20the%20German%20National%20Cohort%20study.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202023%3B13%281%29%3A22745.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-49569-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-49569-1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Automated%20image%20quality%20assessment%20for%20selecting%20among%20multiple%20magnetic%20resonance%20image%20acquisitions%20in%20the%20German%20National%20Cohort%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Schuppert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Rospleszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochen%20G.%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20C.%22%2C%22lastName%22%3A%22Hoinkiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22K%5Cu00f6hn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ricarda%22%2C%22lastName%22%3A%22Von%20Kr%5Cu00fcchten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maximilian%20F.%22%2C%22lastName%22%3A%22Russe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20J.%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanette%22%2C%22lastName%22%3A%22Schulz-Menger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Forsting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Hosten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxim%22%2C%22lastName%22%3A%22Zaitsev%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20In%20magnetic%20resonance%20imaging%20%28MRI%29%2C%20the%20perception%20of%20substandard%20image%20quality%20may%20prompt%20repetition%20of%20the%20respective%20image%20acquisition%20protocol.%20Subsequently%20selecting%20the%20preferred%20high-quality%20image%20data%20from%20a%20series%20of%20acquisitions%20can%20be%20challenging.%20An%20automated%20workflow%20may%20facilitate%20and%20improve%20this%20selection.%20We%20therefore%20aimed%20to%20investigate%20the%20applicability%20of%20an%20automated%20image%20quality%20assessment%20for%20the%20prediction%20of%20the%20subjectively%20preferred%20image%20acquisition.%20Our%20analysis%20included%20data%20from%2011%2C347%20participants%20with%20whole-body%20MRI%20examinations%20performed%20as%20part%20of%20the%20ongoing%20prospective%20multi-center%20German%20National%20Cohort%20%28NAKO%29%20study.%20Trained%20radiologic%20technologists%20repeated%20any%20of%20the%20twelve%20examination%20protocols%20due%20to%20induced%20setup%20errors%20and%5C%2For%20subjectively%20unsatisfactory%20image%20quality%20and%20chose%20a%20preferred%20acquisition%20from%20the%20resultant%20series.%20Up%20to%2011%20quantitative%20image%20quality%20parameters%20were%20automatically%20derived%20from%20all%20acquisitions.%20Regularized%20regression%20and%20standard%20estimates%20of%20diagnostic%20accuracy%20were%20calculated.%20Controlling%20for%20setup%20variations%20in%202342%20series%20of%20two%20or%20more%20acquisitions%2C%20technologists%20preferred%20the%20repetition%20over%20the%20initial%20acquisition%20in%201116%20of%201396%20series%20in%20which%20the%20initial%20setup%20was%20retained%20%2879.9%25%2C%20range%20across%20protocols%3A%2073%5Cu2013100%25%29.%20Image%20quality%20parameters%20then%20commonly%20showed%20statistically%20significant%20differences%20between%20chosen%20and%20discarded%20acquisitions.%20In%20regularized%20regression%20across%20all%20protocols%2C%20%5Cu2018structured%20noise%20maximum%5Cu2019%20was%20the%20strongest%20predictor%20for%20the%20technologists%5Cu2019%20choice%2C%20followed%20by%20%5Cu2018N%5C%2F2%20ghosting%20average%5Cu2019.%20Combinations%20of%20the%20automatically%20derived%20parameters%20provided%20an%20area%20under%20the%20ROC%20curve%20between%200.51%20and%200.74%20for%20the%20prediction%20of%20the%20technologists%5Cu2019%20choice.%20It%20is%20concluded%20that%20automated%20image%20quality%20assessment%20can%2C%20despite%20considerable%20performance%20differences%20between%20protocols%20and%20anatomical%20regions%2C%20contribute%20substantially%20to%20identifying%20the%20subjective%20preference%20in%20a%20series%20of%20MRI%20acquisitions%20and%20thus%20provide%20effective%20decision%20support%20to%20readers.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-49569-1%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-023-49569-1%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A40%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22QGSFKCYX%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bosquillon%20De%20Jarcy%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBosquillon%20De%20Jarcy%20L%2C%20Akbil%20B%2C%20Mhlekude%20B%2C%20et%20al.%2090K%5C%2FLGALS3BP%20expression%20is%20upregulated%20in%20COVID-19%20but%20may%20not%20restrict%20SARS-CoV-2%20infection.%20%3Ci%3EClin%20Exp%20Med%3C%5C%2Fi%3E.%202023%3B23%287%29%3A3689-3700.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10238-023-01077-2%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10238-023-01077-2%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%2290K%5C%2FLGALS3BP%20expression%20is%20upregulated%20in%20COVID-19%20but%20may%20not%20restrict%20SARS-CoV-2%20infection%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laure%22%2C%22lastName%22%3A%22Bosquillon%20De%20Jarcy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bengisu%22%2C%22lastName%22%3A%22Akbil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Baxolele%22%2C%22lastName%22%3A%22Mhlekude%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Leyens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dylan%22%2C%22lastName%22%3A%22Postmus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Greta%22%2C%22lastName%22%3A%22Harnisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenny%22%2C%22lastName%22%3A%22Jansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%20L.%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Aigner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Pott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%20Lorenz%22%2C%22lastName%22%3A%22Chua%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberta%22%2C%22lastName%22%3A%22Gentile%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22M%5Cu00fchlemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Terence%20C.%22%2C%22lastName%22%3A%22Jones%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Niemeyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Janke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Conrad%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Iacobelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Drosten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Victor%20M.%22%2C%22lastName%22%3A%22Corman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Ralser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roland%22%2C%22lastName%22%3A%22Eils%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Kurth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leif%22%2C%22lastName%22%3A%22Sander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Goffinet%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Glycoprotein%2090K%2C%20encoded%20by%20the%20interferon-stimulated%20gene%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2C%20displays%20broad%20antiviral%20activity.%20It%20reduces%20HIV-1%20infectivity%20by%20interfering%20with%20Env%20maturation%20and%20virion%20incorporation%2C%20and%20increases%20survival%20of%20Influenza%20A%20virus-infected%20mice%20via%20antiviral%20innate%20immune%20signaling.%20Its%20antiviral%20potential%20in%20SARS-CoV-2%20infection%20remains%20largely%20unknown.%20Here%2C%20we%20analyzed%20the%20expression%20of%2090K%5C%2F%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%2044%20hospitalized%20COVID-19%20patients%20at%20multiple%20levels.%20We%20quantified%2090K%20protein%20concentrations%20in%20serum%20and%20PBMCs%20as%20well%20as%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20mRNA%20levels.%20Complementary%2C%20we%20analyzed%20two%20single%20cell%20RNA-sequencing%20datasets%20for%20expression%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20respiratory%20specimens%20and%20PBMCs%20from%20COVID-19%20patients.%20Finally%2C%20we%20analyzed%20the%20potential%20of%2090K%20to%20interfere%20with%20SARS-CoV-2%20infection%20of%20HEK293T%5C%2FACE2%2C%20Calu-3%20and%20Caco-2%20cells%20using%20authentic%20virus.%2090K%20protein%20serum%20concentrations%20were%20significantly%20elevated%20in%20COVID-19%20patients%20compared%20to%20uninfected%20sex-%20and%20age-matched%20controls.%20Furthermore%2C%20PBMC-associated%20concentrations%20of%2090K%20protein%20were%20overall%20reduced%20by%20SARS-CoV-2%20infection%20in%20vivo%2C%20suggesting%20enhanced%20secretion%20into%20the%20extracellular%20space.%20Mining%20of%20published%20PBMC%20scRNA-seq%20datasets%20uncovered%20monocyte-specific%20induction%20of%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20mRNA%20expression%20in%20COVID-19%20patients.%20In%20functional%20assays%2C%20neither%2090K%20overexpression%20in%20susceptible%20cell%20lines%20nor%20exogenous%20addition%20of%20purified%2090K%20consistently%20inhibited%20SARS-CoV-2%20infection.%20Our%20data%20suggests%20that%2090K%5C%2F%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20LGALS3BP%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20contributes%20to%20the%20global%20type%20I%20IFN%20response%20during%20SARS-CoV-2%20infection%20in%20vivo%20without%20displaying%20detectable%20antiviral%20properties%20in%20vitro.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10238-023-01077-2%22%2C%22ISSN%22%3A%221591-9528%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs10238-023-01077-2%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T12%3A48%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22JUYRXYVR%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kettlitz%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKettlitz%20R%2C%20Harries%20M%2C%20Ortmann%20J%2C%20et%20al.%20Association%20of%20known%20SARS-CoV-2%20serostatus%20and%20adherence%20to%20personal%20protection%20measures%20and%20the%20impact%20of%20personal%20protective%20measures%20on%20seropositivity%20in%20a%20population-based%20cross-sectional%20study%20%28MuSPAD%29%20in%20Germany.%20%3Ci%3EBMC%20Public%20Health%3C%5C%2Fi%3E.%202023%3B23%281%29%3A2281.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-023-17121-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12889-023-17121-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20known%20SARS-CoV-2%20serostatus%20and%20adherence%20to%20personal%20protection%20measures%20and%20the%20impact%20of%20personal%20protective%20measures%20on%20seropositivity%20in%20a%20population-based%20cross-sectional%20study%20%28MuSPAD%29%20in%20Germany%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Kettlitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Harries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Ortmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22MuSPAD%20Team%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monika%22%2C%22lastName%22%3A%22Strengert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-Kirstin%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pilar%22%2C%22lastName%22%3A%22Hernandez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniela%22%2C%22lastName%22%3A%22Gornyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monike%22%2C%22lastName%22%3A%22Schl%5Cu00fcter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Kerrines%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Schneiderhan-Marra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alex%22%2C%22lastName%22%3A%22Dulovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Bojara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Frank%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Knut%22%2C%22lastName%22%3A%22Gubbe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Torsten%22%2C%22lastName%22%3A%22Tonn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kappert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Winfried%20V.%22%2C%22lastName%22%3A%22Kern%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Illig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norman%22%2C%22lastName%22%3A%22Klopp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gottfried%22%2C%22lastName%22%3A%22Roller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Ziemons%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gottfried%22%2C%22lastName%22%3A%22Rolle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Aigner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.%22%2C%22lastName%22%3A%22Lange%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%202020%5C%2F2021%20in%20Germany%2C%20several%20non-pharmacological%20interventions%20were%20introduced%20to%20lower%20the%20transmission%20of%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29.%20We%20investigated%20to%20what%20extent%20knowledge%20of%20prior%20infection%20with%20SARS-CoV-2%20or%20vaccination%20status%20influenced%20the%20use%20of%20personal%20protection%20measures%20%28PPM%29.%20Further%2C%20we%20were%20interested%20in%20the%20effect%20of%20compliance%20with%20PPM%20on%20SARS-CoV-2%20serostatus.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20was%20based%20on%20a%20sequential%2C%20multilocal%20seroprevalence%20study%20%28MuSPAD%29%2C%20carried%20out%20in%20eight%20locations%20from%20July%202020%20to%20August%202021.%20We%20estimated%20the%20association%20between%20a%20known%20SARS-CoV-2%20serostatus%20%28reported%20positive%20PCR%20test%20or%20vaccination%29%20and%20self-reported%20PPM%20behavior%20%28hand%20hygiene%2C%20physical%20distancing%2C%20wearing%20face%20mask%29%2C%20just%20as%20the%20association%20of%20PPM%20compliance%20with%20seropositivity%20against%20nucleocapsid%20%28NC%29%2C%20receptor-binding%20domain%20%28RBD%29%2C%20and%20spike%20protein%20%28S%29%20antigens.%20We%20identified%20relevant%20variables%20and%20deduced%20adjustment%20sets%20with%20directed%20acyclic%20graphs%20%28DAG%29%2C%20and%20applied%20mixed%20logistic%20regression.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Out%20of%20the%2022%2C297%20participants%20%28median%20age%3A%2054%5Cu00a0years%2C%2043%25%20male%29%2C%20781%20were%20classified%20as%20SARS-CoV-2-infected%20and%203%2C877%20had%20a%20vaccinated%20immune%20response.%20Vaccinated%20individuals%20were%20less%20likely%20to%20keep%201.5%5Cu00a0m%20distance%20%5BOR%5Cu2009%3D%5Cu20090.74%20%2895%25%20CI%3A%200.57%5Cu20130.97%29%5D%20and%20only%20partly%20physically%20distanced%20%5BOR%5Cu2009%3D%5Cu20090.71%20%2895%25%20CI%3A%200.58%5Cu20130.87%29%5D.%20Participants%20with%20self-reported%20positive%20PCR%20test%20had%20a%20lower%20chance%20of%20adhering%20partly%20to%20physical%20distancing%20%5BOR%5Cu2009%3D%5Cu20090.70%20%2895%25%20CI%3A%200.50%5Cu20130.99%29%5D%20in%20comparison%20to%20the%20reference%20group.%20Higher%20odds%20of%20additionally%20wearing%20a%20face%20mask%20was%20observed%20in%20vaccinated%20%5BOR%5Cu2009%3D%5Cu20091.28%20%2895%25%20CI%3A%201.08%5Cu20131.51%29%5D%20even%20if%20it%20was%20not%20obligatory.%20Overall%2C%20among%20unvaccinated%20participants%2C%20we%20found%20little%20evidence%20of%20lower%20odds%20of%20seropositivity%20given%20mask%20wearing%20%5BOR%3A%200.91%20%2895%25%20CI%3A%200.71%5Cu20131.16%29%5D%2C%20physical%20distancing%20%5BOR%3A%200.84%20%2895%25%20CI%3A%200.59%5Cu20131.20%29%5D%20and%20no%20evidence%20for%20completely%20adhering%20to%20hand%20cleaning%20%5BOR%3A%200.97%20%2895%25%20CI%3A%200.29%5Cu20133.22%29%5D.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20known%20confirmed%20prior%20infection%20and%20vaccination%20may%20have%20the%20potential%20to%20influence%20adherence%20to%20PPM.%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12889-023-17121-5%22%2C%22ISSN%22%3A%221471-2458%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcpublichealth.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12889-023-17121-5%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T12%3A45%3A48Z%22%7D%7D%2C%7B%22key%22%3A%222TYXNKID%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Berger%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBerger%20K%2C%20Rietschel%20M%2C%20Rujescu%20D.%20The%20value%20of%20%26%23x2018%3Bmega%20cohorts%26%23x2019%3B%20for%20psychiatric%20research.%20%3Ci%3EThe%20World%20Journal%20of%20Biological%20Psychiatry%3C%5C%2Fi%3E.%202023%3B24%2810%29%3A860-864.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011405%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F15622975.2021.2011405%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20value%20of%20%5Cu2018mega%20cohorts%5Cu2019%20for%20psychiatric%20research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rujescu%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F15622975.2021.2011405%22%2C%22ISSN%22%3A%221562-2975%2C%201814-1412%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F15622975.2021.2011405%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-24T14%3A59%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22GWXH59SX%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fay%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFay%20L%2C%20Cobos%20E%2C%20Yang%20B%2C%20Gatidis%20S%2C%20K%26%23xFC%3Bstner%20T.%20Avoiding%20Shortcut-Learning%20by%20Mutual%20Information%20Minimization%20in%20Deep%20Learning-Based%20Image%20Processing.%20%3Ci%3EIEEE%20Access%3C%5C%2Fi%3E.%202023%3B11%3A64070-64086.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FACCESS.2023.3289397%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1109%5C%2FACCESS.2023.3289397%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Avoiding%20Shortcut-Learning%20by%20Mutual%20Information%20Minimization%20in%20Deep%20Learning-Based%20Image%20Processing%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louisa%22%2C%22lastName%22%3A%22Fay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erick%22%2C%22lastName%22%3A%22Cobos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1109%5C%2FACCESS.2023.3289397%22%2C%22ISSN%22%3A%222169-3536%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fieeexplore.ieee.org%5C%2Fdocument%5C%2F10162210%5C%2F%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-10T10%3A48%3A04Z%22%7D%7D%5D%7D
1.
Schmiedek F, Kroehne U, Goldhammer F, et al. General cognitive ability assessment in the German National Cohort (NAKO) – The block-adaptive number series task. The World Journal of Biological Psychiatry. 2023;24(10):924-935. http://doi.org/10.1080/15622975.2021.2011407
1.
Streit F, Zillich L, Frank J, et al. Lifetime and current depression in the German National Cohort (NAKO). The World Journal of Biological Psychiatry. 2023;24(10):865-880. http://doi.org/10.1080/15622975.2021.2014152
1.
Huemer MT, Kluttig A, Fischer B, et al. Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points. Age and Ageing. 2023;52(1):afac324. http://doi.org/10.1093/ageing/afac324
1.
Ortmann J, Heise JK, Janzen I, et al. Suitability and user acceptance of the eResearch system “Prospective Monitoring and Management App (PIA)”—The example of an epidemiological study on infectious diseases. Page K, ed. PLoS ONE. 2023;18(1):e0279969. http://doi.org/10.1371/journal.pone.0279969
1.
Merz S, Jaehn P, Pischon T, et al. Investigating people’s attitudes towards participating in longitudinal health research: an intersectionality-informed perspective. Int J Equity Health. 2023;22(1):23. http://doi.org/10.1186/s12939-022-01807-0
1.
Gatidis S, Kart T, Fischer M, et al. Better Together: Data Harmonization and Cross-Study Analysis of Abdominal MRI Data From UK Biobank and the German National Cohort. Invest Radiol. 2023;58(5):346-354. http://doi.org/10.1097/RLI.0000000000000941
1.
Haueise T, Schick F, Stefan N, et al. Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort. Sci Adv. 2023;9(19):eadd0433. http://doi.org/10.1126/sciadv.add0433
1.
Streit F, Völker MP, Klinger-König J, et al. The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO). Front Epidemiol. 2023;3:1099235. http://doi.org/10.3389/fepid.2023.1099235
1.
Ewendt F, Schmitt M, Kluttig A, et al. Association between vitamin D status and eryptosis–results from the German National Cohort Study. Ann Hematol. 2023;102(6):1351-1361. http://doi.org/10.1007/s00277-023-05239-w
1.
Vonneilich N, Becher H, Bohn B, et al. Associations of Migration, Socioeconomic Position and Social Relations With Depressive Symptoms – Analyses of the German National Cohort Baseline Data. Int J Public Health. 2023;68:1606097. http://doi.org/10.3389/ijph.2023.1606097
1.
Fischer M, Küstner T, Pappa S, et al. Identification of radiomic biomarkers in a set of four skeletal muscle groups on Dixon MRI of the NAKO MR study. BMC Med Imaging. 2023;23(1):104. http://doi.org/10.1186/s12880-023-01056-9
1.
Koschig M, Conrad I, Berger K, et al. The mediating role of personality traits in the association between childhood trauma and depressive symptoms in young adulthood. Journal of Affective Disorders. 2023;338:373-379. http://doi.org/10.1016/j.jad.2023.06.027
1.
Erhardt A, Gelbrich G, Klinger-König J, et al. Generalised anxiety and panic symptoms in the German National Cohort (NAKO). The World Journal of Biological Psychiatry. 2023;24(10):881-896. http://doi.org/10.1080/15622975.2021.2011409
1.
Kleineidam L, Stark M, Riedel-Heller SG, et al. The assessment of cognitive function in the German National Cohort (NAKO) – Associations of demographics and psychiatric symptoms with cognitive test performance. The World Journal of Biological Psychiatry. 2023;24(10):909-923. http://doi.org/10.1080/15622975.2021.2011408
1.
Klinger-König J, Streit F, Erhardt A, et al. The assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO). The World Journal of Biological Psychiatry. 2023;24(10):897-908. http://doi.org/10.1080/15622975.2021.2011406
1.
Hassenstein MJ, Pischon T, Karch A, et al. Seropositivity of Borrelia burgdorferi s.l. in Germany—an analysis across four German National Cohort (NAKO) study sites. Sci Rep. 2023;13(1):21087. http://doi.org/10.1038/s41598-023-47766-6
1.
Schuppert C, Rospleszcz S, Hirsch JG, et al. Automated image quality assessment for selecting among multiple magnetic resonance image acquisitions in the German National Cohort study. Sci Rep. 2023;13(1):22745. http://doi.org/10.1038/s41598-023-49569-1
1.
Bosquillon De Jarcy L, Akbil B, Mhlekude B, et al. 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection. Clin Exp Med. 2023;23(7):3689-3700. http://doi.org/10.1007/s10238-023-01077-2
1.
Kettlitz R, Harries M, Ortmann J, et al. Association of known SARS-CoV-2 serostatus and adherence to personal protection measures and the impact of personal protective measures on seropositivity in a population-based cross-sectional study (MuSPAD) in Germany. BMC Public Health. 2023;23(1):2281. http://doi.org/10.1186/s12889-023-17121-5
1.
Berger K, Rietschel M, Rujescu D. The value of ‘mega cohorts’ for psychiatric research. The World Journal of Biological Psychiatry. 2023;24(10):860-864. http://doi.org/10.1080/15622975.2021.2011405
1.
Fay L, Cobos E, Yang B, Gatidis S, Küstner T. Avoiding Shortcut-Learning by Mutual Information Minimization in Deep Learning-Based Image Processing. IEEE Access. 2023;11:64070-64086. http://doi.org/10.1109/ACCESS.2023.3289397
5565830
2022
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NWUMPWZG%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reuter%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EReuter%20M%2C%20Rig%26%23xF3%3B%20M%2C%20Formazin%20M%2C%20et%20al.%20Authors%26%23x2019%3B%20response%3A%20Occupation%20and%20SARS-CoV-2%20infection%20risk%20among%20workers%20during%20the%20first%20pandemic%20wave%20in%20Germany%3A%20potential%20for%20bias.%20%3Ci%3EScand%20J%20Work%20Environ%20Health%3C%5C%2Fi%3E.%202022%3B48%287%29%3A588-590.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5271%5C%2Fsjweh.4061%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5271%5C%2Fsjweh.4061%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Authors%27%20response%3A%20Occupation%20and%20SARS-CoV-2%20infection%20risk%20among%20workers%20during%20the%20first%20pandemic%20wave%20in%20Germany%3A%20potential%20for%20bias%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariann%22%2C%22lastName%22%3A%22Rig%5Cu00f3%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maren%22%2C%22lastName%22%3A%22Formazin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Falk%22%2C%22lastName%22%3A%22Liebers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ute%22%2C%22lastName%22%3A%22Latza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Albrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilter%22%2C%22lastName%22%3A%22%5Cu00d6zt%5Cu00fcrk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%20Mj%22%2C%22lastName%22%3A%22Lampl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karla%20Romero%22%2C%22lastName%22%3A%22Starke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Seidler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Klee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20Deckert%22%2C%22lastName%22%3A%22Andreas%20Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.5271%5C%2Fsjweh.4061%22%2C%22ISSN%22%3A%220355-3140%2C%201795-990X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sjweh.fi%5C%2Fshow_abstract.php%3Fabstract_id%3D4061%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A08%3A35Z%22%7D%7D%2C%7B%22key%22%3A%224FWA8FL3%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rickmann%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERickmann%20AM%2C%20Senapati%20J%2C%20Kovalenko%20O%2C%20Peters%20A%2C%20Bamberg%20F%2C%20Wachinger%20C.%20AbdomenNet%3A%20deep%20neural%20network%20for%20abdominal%20organ%20segmentation%20in%20epidemiologic%20imaging%20studies.%20%3Ci%3EBMC%20Med%20Imaging%3C%5C%2Fi%3E.%202022%3B22%281%29%3A168.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12880-022-00893-4%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12880-022-00893-4%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22AbdomenNet%3A%20deep%20neural%20network%20for%20abdominal%20organ%20segmentation%20in%20epidemiologic%20imaging%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Marie%22%2C%22lastName%22%3A%22Rickmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jyotirmay%22%2C%22lastName%22%3A%22Senapati%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oksana%22%2C%22lastName%22%3A%22Kovalenko%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wachinger%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Whole-body%20imaging%20has%20recently%20been%20added%20to%20large-scale%20epidemiological%20studies%20providing%20novel%20opportunities%20for%20investigating%20abdominal%20organs.%20However%2C%20the%20segmentation%20of%20these%20organs%20is%20required%20beforehand%2C%20which%20is%20time%20consuming%2C%20particularly%20on%20such%20a%20large%20scale.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20introduce%20AbdomentNet%2C%20a%20deep%20neural%20network%20for%20the%20automated%20segmentation%20of%20abdominal%20organs%20on%20two-point%20Dixon%20MRI%20scans.%20A%20pre-processing%20pipeline%20enables%20to%20process%20MRI%20scans%20from%20different%20imaging%20studies%2C%20namely%20the%20German%20National%20Cohort%2C%20UK%20Biobank%2C%20and%20Kohorte%20im%20Raum%20Augsburg.%20We%20chose%20a%20total%20of%2061%20MRI%20scans%20across%20the%20three%20studies%20for%20training%20an%20ensemble%20of%20segmentation%20networks%2C%20which%20segment%20eight%20abdominal%20organs.%20Our%20network%20presents%20a%20novel%20combination%20of%20octave%20convolutions%20and%20squeeze%20and%20excitation%20layers%2C%20as%20well%20as%20training%20with%20stochastic%20weight%20averaging.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20experiments%20demonstrate%20that%20it%20is%20beneficial%20to%20combine%20data%20from%20different%20imaging%20studies%20to%20train%20deep%20neural%20networks%20in%20contrast%20to%20training%20separate%20networks.%20Combining%20the%20water%20and%20opposed-phase%20contrasts%20of%20the%20Dixon%20sequence%20as%20input%20channels%2C%20yields%20the%20highest%20segmentation%20accuracy%2C%20compared%20to%20single%20contrast%20inputs.%20The%20mean%20Dice%20similarity%20coefficient%20is%20above%200.9%20for%20larger%20organs%20liver%2C%20spleen%2C%20and%20kidneys%2C%20and%200.71%20and%200.74%20for%20gallbladder%20and%20pancreas%2C%20respectively.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20fully%20automated%20pipeline%20provides%20high-quality%20segmentations%20of%20abdominal%20organs%20across%20population%20studies.%20In%20contrast%2C%20a%20network%20that%20is%20only%20trained%20on%20a%20single%20dataset%20does%20not%20generalize%20well%20to%20other%20datasets.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12880-022-00893-4%22%2C%22ISSN%22%3A%221471-2342%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcmedimaging.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12880-022-00893-4%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A08%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22LGT4TFCU%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Streckenbach%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStreckenbach%20F%2C%20Leifert%20G%2C%20Beyer%20T%2C%20et%20al.%20Application%20of%20a%20Deep%20Learning%20Approach%20to%20Analyze%20Large-Scale%20MRI%20Data%20of%20the%20Spine.%20%3Ci%3EHealthcare%3C%5C%2Fi%3E.%202022%3B10%2811%29%3A2132.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fhealthcare10112132%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fhealthcare10112132%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Application%20of%20a%20Deep%20Learning%20Approach%20to%20Analyze%20Large-Scale%20MRI%20Data%20of%20the%20Spine%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Streckenbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gundram%22%2C%22lastName%22%3A%22Leifert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Beyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anita%22%2C%22lastName%22%3A%22Mesanovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%22%2C%22lastName%22%3A%22W%5Cu00e4scher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Cantr%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00f6nke%22%2C%22lastName%22%3A%22Langner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc-Andr%5Cu00e9%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Lindner%22%7D%5D%2C%22abstractNote%22%3A%22With%20its%20standardized%20MRI%20datasets%20of%20the%20entire%20spine%2C%20the%20German%20National%20Cohort%20%28GNC%29%20has%20the%20potential%20to%20deliver%20standardized%20biometric%20reference%20values%20for%20intervertebral%20discs%20%28VD%29%2C%20vertebral%20bodies%20%28VB%29%20and%20spinal%20canal%20%28SC%29.%20To%20handle%20such%20large-scale%20big%20data%2C%20artificial%20intelligence%20%28AI%29%20tools%20are%20needed.%20In%20this%20manuscript%2C%20we%20will%20present%20an%20AI%20software%20tool%20to%20analyze%20spine%20MRI%20and%20generate%20normative%20standard%20values.%20330%20representative%20GNC%20MRI%20datasets%20were%20randomly%20selected%20in%20equal%20distribution%20regarding%20parameters%20of%20age%2C%20sex%20and%20height.%20By%20using%20a%203D%20U-Net%2C%20an%20AI%20algorithm%20was%20trained%2C%20validated%20and%20tested.%20Finally%2C%20the%20machine%20learning%20algorithm%20explored%20the%20full%20dataset%20%28n%20%3D%2010%2C215%29.%20VB%2C%20VD%20and%20SC%20were%20successfully%20segmented%20and%20analyzed%20by%20using%20an%20AI-based%20algorithm.%20A%20software%20tool%20was%20developed%20to%20analyze%20spine-MRI%20and%20provide%20age%2C%20sex%2C%20and%20height-matched%20comparative%20biometric%20data.%20Using%20an%20AI%20algorithm%2C%20the%20reliable%20segmentation%20of%20MRI%20datasets%20of%20the%20entire%20spine%20from%20the%20GNC%20was%20possible%20and%20achieved%20an%20excellent%20agreement%20with%20manually%20segmented%20datasets.%20With%20the%20analysis%20of%20the%20total%20GNC%20MRI%20dataset%20with%20almost%2030%2C000%20subjects%2C%20it%20will%20be%20possible%20to%20generate%20real%20normative%20standard%20values%20in%20the%20future.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fhealthcare10112132%22%2C%22ISSN%22%3A%222227-9032%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2227-9032%5C%2F10%5C%2F11%5C%2F2132%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A08%3A19Z%22%7D%7D%2C%7B%22key%22%3A%22TJTPGZHI%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tanoey%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ETanoey%20J%2C%20Baechle%20C%2C%20Brenner%20H%2C%20et%20al.%20Birth%20Order%2C%20Caesarean%20Section%2C%20or%20Daycare%20Attendance%20in%20Relation%20to%20Child-%20and%20Adult-Onset%20Type%201%20Diabetes%3A%20Results%20from%20the%20German%20National%20Cohort.%20%3Ci%3EIJERPH%3C%5C%2Fi%3E.%202022%3B19%2817%29%3A10880.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph191710880%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph191710880%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Birth%20Order%2C%20Caesarean%20Section%2C%20or%20Daycare%20Attendance%20in%20Relation%20to%20Child-%20and%20Adult-Onset%20Type%201%20Diabetes%3A%20Results%20from%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Justine%22%2C%22lastName%22%3A%22Tanoey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22Baechle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%20M.%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%20S.%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Verena%22%2C%22lastName%22%3A%22Katzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%5D%2C%22abstractNote%22%3A%22%281%29%20Background%3A%20Global%20incidence%20of%20type%201%20diabetes%20%28T1D%29%20is%20rising%20and%20nearly%20half%20occurred%20in%20adults.%20However%2C%20it%20is%20unclear%20if%20certain%20early-life%20childhood%20T1D%20risk%20factors%20were%20also%20associated%20with%20adult-onset%20T1D.%20This%20study%20aimed%20to%20assess%20associations%20between%20birth%20order%2C%20delivery%20mode%20or%20daycare%20attendance%20and%20type%201%20diabetes%20%28T1D%29%20risk%20in%20a%20population-based%20cohort%20and%20whether%20these%20were%20similar%20for%20childhood-%20and%20adult-onset%20T1D%20%28cut-off%20age%2015%29%3B%20%282%29%20Methods%3A%20Data%20were%20obtained%20from%20the%20German%20National%20Cohort%20%28NAKO%20Gesundheitsstudie%29%20baseline%20assessment.%20Self-reported%20diabetes%20was%20classified%20as%20T1D%20if%3A%20diagnosis%20age%20%5Cu2264%2040%20years%20and%20has%20been%20receiving%20insulin%20treatment%20since%20less%20than%20one%20year%20after%20diagnosis.%20Cox%20regression%20was%20applied%20for%20T1D%20risk%20analysis%3B%20%283%29%20Results%3A%20Analyses%20included%20101%2C411%20participants%20%28100%20childhood-%20and%20271%20adult-onset%20T1D%20cases%29.%20Compared%20to%20%5Cu201conly-children%5Cu201d%2C%20HRs%20for%20second-%20or%20later-born%20individuals%20were%200.70%20%2895%25%20CI%20%3D%200.50%5Cu20130.96%29%20and%200.65%20%2895%25%20CI%20%3D%200.45%5Cu20130.94%29%2C%20respectively%2C%20regardless%20of%20parental%20diabetes%2C%20migration%20background%2C%20birth%20year%20and%20perinatal%20factors.%20In%20further%20analyses%2C%20higher%20birth%20order%20reduced%20T1D%20risk%20in%20children%20and%20adults%20born%20in%20recent%20decades.%20Caesarean%20section%20and%20daycare%20attendance%20showed%20no%20clear%20associations%20with%20T1D%20risk%3B%20%284%29%20Conclusions%3A%20Birth%20order%20should%20be%20considered%20in%20both%20children%20and%20adults%5Cu2019%20T1D%20risk%20assessment%20for%20early%20detection.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fijerph191710880%22%2C%22ISSN%22%3A%221660-4601%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F19%5C%2F17%5C%2F10880%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A08%3A13Z%22%7D%7D%2C%7B%22key%22%3A%2226N7L8JD%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wienbergen%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWienbergen%20H%2C%20Boakye%20D%2C%20G%26%23xFC%3Bnther%20K%2C%20et%20al.%20Lifestyle%20and%20metabolic%20risk%20factors%20in%20patients%20with%20early-onset%20myocardial%20infarction%3A%20a%20case-control%20study.%20%3Ci%3EEuropean%20Journal%20of%20Preventive%20Cardiology%3C%5C%2Fi%3E.%202022%3B29%2816%29%3A2076-2087.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Feurjpc%5C%2Fzwac132%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Feurjpc%5C%2Fzwac132%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lifestyle%20and%20metabolic%20risk%20factors%20in%20patients%20with%20early-onset%20myocardial%20infarction%3A%20a%20case-control%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harm%22%2C%22lastName%22%3A%22Wienbergen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Boakye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Schmucker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luis%20Alberto%22%2C%22lastName%22%3A%22Mata%20Mar%5Cu00edn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hatim%22%2C%22lastName%22%3A%22Kerniss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rajini%22%2C%22lastName%22%3A%22Nagrani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luise%22%2C%22lastName%22%3A%22Stru%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22R%5Cu00fchle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tina%22%2C%22lastName%22%3A%22Retzlaff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Fach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rico%22%2C%22lastName%22%3A%22Osteresch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rainer%22%2C%22lastName%22%3A%22Hambrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Aims%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Family%20history%20is%20a%20known%20risk%20factor%20for%20early-onset%20myocardial%20infarction%20%28EOMI%29.%20However%2C%20the%20role%20of%20modifiable%20lifestyle%20and%20metabolic%20factors%20in%20EOMI%20risk%20is%20unclear%20and%20may%20differ%20from%20that%20of%20older%20adults.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20case-control%20study%20included%20myocardial%20infarction%20%28MI%29%20patients%20aged%20%5Cu226445%20years%20from%20the%20Bremen%20ST-elevation%20MI%20Registry%20and%20matched%20controls%20randomly%20selected%20from%20the%20general%20population%20%28German%20National%20Cohort%29%20at%20the%20same%20geographical%20region.%20Multiple%20logistic%20regression%20was%20used%20to%20estimate%20odds%20ratios%20%28ORs%29%20and%2095%25%20confidence%20intervals%20%28CIs%29%20for%20the%20individual%20and%20combined%20associations%20of%20lifestyle%20and%20metabolic%20factors%20with%20EOMI%20risk%2C%20overall%20and%20according%20to%20family%20history%20for%20premature%20MI.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20total%20of%20522%20cases%20and%201191%20controls%20were%20included.%20Hypertension%2C%20current%20smoking%2C%20elevated%20waist-to-hip%20ratio%2C%20and%20diabetes%20mellitus%20were%20strongly%20associated%20with%20the%20occurrence%20of%20EOMI.%20By%20contrast%2C%20higher%20frequency%20of%20alcohol%20consumption%20was%20associated%20with%20decreased%20EOMI%20risk.%20In%20a%20combined%20analysis%20of%20the%20risk%20factors%20hypertension%2C%20current%20smoking%2C%20body%20mass%20index%20%5Cu226525.0%5Cu2005kg%5C%2Fsqm%2C%20and%20diabetes%20mellitus%2C%20participants%20having%20one%20%28OR%20%3D%205.4%2C%2095%25CI%20%3D%202.9%5Cu201310.1%29%20and%20two%20or%20more%20risk%20factors%20%28OR%20%3D%2042.3%2C%2095%25CI%20%3D%2022.3%5Cu201380.4%29%20had%20substantially%20higher%20odds%20of%20EOMI%20compared%20to%20those%20with%20none%20of%20these%20risk%20factors%2C%20regardless%20of%20their%20family%20history.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20study%20demonstrates%20a%20strong%20association%20of%20smoking%20and%20metabolic%20risk%20factors%20with%20the%20occurrence%20of%20EOMI.%20The%20data%20suggest%20that%20the%20risk%20of%20EOMI%20goes%20beyond%20family%20history%20and%20underlines%20the%20importance%20of%20primary%20prevention%20efforts%20to%20reduce%20smoking%20and%20metabolic%20syndrome%20in%20young%20persons.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Feurjpc%5C%2Fzwac132%22%2C%22ISSN%22%3A%222047-4873%2C%202047-4881%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Feurjpc%5C%2Farticle%5C%2F29%5C%2F16%5C%2F2076%5C%2F6625924%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A08%3A04Z%22%7D%7D%2C%7B%22key%22%3A%224SJQ8EUY%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hahn%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHahn%20T%2C%20Ernsting%20J%2C%20Winter%20NR%2C%20et%20al.%20An%20uncertainty-aware%2C%20shareable%2C%20and%20transparent%20neural%20network%20architecture%20for%20brain-age%20modeling.%20%3Ci%3ESci%20Adv%3C%5C%2Fi%3E.%202022%3B8%281%29%3Aeabg9471.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.abg9471%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fsciadv.abg9471%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20uncertainty-aware%2C%20shareable%2C%20and%20transparent%20neural%20network%20architecture%20for%20brain-age%20modeling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Hahn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Ernsting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nils%20R.%22%2C%22lastName%22%3A%22Winter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Holstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Leenings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie%22%2C%22lastName%22%3A%22Beisemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelvin%22%2C%22lastName%22%3A%22Sarink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Emden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nils%22%2C%22lastName%22%3A%22Opel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronny%22%2C%22lastName%22%3A%22Redlich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%22%2C%22lastName%22%3A%22Repple%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Grotegerd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Meinert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochen%20G.%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Endemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oyunbileg%22%2C%22lastName%22%3A%22Von%20Stackelberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%20Felizitas%22%2C%22lastName%22%3A%22Sowade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lale%22%2C%22lastName%22%3A%22Umutlu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Svenja%22%2C%22lastName%22%3A%22Caspers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Harald%22%2C%22lastName%22%3A%22Kugel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tilo%22%2C%22lastName%22%3A%22Kircher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Risse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Gaser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20H.%22%2C%22lastName%22%3A%22Cole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Dannlowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%5D%2C%22abstractNote%22%3A%22A%20network-based%20quantification%20of%20brain%20aging%20uncovers%20and%20fixes%20a%20fundamental%20problem%20of%20all%20previous%20approaches.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20deviation%20between%20chronological%20age%20and%20age%20predicted%20from%20neuroimaging%20data%20has%20been%20identified%20as%20a%20sensitive%20risk%20marker%20of%20cross-disorder%20brain%20changes%2C%20growing%20into%20a%20cornerstone%20of%20biological%20age%20research.%20However%2C%20machine%20learning%20models%20underlying%20the%20field%20do%20not%20consider%20uncertainty%2C%20thereby%20confounding%20results%20with%20training%20data%20density%20and%20variability.%20Also%2C%20existing%20models%20are%20commonly%20based%20on%20homogeneous%20training%20sets%2C%20often%20not%20independently%20validated%2C%20and%20cannot%20be%20shared%20because%20of%20data%20protection%20issues.%20Here%2C%20we%20introduce%20an%20uncertainty-aware%2C%20shareable%2C%20and%20transparent%20Monte%20Carlo%20dropout%20composite%20quantile%20regression%20%28MCCQR%29%20Neural%20Network%20trained%20on%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20N%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3D%2010%2C691%20datasets%20from%20the%20German%20National%20Cohort.%20The%20MCCQR%20model%20provides%20robust%2C%20distribution-free%20uncertainty%20quantification%20in%20high-dimensional%20neuroimaging%20data%2C%20achieving%20lower%20error%20rates%20compared%20with%20existing%20models.%20In%20two%20examples%2C%20we%20demonstrate%20that%20it%20prevents%20spurious%20associations%20and%20increases%20power%20to%20detect%20deviant%20brain%20aging.%20We%20make%20the%20pretrained%20model%20and%20code%20publicly%20available.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fsciadv.abg9471%22%2C%22ISSN%22%3A%222375-2548%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.science.org%5C%2Fdoi%5C%2F10.1126%5C%2Fsciadv.abg9471%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T15%3A03%3A23Z%22%7D%7D%2C%7B%22key%22%3A%22GFBI58QV%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kuss%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKuss%20O%2C%20Becher%20H%2C%20Wienke%20A%2C%20et%20al.%20Statistical%20Analysis%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%26%23x2013%3B%20Specific%20Aspects%20and%20General%20Recommendations.%20%3Ci%3EEur%20J%20Epidemiol%3C%5C%2Fi%3E.%202022%3B37%284%29%3A429-436.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10654-022-00880-7%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10654-022-00880-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Statistical%20Analysis%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20%5Cu2013%20Specific%20Aspects%20and%20General%20Recommendations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Wienke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Till%22%2C%22lastName%22%3A%22Ittermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Ostrzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20O%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie%22%2C%22lastName%22%3A%22Roll%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Sand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Pohlabeln%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%20A%22%2C%22lastName%22%3A%22Mueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Werdecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronny%22%2C%22lastName%22%3A%22Westerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20H%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B%22%2C%22lastName%22%3A%22Michels%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20%28NAKO%29%20is%20an%20ongoing%2C%20prospective%20multicenter%20cohort%20study%2C%20which%20started%20recruitment%20in%202014%20and%20includes%20more%20than%20205%2C000%20women%20and%20men%20aged%2019%5Cu201374%20years.%20The%20study%20data%20will%20be%20available%20to%20the%20global%20research%20community%20for%20analyses.%20Although%20the%20ultimate%20decision%20about%20the%20analytic%20methods%20will%20be%20made%20by%20the%20respective%20investigator%2C%20in%20this%20paper%20we%20provide%20the%20basis%20for%20a%20harmonized%20approach%20to%20the%20statistical%20analyses%20in%20the%20NAKO.%20We%20discuss%20specific%20aspects%20of%20the%20study%20%28e.g.%2C%20data%20collection%2C%20weighting%20to%20account%20for%20the%20sampling%20design%29%2C%20but%20also%20give%20general%20recommendations%20which%20may%20apply%20to%20other%20large%20cohort%20studies%20as%20well.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10654-022-00880-7%22%2C%22ISSN%22%3A%220393-2990%2C%201573-7284%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs10654-022-00880-7%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T15%3A02%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22CFE8ZBMH%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schuppert%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchuppert%20C%2C%20Kr%26%23xFC%3Bchten%20RV%2C%20Hirsch%20JG%2C%20et%20al.%20Whole-Body%20Magnetic%20Resonance%20Imaging%20in%20the%20Large%20Population-Based%20German%20National%20Cohort%20Study%3A%20Predictive%20Capability%20of%20Automated%20Image%20Quality%20Assessment%20for%20Protocol%20Repetitions.%20%3Ci%3EInvest%20Radiol%3C%5C%2Fi%3E.%202022%3B57%287%29%3A478-487.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000861%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000861%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Whole-Body%20Magnetic%20Resonance%20Imaging%20in%20the%20Large%20Population-Based%20German%20National%20Cohort%20Study%3A%20Predictive%20Capability%20of%20Automated%20Image%20Quality%20Assessment%20for%20Protocol%20Repetitions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%22%2C%22lastName%22%3A%22Schuppert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ricarda%20Von%22%2C%22lastName%22%3A%22Kr%5Cu00fcchten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochen%20G.%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Rospleszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%20C.%22%2C%22lastName%22%3A%22Hoinkiss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Selder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22K%5Cu00f6hn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oyunbileg%20Von%22%2C%22lastName%22%3A%22Stackelberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Forsting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Hosten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Hendel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22for%20The%20German%20National%20Cohort%20MRI%20Study%20Investigators%22%7D%5D%2C%22abstractNote%22%3A%22Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Reproducible%20image%20quality%20is%20of%20high%20relevance%20for%20large%20cohort%20studies%20and%20can%20be%20challenging%20for%20magnetic%20resonance%20imaging%20%28MRI%29.%20Automated%20image%20quality%20assessment%20may%20contribute%20to%20conducting%20radiologic%20studies%20effectively.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Purpose%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20aims%20of%20this%20study%20were%20to%20assess%20protocol%20repetition%20frequency%20in%20population-based%20whole-body%20MRI%20along%20with%20its%20effect%20on%20examination%20time%20and%20to%20examine%20the%20applicability%20of%20automated%20image%20quality%20assessment%20for%20predicting%20decision-making%20regarding%20repeated%20acquisitions.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20All%20participants%20enrolled%20in%20the%20prospective%2C%20multicenter%20German%20National%20Cohort%20%28NAKO%29%20study%20who%20underwent%20whole-body%20MRI%20at%201%20of%205%20sites%20from%202014%20to%202016%20were%20included%20in%20this%20analysis%20%28n%20%3D%2011%2C347%29.%20A%20standardized%20examination%20program%20of%2012%20protocols%20was%20used.%20Acquisitions%20were%20carried%20out%20by%20certified%20radiologic%20technologists%2C%20who%20were%20authorized%20to%20repeat%20protocols%20based%20on%20their%20visual%20perception%20of%20image%20quality.%20Eleven%20image%20quality%20parameters%20were%20derived%20fully%20automatically%20from%20the%20acquired%20images%2C%20and%20their%20discrimination%20ability%20regarding%20baseline%20acquisitions%20and%20repetitions%20was%20tested.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20At%20least%201%20protocol%20was%20repeated%20in%2012%25%20%28n%20%3D%201359%29%20of%20participants%2C%20and%20more%20than%201%20protocol%20in%201.6%25%20%28n%20%3D%20181%29.%20The%20repetition%20frequency%20differed%20across%20protocols%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%2C%20imaging%20sites%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%2C%20and%20over%20the%20study%20period%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29.%20The%20mean%20total%20scan%20time%20was%2062.6%20minutes%20in%20participants%20without%20and%2067.4%20minutes%20in%20participants%20with%20protocol%20repetitions%20%28mean%20difference%2C%204.8%20minutes%3B%2095%25%20confidence%20interval%2C%204.5%5Cu20135.2%20minutes%29.%20Ten%20of%20the%20automatically%20derived%20image%20quality%20parameters%20were%20individually%20retrospectively%20predictive%20for%20the%20repetition%20of%20particular%20protocols%3B%20for%20instance%2C%20%5Cu201csignal-to-noise%20ratio%5Cu201d%20alone%20provided%20an%20area%20under%20the%20curve%20of%200.65%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%20for%20repetition%20of%20the%20Cardio%20Cine%20SSFP%20SAX%20protocol.%20Combinations%20generally%20improved%20prediction%20ability%2C%20as%20exemplified%20by%20%5Cu201cimage%20sharpness%5Cu201d%20plus%20%5Cu201cforeground%20ratio%5Cu201d%20yielding%20an%20area%20under%20the%20curve%20of%200.89%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%20for%20repetition%20of%20the%20Neuro%20T1w%203D%20MPRAGE%20protocol%2C%20versus%200.85%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%20and%200.68%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20P%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3C%200.001%29%20as%20individual%20parameters.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Magnetic%20resonance%20imaging%20protocol%20repetitions%20were%20necessary%20in%20approximately%2012%25%20of%20scans%20even%20in%20the%20highly%20standardized%20setting%20of%20a%20large%20cohort%20study.%20Automated%20image%20quality%20assessment%20shows%20predictive%20value%20for%20the%20technologists%27%20decision%20to%20perform%20protocol%20repetitions%20and%20has%20the%20potential%20to%20improve%20imaging%20efficiency.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FRLI.0000000000000861%22%2C%22ISSN%22%3A%221536-0210%2C%200020-9996%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2F10.1097%5C%2FRLI.0000000000000861%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T15%3A00%3A47Z%22%7D%7D%2C%7B%22key%22%3A%22KKZ5BQAC%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Reuter%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EReuter%20M%2C%20Rig%26%23xF3%3B%20M%2C%20Formazin%20M%2C%20et%20al.%20Occupation%20and%20SARS-CoV-2%20infection%20risk%20among%20108%20960%20workers%20during%20the%20first%20pandemic%20wave%20in%20Germany.%20%3Ci%3EScand%20J%20Work%20Environ%20Health%3C%5C%2Fi%3E.%202022%3B48%286%29%3A446-456.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5271%5C%2Fsjweh.4037%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5271%5C%2Fsjweh.4037%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Occupation%20and%20SARS-CoV-2%20infection%20risk%20among%20108%20960%20workers%20during%20the%20first%20pandemic%20wave%20in%20Germany%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariann%22%2C%22lastName%22%3A%22Rig%5Cu00f3%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maren%22%2C%22lastName%22%3A%22Formazin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Falk%22%2C%22lastName%22%3A%22Liebers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ute%22%2C%22lastName%22%3A%22Latza%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Albrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilter%22%2C%22lastName%22%3A%22%5Cu00d6zt%5Cu00fcrk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%20Mj%22%2C%22lastName%22%3A%22Lampl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karla%20Romero%22%2C%22lastName%22%3A%22Starke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Seidler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Klee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Deckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.5271%5C%2Fsjweh.4037%22%2C%22ISSN%22%3A%220355-3140%2C%201795-990X%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.sjweh.fi%5C%2Fshow_abstract.php%3Fabstract_id%3D4037%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A59%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22VLJR9544%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jaeschke%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJaeschke%20L%2C%20Becher%20M%2C%20Vel%26%23xE1%3Bsquez%20IM%2C%20et%20al.%20The%20bias%20from%20heaping%20on%20risk%20estimation%3A%20effect%20of%20age%20at%20diagnosis%20of%20hypertension%20on%20risk%20of%20subsequent%20cardiovascular%20comorbidities.%20%3Ci%3EAnnals%20of%20Epidemiology%3C%5C%2Fi%3E.%202022%3B74%3A84-96.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annepidem.2022.07.012%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.annepidem.2022.07.012%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20bias%20from%20heaping%20on%20risk%20estimation%3A%20effect%20of%20age%20at%20diagnosis%20of%20hypertension%20on%20risk%20of%20subsequent%20cardiovascular%20comorbidities%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%20Moreno%22%2C%22lastName%22%3A%22Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22B%5Cu00e4chle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margit%22%2C%22lastName%22%3A%22Heier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.annepidem.2022.07.012%22%2C%22ISSN%22%3A%2210472797%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1047279722001557%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A48%3A34Z%22%7D%7D%2C%7B%22key%22%3A%22ETJRJY8G%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kart%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKart%20T%2C%20Fischer%20M%2C%20Winzeck%20S%2C%20et%20al.%20Automated%20imaging-based%20abdominal%20organ%20segmentation%20and%20quality%20control%20in%2020%2C000%20participants%20of%20the%20UK%20Biobank%20and%20German%20National%20Cohort%20Studies.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202022%3B12%281%29%3A18733.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-022-23632-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-022-23632-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Automated%20imaging-based%20abdominal%20organ%20segmentation%20and%20quality%20control%20in%2020%2C000%20participants%20of%20the%20UK%20Biobank%20and%20German%20National%20Cohort%20Studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Turkay%22%2C%22lastName%22%3A%22Kart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Winzeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Glocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenjia%22%2C%22lastName%22%3A%22Bai%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Friedrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kr%5Cu00f6ncke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Mayer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benedikt%20M.%22%2C%22lastName%22%3A%22Schaarschmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lale%22%2C%22lastName%22%3A%22Umutle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%22%2C%22lastName%22%3A%22Sch%5Cu00f6lkopf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rueckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Large%20epidemiological%20studies%20such%20as%20the%20UK%20Biobank%20%28UKBB%29%20or%20German%20National%20Cohort%20%28NAKO%29%20provide%20unprecedented%20health-related%20data%20of%20the%20general%20population%20aiming%20to%20better%20understand%20determinants%20of%20health%20and%20disease.%20As%20part%20of%20these%20studies%2C%20Magnetic%20Resonance%20Imaging%20%28MRI%29%20is%20performed%20in%20a%20subset%20of%20participants%20allowing%20for%20phenotypical%20and%20functional%20characterization%20of%20different%20organ%20systems.%20Due%20to%20the%20large%20amount%20of%20imaging%20data%2C%20automated%20image%20analysis%20is%20required%2C%20which%20can%20be%20performed%20using%20deep%20learning%20methods%2C%20e.%20g.%20for%20automated%20organ%20segmentation.%20In%20this%20paper%20we%20describe%20a%20computational%20pipeline%20for%20automated%20segmentation%20of%20abdominal%20organs%20on%20MRI%20data%20from%2020%2C000%20participants%20of%20UKBB%20and%20NAKO%20and%20provide%20results%20of%20the%20quality%20control%20process.%20We%20found%20that%20approx.%2090%25%20of%20data%20sets%20showed%20no%20relevant%20segmentation%20errors%20while%20relevant%20errors%20occurred%20in%20a%20varying%20proportion%20of%20data%20sets%20depending%20on%20the%20organ%20of%20interest.%20Image-derived%20features%20based%20on%20automated%20organ%20segmentations%20showed%20relevant%20deviations%20of%20varying%20degree%20in%20the%20presence%20of%20segmentation%20errors.%20These%20results%20show%20that%20large-scale%2C%20deep%20learning-based%20abdominal%20organ%20segmentation%20on%20MRI%20data%20is%20feasible%20with%20overall%20high%20accuracy%2C%20but%20visual%20quality%20control%20remains%20an%20important%20step%20ensuring%20the%20validity%20of%20down-stream%20analyses%20in%20large%20epidemiological%20imaging%20studies.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-022-23632-9%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-022-23632-9%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A45%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22R9YDFPP7%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hassenstein%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHassenstein%20M%2C%20Janzen%20I%2C%20Krause%20G%2C%20et%20al.%20Seroepidemiology%20of%20Borrelia%20burgdorferi%20s.l.%20among%20German%20National%20Cohort%20%28NAKO%29%20Participants%2C%20Hanover.%20%3Ci%3EMicroorganisms%3C%5C%2Fi%3E.%202022%3B10%2811%29%3A2286.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10112286%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fmicroorganisms10112286%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Seroepidemiology%20of%20Borrelia%20burgdorferi%20s.l.%20among%20German%20National%20Cohort%20%28NAKO%29%20Participants%2C%20Hanover%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irina%22%2C%22lastName%22%3A%22Janzen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuela%22%2C%22lastName%22%3A%22Harries%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Melhorn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Kerrinnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%5D%2C%22abstractNote%22%3A%22Lyme%20borreliosis%20is%20the%20leading%20tick-related%20illness%20in%20Europe%2C%20caused%20by%20Borrelia%20Burgdorferi%20s.l.%20Lower%20Saxony%2C%20Germany%2C%20including%20its%20capital%2C%20Hanover%2C%20has%20a%20higher%20proportion%20of%20infected%20ticks%20than%20central%20European%20countries%2C%20justifying%20a%20research%20focus%20on%20the%20potential%20human%20consequences.%20The%20current%20knowledge%20gap%20on%20human%20incident%20infections%2C%20particularly%20in%20Western%20Germany%2C%20demands%20serological%20insights%2C%20especially%20regarding%20a%20potentially%20changing%20climate-related%20tick%20abundance%20and%20activity.%20We%20determined%20the%20immunoglobulin%20G%20%28IgG%29%20and%20immunoglobulin%20M%20%28IgM%29%20serostatuses%20for%208009%20German%20National%20Cohort%20%28NAKO%29%20participants%20from%20Hanover%2C%20examined%20in%202014%5Cu20132018.%20We%20used%20an%20enzyme-linked%20immunosorbent%20assay%20%28ELISA%29%20as%20the%20screening%20and%20a%20line%20immunoblot%20as%20confirmation%20for%20the%20Borrelia%20Burgdorferi%20s.l.%20antibodies.%20We%20weighted%20the%20seropositivity%20proportions%20to%20estimate%20general%20population%20seropositivity%20and%20estimated%20the%20force%20of%20infection%20%28FOI%29.%20Using%20logistic%20regression%2C%20we%20investigated%20risk%20factors%20for%20seropositivity.%20Seropositivity%20was%203.0%25%20%28IgG%29%20and%200.9%25%20%28IgM%29.%20The%20FOI%20varied%20with%20age%2C%20sharply%20increasing%20in%20participants%20aged%20%5Cu226540%20years.%20We%20confirmed%20advancing%20age%20and%20male%20sex%20as%20risk%20factors.%20We%20reported%20reduced%20odds%20for%20seropositivity%20with%20increasing%20body%20mass%20index%20and%20depressive%20symptomatology%2C%20respectively%2C%20pointing%20to%20an%20impact%20of%20lifestyle-related%20behaviors.%20The%20local%20proportion%20of%20seropositive%20individuals%20is%20comparable%20to%20previous%20estimates%20for%20northern%20Germany%2C%20indicating%20a%20steady%20seroprevalence.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fmicroorganisms10112286%22%2C%22ISSN%22%3A%222076-2607%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2076-2607%5C%2F10%5C%2F11%5C%2F2286%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A28%3A29Z%22%7D%7D%2C%7B%22key%22%3A%229TXQDLN9%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Moreno%20Vel%5Cu00e1squez%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMoreno%20Vel%26%23xE1%3Bsquez%20I%2C%20Jaeschke%20L%2C%20Steinbrecher%20A%2C%20et%20al.%20Association%20of%20general%20and%20abdominal%20adiposity%20with%20postural%20changes%20in%20systolic%20blood%20pressure%3A%20results%20from%20the%20NAKO%20pretest%20and%20MetScan%20studies.%20%3Ci%3EHypertens%20Res%3C%5C%2Fi%3E.%202022%3B45%2812%29%3A1964-1976.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41440-022-01029-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41440-022-01029-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Association%20of%20general%20and%20abdominal%20adiposity%20with%20postural%20changes%20in%20systolic%20blood%20pressure%3A%20results%20from%20the%20NAKO%20pretest%20and%20MetScan%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilais%22%2C%22lastName%22%3A%22Moreno%20Vel%5Cu00e1squez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Steinbrecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiner%22%2C%22lastName%22%3A%22Boeing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Janke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20association%20between%20anthropometric%20measurements%20and%20postural%20changes%20in%20systolic%20blood%20pressure%20%28SBP%29%20has%20not%20been%20frequently%20reported.%20This%20study%20aimed%20to%20investigate%20the%20association%20of%20body%20mass%20index%20%28BMI%29%20and%20waist%20circumference%20%28WC%29%20with%20postural%20changes%20in%20SBP%20in%20two%20German%20cross-sectional%20studies.%20Data%20were%20derived%20from%20506%20participants%20of%20the%20population-based%20German%20National%20Cohort%20%28NAKO%29%20pretest%20and%20from%20511%20participants%20of%20the%20convenience%20sample-based%20MetScan%20studies.%20Linear%20regression%20models%20were%20used%20to%20estimate%20the%20association%20between%20BMI%20and%20WC%20with%20the%20difference%20between%20standing%20and%20sitting%20SBP%20%28dSBP%29.%20Odds%20ratios%20%28ORs%29%20for%20an%20increase%20%28dSBP%5Cu2009%3E%5Cu200910%5Cu2009mmHg%29%20or%20decrease%20%28dSBP%5Cu2009%5Cu2264%5Cu2009%5Cu221210%5Cu2009mmHg%29%20in%20dSBP%20were%20calculated%20using%20logistic%20regression.%20The%20results%20were%20pooled%20by%20meta-analysis%20using%20an%20inverse%20variance%20model.%20In%20pooled%20analysis%2C%20a%205%5Cu2009kg%5C%2Fm%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20higher%20BMI%20was%20associated%20with%20a%201.46%5Cu2009mmHg%20%2895%25%20confidence%20interval%20%28CI%29%200.98%5Cu20131.94%29%20higher%20dSBP%2C%20while%20a%205%5Cu2009cm%20higher%20WC%20was%20associated%20with%20a%200.51%5Cu2009mmHg%20%2895%25%20CI%200.32%5Cu20130.69%29%20higher%20dSBP.%20BMI%20or%20WC%20were%20associated%20with%20a%20higher%20odds%20of%20an%20increase%20in%20dSBP%20%28adjusted%20OR%2C%201.71%3B%2095%25%20CI%201.36%5Cu20132.14%20per%205%5Cu2009kg%5C%2Fm%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20higher%20BMI%20and%201.22%3B%2095%25%20CI%201.05%5Cu20131.40%20per%205%5Cu2009cm%20higher%20WC%29%20but%20with%20a%20reduced%20odds%20of%20a%20decline%20in%20dSBP%20%28adjusted%20OR%2C%200.67%3B%2095%25%20CI%200.44%5Cu20131.00%20per%205%5Cu2009kg%5C%2Fm%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20higher%20BMI%20and%200.84%3B%2095%25%20CI%200.72%5Cu20130.99%20per%205%5Cu2009cm%20higher%20WC%29.%20The%20associations%20between%20WC%20and%20dSBP%20were%20no%20longer%20statistically%20significant%20after%20BMI%20adjustments.%5Cu00a0In%20conclusion%2C%20higher%20BMI%20and%20higher%20WC%20were%20associated%20with%20higher%20postural%20increases%20in%20SBP%3B%20however%2C%20WC%20was%20not%20related%20to%20postural%20changes%20in%20SBP%20once%20adjusted%20for%20BMI.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41440-022-01029-5%22%2C%22ISSN%22%3A%220916-9636%2C%201348-4214%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41440-022-01029-5%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-31T14%3A28%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22EPJTCHDC%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Peters%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EPeters%20A%2C%20German%20National%20Cohort%20%28NAKO%29%20Consortium%2C%20Peters%20A%2C%20et%20al.%20Framework%20and%20baseline%20examination%20of%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EEur%20J%20Epidemiol%3C%5C%2Fi%3E.%202022%3B37%2810%29%3A1107-1124.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10654-022-00890-5%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10654-022-00890-5%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Framework%20and%20baseline%20examination%20of%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22German%20National%20Cohort%20%28NAKO%29%20Consortium%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22G%5Cu00f6ttlicher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maren%22%2C%22lastName%22%3A%22Albrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Till%22%2C%22lastName%22%3A%22B%5Cu00e4rnighausen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achim%22%2C%22lastName%22%3A%22Beule%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiner%22%2C%22lastName%22%3A%22Boeing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Bohnert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22Braun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22B%5Cu00fclow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22D%5Cu00f6rr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margit%22%2C%22lastName%22%3A%22Ecker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guido%22%2C%22lastName%22%3A%22Giani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus-Peter%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Haerting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Haug%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%20M.%22%2C%22lastName%22%3A%22Heid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margit%22%2C%22lastName%22%3A%22Heier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Heinemeyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Hendel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochen%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heike%22%2C%22lastName%22%3A%22H%5Cu00f6lling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22H%5Cu00f6rlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Karrasch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadja%22%2C%22lastName%22%3A%22Kartschmit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bianca%22%2C%22lastName%22%3A%22Klee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Birgit%22%2C%22lastName%22%3A%22Kl%5Cu00fcppelholz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Kofink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22K%5Cu00f6ttgen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Kraft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lisa%22%2C%22lastName%22%3A%22Kretz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22K%5Cu00fchnisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna-Therese%22%2C%22lastName%22%3A%22Lehnich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anke%22%2C%22lastName%22%3A%22Macdonald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%20H.%22%2C%22lastName%22%3A%22Maier-Hein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Mangold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juliane%22%2C%22lastName%22%3A%22Melzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bj%5Cu00f6rn%22%2C%22lastName%22%3A%22Mergarten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Moebus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Mueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Nauck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thoralf%22%2C%22lastName%22%3A%22Niendorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantin%22%2C%22lastName%22%3A%22Nikolaou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Ostrzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leo%22%2C%22lastName%22%3A%22Panreck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Pigeot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Pschibul-Thamm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Rathmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achim%22%2C%22lastName%22%3A%22Reineke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Roloff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rujescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rupf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Sander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Schirmacher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Georg%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Sch%5Cu00f6ne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Holger%22%2C%22lastName%22%3A%22Schulz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Schweig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%20M.%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Selder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Six-Merker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Sowade%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Stegle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunthard%22%2C%22lastName%22%3A%22St%5Cu00fcbs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enno%22%2C%22lastName%22%3A%22Swart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henning%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inke%22%2C%22lastName%22%3A%22Thiele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marius%22%2C%22lastName%22%3A%22Ueffing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Werner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.-Erich%22%2C%22lastName%22%3A%22Wichmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Wolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Wolff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Zinkhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Zschocke%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20%28NAKO%29%20is%20a%20multidisciplinary%2C%20population-based%20prospective%20cohort%20study%20that%20aims%20to%20investigate%20the%20causes%20of%20widespread%20diseases%2C%20identify%20risk%20factors%20and%20improve%20early%20detection%20and%20prevention%20of%20disease.%20Specifically%2C%20NAKO%20is%20designed%20to%20identify%20novel%20and%20better%20characterize%20established%20risk%20and%20protection%20factors%20for%20the%20development%20of%20cardiovascular%20diseases%2C%20cancer%2C%20diabetes%2C%20neurodegenerative%20and%20psychiatric%20diseases%2C%20musculoskeletal%20diseases%2C%20respiratory%20and%20infectious%20diseases%20in%20a%20random%20sample%20of%20the%20general%20population.%20Between%202014%20and%202019%2C%20a%20total%20of%20205%2C415%20men%20and%20women%20aged%2019%5Cu201374%5Cu00a0years%20were%20recruited%20and%20examined%20in%2018%20study%20centres%20in%20Germany.%20The%20baseline%20assessment%20included%20a%20face-to-face%20interview%2C%20self-administered%20questionnaires%20and%20a%20wide%20range%20of%20biomedical%20examinations.%20Biomaterials%20were%20collected%20from%20all%20participants%20including%20serum%2C%20EDTA%20plasma%2C%20buffy%20coats%2C%20RNA%20and%20erythrocytes%2C%20urine%2C%20saliva%2C%20nasal%20swabs%20and%20stool.%20In%2056%2C971%20participants%2C%20an%20intensified%20examination%20programme%20was%20implemented.%20Whole-body%203T%20magnetic%20resonance%20imaging%20was%20performed%20in%2030%2C861%20participants%20on%20dedicated%20scanners.%20NAKO%20collects%20follow-up%20information%20on%20incident%20diseases%20through%20a%20combination%20of%20active%20follow-up%20using%20self-report%20via%20written%20questionnaires%20at%202%5Cu20133%5Cu00a0year%20intervals%20and%20passive%20follow-up%20via%20record%20linkages.%20All%20study%20participants%20are%20invited%20for%20re-examinations%20at%20the%20study%20centres%20in%204%5Cu20135%5Cu00a0year%20intervals.%20Thereby%2C%20longitudinal%20information%20on%20changes%20in%20risk%20factor%20profiles%20and%20in%20vascular%2C%20cardiac%2C%20metabolic%2C%20neurocognitive%2C%20pulmonary%20and%20sensory%20function%20is%20collected.%20NAKO%20is%20a%20major%20resource%20for%20population-based%20epidemiology%20to%20identify%20new%20and%20tailored%20strategies%20for%20early%20detection%2C%20prediction%2C%20prevention%20and%20treatment%20of%20major%20diseases%20for%20the%20next%2030%5Cu00a0years.%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10654-022-00890-5%22%2C%22ISSN%22%3A%220393-2990%2C%201573-7284%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs10654-022-00890-5%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A29%3A14Z%22%7D%7D%2C%7B%22key%22%3A%2253A2RHNQ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dragano%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EDragano%20N%2C%20Reuter%20M%2C%20Berger%20K.%20Increase%20in%20mental%20disorders%20during%20the%20COVID-19%20pandemic%26%23x2014%3Bthe%20role%20of%20occupational%20and%20financial%20strains.%20An%20analysis%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20Study.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202022.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2022.0133%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2022.0133%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Increase%20in%20mental%20disorders%20during%20the%20COVID-19%20pandemic%5Cu2014the%20role%20of%20occupational%20and%20financial%20strains.%20An%20analysis%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2022.0133%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.m2022.0133%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A07%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22MNBLMBPT%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Westerman%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWesterman%20R.%20NAKO%20Gesundheitsstudie%20-%20Eine%20erste%20Bilanz%20-%20Eine%20Langzeituntersuchung%20mit%20gro%26%23xDF%3Bem%20Ziel.%20%3Ci%3EBev%26%23xF6%3Blkerungsforschung%3C%5C%2Fi%3E.%202022%3B43%284%29%3A3-7.%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.bib.bund.de%5C%2FPublikation%5C%2F2022%5C%2Fpdf%5C%2FBevoelkerungsforschung-Aktuell-4-2022.pdf%3F__blob%3DpublicationFile%26v%3D3%27%3Ehttps%3A%5C%2F%5C%2Fwww.bib.bund.de%5C%2FPublikation%5C%2F2022%5C%2Fpdf%5C%2FBevoelkerungsforschung-Aktuell-4-2022.pdf%3F__blob%3DpublicationFile%26v%3D3%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22NAKO%20Gesundheitsstudie%20-%20Eine%20erste%20Bilanz%20-%20Eine%20Langzeituntersuchung%20mit%20gro%5Cu00dfem%20Ziel%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronny%22%2C%22lastName%22%3A%22Westerman%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.bib.bund.de%5C%2FPublikation%5C%2F2022%5C%2Fpdf%5C%2FBevoelkerungsforschung-Aktuell-4-2022.pdf%3F__blob%3DpublicationFile%26v%3D3%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-18T11%3A19%3A54Z%22%7D%7D%2C%7B%22key%22%3A%222MSLR9C6%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Heise%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHeise%20JK%2C%20Dey%20R%2C%20Emmerich%20M%2C%20et%20al.%20Putting%20digital%20epidemiology%20into%20practice%3A%20PIA-%20Prospective%20Monitoring%20and%20Management%20Application.%20%3Ci%3EInformatics%20in%20Medicine%20Unlocked%3C%5C%2Fi%3E.%202022%3B30%3A100931.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.imu.2022.100931%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.imu.2022.100931%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Putting%20digital%20epidemiology%20into%20practice%3A%20PIA-%20Prospective%20Monitoring%20and%20Management%20Application%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jana-K.%22%2C%22lastName%22%3A%22Heise%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Dey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcelo%22%2C%22lastName%22%3A%22Emmerich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabrina%22%2C%22lastName%22%3A%22Sistig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.imu.2022.100931%22%2C%22ISSN%22%3A%2223529148%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS235291482200079X%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-18T08%3A32%3A44Z%22%7D%7D%2C%7B%22key%22%3A%226U7PJYC9%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Formazin%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFormazin%20M%2C%20Liebers%20F%2C%20Reuter%20M%2C%20Rig%26%23xF3%3B%20M%2C%20Dragano%20N%2C%20Latza%20U.%20Berufsbezogenes%20Risiko%20einer%20SARS-CoV-2-Infektion%20in%20der%20ersten%20Welle%20der%20COVID-19-Pandemie%3A%20Ergebnisse%20auf%20Basis%20der%20NAKO%20Gesundheitsstudie.%202022.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21934%5C%2FBAUA%3ABERICHTKOMPAKT20220711%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.21934%5C%2FBAUA%3ABERICHTKOMPAKT20220711%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Berufsbezogenes%20Risiko%20einer%20SARS-CoV-2-Infektion%20in%20der%20ersten%20Welle%20der%20COVID-19-Pandemie%3A%20Ergebnisse%20auf%20Basis%20der%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maren%22%2C%22lastName%22%3A%22Formazin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Falk%22%2C%22lastName%22%3A%22Liebers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariann%22%2C%22lastName%22%3A%22Rig%5Cu00f3%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ute%22%2C%22lastName%22%3A%22Latza%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222022%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.21934%5C%2FBAUA%3ABERICHTKOMPAKT20220711%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.baua.de%5C%2FDE%5C%2FAngebote%5C%2FPublikationen%5C%2FBericht-kompakt%5C%2FF2515.html%3Fpk_campaign%3DDOI%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-17T14%3A30%3A35Z%22%7D%7D%5D%7D
1.
Reuter M, Rigó M, Formazin M, et al. Authors’ response: Occupation and SARS-CoV-2 infection risk among workers during the first pandemic wave in Germany: potential for bias. Scand J Work Environ Health. 2022;48(7):588-590. http://doi.org/10.5271/sjweh.4061
1.
Rickmann AM, Senapati J, Kovalenko O, Peters A, Bamberg F, Wachinger C. AbdomenNet: deep neural network for abdominal organ segmentation in epidemiologic imaging studies. BMC Med Imaging. 2022;22(1):168. http://doi.org/10.1186/s12880-022-00893-4
1.
Streckenbach F, Leifert G, Beyer T, et al. Application of a Deep Learning Approach to Analyze Large-Scale MRI Data of the Spine. Healthcare. 2022;10(11):2132. http://doi.org/10.3390/healthcare10112132
1.
Tanoey J, Baechle C, Brenner H, et al. Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort. IJERPH. 2022;19(17):10880. http://doi.org/10.3390/ijerph191710880
1.
Wienbergen H, Boakye D, Günther K, et al. Lifestyle and metabolic risk factors in patients with early-onset myocardial infarction: a case-control study. European Journal of Preventive Cardiology. 2022;29(16):2076-2087. http://doi.org/10.1093/eurjpc/zwac132
1.
Hahn T, Ernsting J, Winter NR, et al. An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling. Sci Adv. 2022;8(1):eabg9471. http://doi.org/10.1126/sciadv.abg9471
1.
Kuss O, Becher H, Wienke A, et al. Statistical Analysis in the German National Cohort (NAKO) – Specific Aspects and General Recommendations. Eur J Epidemiol. 2022;37(4):429-436. http://doi.org/10.1007/s10654-022-00880-7
1.
Schuppert C, Krüchten RV, Hirsch JG, et al. Whole-Body Magnetic Resonance Imaging in the Large Population-Based German National Cohort Study: Predictive Capability of Automated Image Quality Assessment for Protocol Repetitions. Invest Radiol. 2022;57(7):478-487. http://doi.org/10.1097/RLI.0000000000000861
1.
Reuter M, Rigó M, Formazin M, et al. Occupation and SARS-CoV-2 infection risk among 108 960 workers during the first pandemic wave in Germany. Scand J Work Environ Health. 2022;48(6):446-456. http://doi.org/10.5271/sjweh.4037
1.
Jaeschke L, Becher M, Velásquez IM, et al. The bias from heaping on risk estimation: effect of age at diagnosis of hypertension on risk of subsequent cardiovascular comorbidities. Annals of Epidemiology. 2022;74:84-96. http://doi.org/10.1016/j.annepidem.2022.07.012
1.
Kart T, Fischer M, Winzeck S, et al. Automated imaging-based abdominal organ segmentation and quality control in 20,000 participants of the UK Biobank and German National Cohort Studies. Sci Rep. 2022;12(1):18733. http://doi.org/10.1038/s41598-022-23632-9
1.
Hassenstein M, Janzen I, Krause G, et al. Seroepidemiology of Borrelia burgdorferi s.l. among German National Cohort (NAKO) Participants, Hanover. Microorganisms. 2022;10(11):2286. http://doi.org/10.3390/microorganisms10112286
1.
Moreno Velásquez I, Jaeschke L, Steinbrecher A, et al. Association of general and abdominal adiposity with postural changes in systolic blood pressure: results from the NAKO pretest and MetScan studies. Hypertens Res. 2022;45(12):1964-1976. http://doi.org/10.1038/s41440-022-01029-5
1.
Peters A, German National Cohort (NAKO) Consortium, Peters A, et al. Framework and baseline examination of the German National Cohort (NAKO). Eur J Epidemiol. 2022;37(10):1107-1124. http://doi.org/10.1007/s10654-022-00890-5
1.
Dragano N, Reuter M, Berger K. Increase in mental disorders during the COVID-19 pandemic—the role of occupational and financial strains. An analysis of the German National Cohort (NAKO) Study. Deutsches Ärzteblatt international. 2022. http://doi.org/10.3238/arztebl.m2022.0133
1.
Westerman R. NAKO Gesundheitsstudie - Eine erste Bilanz - Eine Langzeituntersuchung mit großem Ziel. Bevölkerungsforschung. 2022;43(4):3-7. https://www.bib.bund.de/Publikation/2022/pdf/Bevoelkerungsforschung-Aktuell-4-2022.pdf?__blob=publicationFile&v=3.
1.
Heise JK, Dey R, Emmerich M, et al. Putting digital epidemiology into practice: PIA- Prospective Monitoring and Management Application. Informatics in Medicine Unlocked. 2022;30:100931. http://doi.org/10.1016/j.imu.2022.100931
1.
Formazin M, Liebers F, Reuter M, Rigó M, Dragano N, Latza U. Berufsbezogenes Risiko einer SARS-CoV-2-Infektion in der ersten Welle der COVID-19-Pandemie: Ergebnisse auf Basis der NAKO Gesundheitsstudie. 2022. http://doi.org/10.21934/BAUA:BERICHTKOMPAKT20220711
5565830
2021
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22J8QW8J8R%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hahn%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHahn%20T%2C%20Fisch%20L%2C%20Ernsting%20J%2C%20et%20al.%20From%20%26%23x2018%3Bloose%20fitting%26%23x2019%3B%20to%20high-performance%2C%20uncertainty-aware%20brain-age%20modelling.%20%3Ci%3EBrain%3C%5C%2Fi%3E.%202021%3B144%283%29%3Ae31-e31.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaa454%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fbrain%5C%2Fawaa454%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22From%20%5Cu2018loose%20fitting%5Cu2019%20to%20high-performance%2C%20uncertainty-aware%20brain-age%20modelling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Hahn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lukas%22%2C%22lastName%22%3A%22Fisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Ernsting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nils%20R%22%2C%22lastName%22%3A%22Winter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramona%22%2C%22lastName%22%3A%22Leenings%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelvin%22%2C%22lastName%22%3A%22Sarink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Emden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tilo%22%2C%22lastName%22%3A%22Kircher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Dannlowski%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1093%5C%2Fbrain%5C%2Fawaa454%22%2C%22ISSN%22%3A%220006-8950%2C%201460-2156%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fbrain%5C%2Farticle%5C%2F144%5C%2F3%5C%2Fe31%5C%2F6214475%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22UBQ882QD%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hepp%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHepp%20T%2C%20Blum%20D%2C%20Armanious%20K%2C%20et%20al.%20Uncertainty%20estimation%20and%20explainability%20in%20deep%20learning-based%20age%20estimation%20of%20the%20human%20brain%3A%20Results%20from%20the%20German%20National%20Cohort%20MRI%20study.%20%3Ci%3EComputerized%20Medical%20Imaging%20and%20Graphics%3C%5C%2Fi%3E.%202021%3B92%3A101967.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.compmedimag.2021.101967%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.compmedimag.2021.101967%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Uncertainty%20estimation%20and%20explainability%20in%20deep%20learning-based%20age%20estimation%20of%20the%20human%20brain%3A%20Results%20from%20the%20German%20National%20Cohort%20MRI%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Hepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Blum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karim%22%2C%22lastName%22%3A%22Armanious%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernhard%22%2C%22lastName%22%3A%22Sch%5Cu00f6lkopf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Darko%22%2C%22lastName%22%3A%22Stern%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.compmedimag.2021.101967%22%2C%22ISSN%22%3A%2208956111%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0895611121001166%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A20Z%22%7D%7D%2C%7B%22key%22%3A%22PUDZRDA2%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kart%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKart%20T%2C%20Fischer%20M%2C%20K%26%23xFC%3Bstner%20T%2C%20et%20al.%20Deep%20Learning%26%23x2010%3BBased%20Automated%20Abdominal%20Organ%20Segmentation%20in%20the%20UK%20Biobank%20and%20German%20National%20Cohort%20Magnetic%20Resonance%20Imaging%20Studies.%20%3Ci%3EInvest%20Radiol%3C%5C%2Fi%3E.%202021%3B56%286%29%3A401-408.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000755%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRLI.0000000000000755%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Deep%20Learning%5Cu2010Based%20Automated%20Abdominal%20Organ%20Segmentation%20in%20the%20UK%20Biobank%20and%20German%20National%20Cohort%20Magnetic%20Resonance%20Imaging%20Studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Turkay%22%2C%22lastName%22%3A%22Kart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Hepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Winzeck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Glocker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Rueckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20aims%20of%20this%20study%20were%20to%20train%20and%20evaluate%20deep%20learning%20models%20for%20automated%20segmentation%20of%20abdominal%20organs%20in%20whole-body%20magnetic%20resonance%20%28MR%29%20images%20from%20the%20UK%20Biobank%20%28UKBB%29%20and%20German%20National%20Cohort%20%28GNC%29%20MR%20imaging%20studies%20and%20to%20make%20these%20models%20available%20to%20the%20scientific%20community%20for%20analysis%20of%20these%20data%20sets.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%20total%20of%20200%20T1-weighted%20MR%20image%20data%20sets%20of%20healthy%20volunteers%20each%20from%20UKBB%20and%20GNC%20%28400%20data%20sets%20in%20total%29%20were%20available%20in%20this%20study.%20Liver%2C%20spleen%2C%20left%20and%20right%20kidney%2C%20and%20pancreas%20were%20segmented%20manually%20on%20all%20400%20data%20sets%2C%20providing%20labeled%20ground%20truth%20data%20for%20training%20of%20a%20previously%20described%20U-Net-based%20deep%20learning%20framework%20for%20automated%20medical%20image%20segmentation%20%28nnU-Net%29.%20The%20trained%20models%20were%20tested%20on%20all%20data%20sets%20using%20a%204-fold%20cross-validation%20scheme.%20Qualitative%20analysis%20of%20automated%20segmentation%20results%20was%20performed%20visually%3B%20performance%20metrics%20between%20automated%20and%20manual%20segmentation%20results%20were%20computed%20for%20quantitative%20analysis.%20In%20addition%2C%20interobserver%20segmentation%20variability%20between%202%20human%20readers%20was%20assessed%20on%20a%20subset%20of%20the%20data.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Automated%20abdominal%20organ%20segmentation%20was%20performed%20with%20high%20qualitative%20and%20quantitative%20accuracy%20on%20UKBB%20and%20GNC%20data.%20In%20more%20than%2090%25%20of%20data%20sets%2C%20no%20or%20only%20minor%20visually%20detectable%20qualitative%20segmentation%20errors%20occurred.%20Mean%20Dice%20scores%20of%20automated%20segmentations%20compared%20with%20manual%20reference%20segmentations%20were%20well%20higher%20than%200.9%20for%20the%20liver%2C%20spleen%2C%20and%20kidneys%20on%20UKBB%20and%20GNC%20data%20and%20around%200.82%20and%200.89%20for%20the%20pancreas%20on%20UKBB%20and%20GNC%20data%2C%20respectively.%20Mean%20average%20symmetric%20surface%20distance%20was%20between%200.3%20and%201.5%20mm%20for%20the%20liver%2C%20spleen%2C%20and%20kidneys%20and%20between%202%20and%202.2%20mm%20for%20pancreas%20segmentation.%20The%20quantitative%20accuracy%20of%20automated%20segmentation%20was%20comparable%20with%20the%20agreement%20between%202%20human%20readers%20for%20all%20organs%20on%20UKBB%20and%20GNC%20data.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Automated%20segmentation%20of%20abdominal%20organs%20is%20possible%20with%20high%20qualitative%20and%20quantitative%20accuracy%20on%20whole-body%20MR%20imaging%20data%20acquired%20as%20part%20of%20UKBB%20and%20GNC.%20The%20results%20obtained%20and%20deep%20learning%20models%20trained%20in%20this%20study%20can%20be%20used%20as%20a%20foundation%20for%20automated%20analysis%20of%20thousands%20of%20MR%20data%20sets%20of%20UKBB%20and%20GNC%20and%20thus%20contribute%20to%20tackling%20topical%20and%20original%20scientific%20questions.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FRLI.0000000000000755%22%2C%22ISSN%22%3A%221536-0210%2C%200020-9996%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2F10.1097%5C%2FRLI.0000000000000755%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A14Z%22%7D%7D%2C%7B%22key%22%3A%22TZ5GPWSP%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Krist%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKrist%20L%2C%20Bedir%20A%2C%20Fricke%20J%2C%20Kluttig%20A%2C%20Mikolajczyk%20R.%20The%20effect%20of%20home%20visits%20as%20an%20additional%20recruitment%20step%20on%20the%20composition%20of%20the%20final%20sample%3A%20a%20cross-sectional%20analysis%20in%20two%20study%20centers%20of%20the%20German%20National%20Cohort%20%28NAKO%29.%20%3Ci%3EBMC%20Med%20Res%20Methodol%3C%5C%2Fi%3E.%202021%3B21%281%29%3A176.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12874-021-01357-z%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12874-021-01357-z%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20effect%20of%20home%20visits%20as%20an%20additional%20recruitment%20step%20on%20the%20composition%20of%20the%20final%20sample%3A%20a%20cross-sectional%20analysis%20in%20two%20study%20centers%20of%20the%20German%20National%20Cohort%20%28NAKO%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahmed%22%2C%22lastName%22%3A%22Bedir%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Participation%20in%20epidemiologic%20studies%20has%20been%20declining%20over%20the%20last%20decades.%20In%20addition%20to%20postal%20invitations%20and%20phone%20calls%2C%20home%20visits%20can%20be%20conducted%20to%20increase%20participation.%20The%20aim%20of%20this%20study%20was%20therefore%20to%20evaluate%20the%20effects%20of%20home%20visits%20in%20terms%20of%20response%20increase%20and%20composition%20of%20the%20additionally%20recruited%20and%20final%20sample.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20framework%20of%20the%20German%20National%20Cohort%20%28NAKO%29%20recruitment%20process%2C%20two%20of%2018%20study%20centers%2C%20Halle%20%28Saale%29%20and%20Berlin-Center%2C%20performed%20home%20visits%20as%20additional%20recruitment%20step%20after%20postal%20invitation%20and%20reminders.%20Response%20increase%20was%20calculated%20and%20differences%20between%20participants%20recruited%20via%20home%20visits%20and%20standard%20recruitment%20were%20examined.%20Proportions%20are%20presented%20as%20percentages%20with%2095%25-confidence%20intervals.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20general%20population%20in%20Halle%2C%2021.3-22.8%25%20participated%20after%20postal%20invitation%20and%20two%20reminders%20in%20the%20five%20assessed%20recruitment%20waves.%20The%20increase%20of%20the%20overall%20response%20was%202.8%20percentage%20points%20%2895%25confidence%20interval%3A%201.9-4.0%29%20for%20home%20visits%20compared%20to%202.4%20percentage%20points%20%2895%25CI%3A%201.7-3.3%29%20for%20alternatively%20sent%20third%20postal%20reminder.%20Participants%20recruited%20via%20home%20visits%20had%20similar%20characteristics%20to%20those%20recruited%20via%20standard%20recruitment.%20Among%20persons%20of%20Turkish%20descent%20in%20Berlin-Center%20site%20of%20the%20NAKO%2C%20home%20visits%20conducted%20by%20native%20speakers%20increased%20the%20participation%20of%20women%2C%20persons%20living%20together%20with%20their%20partner%2C%20were%20born%20in%20Turkey%2C%20had%20lower%20German%20language%20skills%2C%20lower-income%2C%20lower%20education%2C%20were%20more%20often%20smokers%20and%20reported%20more%20often%20diabetes%20and%20depression%20to%20a%20degree%20which%20changed%20overall%20estimates%20for%20this%20subsample.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20As%20an%20additional%20recruitment%20measure%20in%20the%20general%20population%2C%20home%20visits%20increased%20response%20only%20marginally%2C%20and%20the%20through%20home%20visits%20recruited%20participants%20did%20not%20differ%20from%20those%20already%20recruited.%20Among%20persons%20with%20migration%20background%2C%20home%20visits%20by%20a%20native%20speaker%20increased%20participation%20of%20persons%20not%20reached%20by%20the%20standard%20recruitment%2C%20but%20the%20effects%20of%20using%20a%20native%20speaker%20approach%20could%20not%20be%20separated%20from%20the%20effect%20of%20home%20visits.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12874-021-01357-z%22%2C%22ISSN%22%3A%221471-2288%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcmedresmethodol.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12874-021-01357-z%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22YXXILM4Y%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Uekoetter%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EUekoetter%20K%2C%20Ebert%20N%2C%20Stoffels%20A%2C%20Wigmann%20C%2C%20Schikowski%20T.%20Validation%20of%20the%20TeleForm%20scan%20workflow%20in%20the%20GNC%20health%20study%20on%20the%20example%20of%20the%20questionnaire%20on%20physical%20activity.%20%3Ci%3EGMS%20Med%20Inform%20Biom%20Epidemiol%3C%5C%2Fi%3E.%202021%3A17%281%29%3ADoc03.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3205%5C%2FMIBE000217%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3205%5C%2FMIBE000217%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Validation%20of%20the%20TeleForm%20scan%20workflow%20in%20the%20GNC%20health%20study%20on%20the%20example%20of%20the%20questionnaire%20on%20physical%20activity%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katja%22%2C%22lastName%22%3A%22Uekoetter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Stoffels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Wigmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%5D%2C%22abstractNote%22%3A%22Die%20elektronische%20Datenerfassung%20%28EDC%29%20ist%20ein%20wichtiges%20Instrument%20zur%20Digitalisierung%20von%20papierbasierten%20Dokumenten%20wie%20beispielsweise%20Frageb%5Cu00f6gen.%20Ebenso%20ist%20es%20f%5Cu00fcr%20die%20Identifizierung%20von%20Fehlern%20hilfreich%2C%20bevor%20die%20Werte%20endg%5Cu00fcltig%20in%20einer%20Datenbank%20gespeichert%20werden.%20Die%20Datenerfassungssoftware%20TeleForm%20ist%20ein%20Beispiel%20f%5Cu00fcr%20ein%20EDC-System%2C%20das%20zur%20Digitalisierung%20von%20papierbasierten%20Dokumenten%20eingesetzt%20wird.%20TeleForm%20pr%5Cu00fcft%20die%20Daten%20des%20eingescannten%20Dokumentes%20und%20gibt%20Hinweise%20auf%20m%5Cu00f6glicherweise%20fehlerhaft%20gelesene%20Daten.%20In%20der%20NAKO%20Gesundheitsstudie%20wird%20diese%20Software%20unter%20anderem%20zur%20Digitalisierung%20von%20Frageb%5Cu00f6gen%20eingesetzt.%7C%20In%20diesem%20Artikel%20werden%20die%20folgenden%20Fragen%20behandelt%3A%20Ist%20der%20Scan-Workflow%20bezogen%20auf%20die%20Frageb%5Cu00f6gen%20in%20der%20NAKO%20Gesundheitsstudie%20und%20insbesondere%20die%20Datenerfassungssoftware%20TeleForm%20%28mit%20den%20f%5Cu00fcr%20die%20NAKO%20gew%5Cu00e4hlten%20Einstellungen%29%20zuverl%5Cu00e4ssig%3F%20Wieviel%20Verlust%20an%20Datenqualit%5Cu00e4t%20ist%20akzeptabel%2C%20um%20den%20Arbeitsaufwand%20zu%20reduzieren%3F%20Kann%20k%5Cu00fcnstliche%20Intelligenz%20die%20menschliche%20%5Cu00dcberpr%5Cu00fcfung%20ausreichend%20ersetzen%20oder%20wird%20letztere%20auch%20in%20Zukunft%20eine%20unverzichtbare%20Rolle%20im%20Scan-Workflow%20der%20NAKO%20spielen%3F%20Durch%20die%20Beantwortung%20dieser%20Fragen%20sollen%20die%20St%5Cu00e4rken%20und%20Grenzen%20des%20Scan-Workflows%20in%20der%20NAKO%20Gesundheitsstudie%20unter%20Verwendung%20der%20TeleForm-Software%20diskutiert%20werden.%20Die%20aktuelle%20Arbeit%20verwendet%20Daten%2C%20die%20im%20NAKO-Zentrum%20in%20D%5Cu00fcsseldorf%20erhoben%20wurden.%20300%20Frageb%5Cu00f6gen%20zur%20k%5Cu00f6rperlichen%20Aktivit%5Cu00e4t%20wurden%20validiert%20und%20zweimal%20%5Cu00fcberpr%5Cu00fcft%2C%20zum%20einen%20durch%20das%20System%20TeleForm%20und%20zum%20anderen%20durch%20eine%20visuelle%20Kontrolle.%20Die%20Datenerfassungssoftware%20TeleForm%20zeigt%20hohe%20Fehlerquoten%20bei%20der%20Interpretation%20von%20Freitextfeldern%20sowie%20beim%20Lesen%20von%20handgeschriebenen%20Zahlen.%20Insbesondere%20die%20Ziffer%20%5Cu201e0%5Cu201c%20wurde%20am%20h%5Cu00e4ufigsten%20falsch%20interpretiert.%20Um%20Zeit%20zu%20sparen%20und%20damit%20die%20Arbeit%20zu%20erleichtern%2C%20m%5Cu00fcssen%20einige%20Defizite%20behoben%20werden.%20Dies%20kann%20zum%20Beispiel%20durch%20die%20Erweiterung%20der%20Lesebereiche%20sowie%20die%20Verbesserung%20des%20Lesens%20von%20Zahlenwerten%20erzielt%20werden.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3205%5C%2FMIBE000217%22%2C%22ISSN%22%3A%221860-9171%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.egms.de%5C%2Fen%5C%2Fjournals%5C%2Fmibe%5C%2F2021-17%5C%2Fmibe000217.shtml%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-08-01T12%3A58%3A37Z%22%7D%7D%2C%7B%22key%22%3A%224GSACCRZ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Berger%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EBerger%20K%2C%20Riedel-Heller%20S%2C%20Pabst%20A%2C%20et%20al.%20Einsamkeit%20w%26%23xE4%3Bhrend%20der%20ersten%20Welle%20der%20SARS-CoV-2-Pandemie%20%26%23x2013%3B%20Ergebnisse%20der%20NAKO-Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202021%3B64%289%29%3A1157-1164.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-021-03393-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-021-03393-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Einsamkeit%20w%5Cu00e4hrend%20der%20ersten%20Welle%20der%20SARS-CoV-2-Pandemie%20%5Cu2013%20Ergebnisse%20der%20NAKO-Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffi%22%2C%22lastName%22%3A%22Riedel-Heller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Pabst%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Rietschel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Richter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22NAKO-Konsortium%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Hermes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%22%2C%22lastName%22%3A%22Halina%20Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dan%22%2C%22lastName%22%3A%22Rujescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Mit%20Beginn%20der%20SARS-CoV-2-Pandemie%20und%20der%20nachfolgenden%20Ma%5Cu00dfnahmen%20zu%20ihrer%20Eind%5Cu00e4mmung%20im%20Fr%5Cu00fchjahr%202020%20ist%20rasch%20die%20Frage%20nach%20Auswirkungen%20der%20Beschr%5Cu00e4nkung%20sozialer%20Kontakte%20auf%20die%20psychische%20Gesundheit%20der%20Bev%5Cu00f6lkerung%20aufgekommen.%20Einsamkeit%20beschreibt%20eine%20wahrgenommene%20Qualit%5Cu00e4t%20der%20eigenen%20Kontakte%20und%20Beziehungen%20zu%20anderen%20Menschen.%20Zahlreiche%20Studien%20haben%20einen%20Zusammenhang%20von%20Einsamkeit%20mit%20somatischen%20und%20psychischen%20Erkrankungen%20aufgezeigt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Auswertung%20der%20H%5Cu00e4ufigkeit%20von%20Einsamkeit%20und%20ihrer%20Beziehung%20zu%20Angst-%20und%20Depressionssymptomen%20in%20der%20ersten%20Welle%20der%20Pandemie%20im%20Mai%202020.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Zwischen%202014%20und%202019%20hat%20die%20NAKO-Gesundheitsstudie%20205.000%20Personen%20im%20Alter%20zwischen%2020%20und%2069%5Cu00a0Jahren%20in%2018%5Cu00a0Studienzentren%20in%20Deutschland%20rekrutiert%20und%20untersucht.%20Die%20nachfolgende%20Zweituntersuchung%20musste%20aufgrund%20der%20Pandemie%20im%20Fr%5Cu00fchjahr%202020%20unterbrochen%20werden.%20In%20dieser%20Zeit%20wurde%20ein%20COVID-19-bezogener%20Fragebogen%20entwickelt%20und%20an%20alle%20Teilnehmenden%20verschickt.%20Ausgewertet%20wurden%20die%20113.928%20Frageb%5Cu00f6gen%2C%20die%20innerhalb%20der%20ersten%2030%5Cu00a0Tage%20zur%5Cu00fcckgeschickt%20wurden.%20Einsamkeit%20wurde%20mit%20der%203%5Cu2011Item%20UCLA%20Loneliness%20Scale%2C%20Angst%20und%20Depression%20mit%20den%20PHQ-9-%20und%20GAD-7-Skalen%20des%20Patient%20Health%20Questionnaire%20erhoben.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Im%20Mai%202020%20nahmen%20sich%2031%2C7%5Cu202f%25%20der%20NAKO-Teilnehmenden%20als%20einsam%20wahr.%20Frauen%20und%20junge%20Menschen%20waren%20h%5Cu00e4ufiger%20als%20M%5Cu00e4nner%20und%20%5Cu00e4ltere%20Personen%20betroffen.%20Mit%20steigender%20Wahrnehmung%20von%20Einsamkeit%20nahm%20der%20Schweregrad%20von%20Depressions-%20und%20Angstsymptomen%20stetig%20zu.%20Einsame%20Personen%20w%5Cu00e4hrend%20der%20Pandemie%20hatten%20bereits%20zur%20NAKO-Basisuntersuchung%20mehr%20depressive%20und%20Angstsymptome%20angegeben%20als%20NAKO-Teilnehmende%2C%20die%20sich%20in%20der%20Pandemie%20nicht%20einsam%20f%5Cu00fchlten.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Schlussfolgerung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20der%20NAKO-Gesundheitsstudie%20zeigte%20sich%20w%5Cu00e4hrend%20der%20ersten%20Phase%20der%20Pandemie%20eine%20Zunahme%20von%20Einsamkeit%20und%20ihr%20deutlicher%20Zusammenhang%20mit%20schlechterer%2C%20psychischer%20Gesundheit.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Early%20during%20the%20pandemic%20and%20the%20following%20protective%20countermeasures%2C%20an%20interest%20in%20the%20consequences%20of%20the%20enacted%20restriction%20of%20social%20contacts%20for%20the%20mental%20health%20of%20the%20population%20arose.%20Loneliness%20describes%20the%20perceived%20quality%20of%20one%5Cu2019s%20own%20contacts%20and%20relationships%20with%20other%20individuals.%20Several%20prior%20studies%20reported%20associations%20of%20loneliness%20with%20different%20somatic%20and%20psychiatric%20disorders.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Aim%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20analyse%20the%20frequency%20of%20loneliness%20and%20its%20association%20with%20depression%20and%20anxiety%20symptoms%20in%20the%20first%20wave%20of%20the%20pandemic%20in%20Germany%20in%20May%202020.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20%28NAKO%29%20had%20recruited%20and%20examined%20205%2C000%20individuals%20aged%2020%20to%2069%5Cu00a0years%20in%2018%5Cu00a0study%20centres%20across%20Germany%20between%202014%20and%202019.%20The%20follow-up%20examination%20was%20temporarily%20stopped%20due%20to%20the%20pandemic%20between%20March%20and%20July%202020.%20In%20this%20period%20a%5Cu00a0COVID-related%20questionnaire%20was%20developed%20and%20sent%20to%20all%20participants.%20We%20analysed%20the%20first%20113%2C928%20questionnaires%20that%20were%20sent%20back%20within%20four%5Cu00a0weeks%20in%20May%202020.%20Loneliness%20was%20assessed%20with%20the%20three-item%20UCLA%20Loneliness%20Scale%20and%20anxiety%20and%20depression%20symptoms%20were%20collected%20using%20the%20PHQ%5Cu20119%20and%20GAD%5Cu20117%20scales%20from%20the%20Patient%20Health%20Questionnaire.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Among%20the%20NAKO%20participants%2C%2031.7%25%20reported%20to%20be%20lonely%20in%20May%202020.%20Women%20and%20young%20adults%20reported%20more%20loneliness%20than%20men%20and%20older%20adults.%20With%20increasing%20scores%20of%20loneliness%2C%20the%20severity%20of%20depression%20and%20anxiety%20symptoms%20also%20steadily%20increased.%20Individuals%20who%20were%20lonely%20during%20the%20pandemic%20had%20already%20reported%20higher%20PHQ%5Cu20119%20and%20GAD%5Cu20117%20scores%20during%20the%20baseline%20examination%20on%20average%202.5%5Cu00a0years%20earlier%2C%20compared%20to%20those%20who%20did%20not%20feel%20lonely.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Among%20participants%20of%20the%20German%20National%20Cohort%2C%20we%20observed%20an%20increase%20in%20loneliness%20during%20the%20first%20wave%20of%20the%20SARS-CoV%5Cu20112%20pandemic%20in%20spring%202020%20and%20a%5Cu00a0strong%20relationship%20of%20increasing%20loneliness%20with%20decreasing%20mental%20health.%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-021-03393-y%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-021-03393-y%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-01T12%3A53%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22BEQEEPX7%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fischer%20et%20al.%22%2C%22parsedDate%22%3A%222021%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFischer%20M%2C%20Walter%20SS%2C%20Hepp%20T%2C%20et%20al.%20Automated%20Morphometric%20Analysis%20of%20the%20Hip%20Joint%20on%20MRI%20from%20the%20German%20National%20Cohort%20Study.%20%3Ci%3ERadiology%3A%20Artificial%20Intelligence%3C%5C%2Fi%3E.%202021%3B3%285%29%3Ae200213.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Fryai.2021200213%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Fryai.2021200213%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Automated%20Morphometric%20Analysis%20of%20the%20Hip%20Joint%20on%20MRI%20from%20the%20German%20National%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sven%20S.%22%2C%22lastName%22%3A%22Walter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Hepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manuela%22%2C%22lastName%22%3A%22Zimmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mike%22%2C%22lastName%22%3A%22Notohamiprodjo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fritz%22%2C%22lastName%22%3A%22Schick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1148%5C%2Fryai.2021200213%22%2C%22ISSN%22%3A%222638-6100%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fpubs.rsna.org%5C%2Fdoi%5C%2F10.1148%5C%2Fryai.2021200213%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-01T12%3A42%3A09Z%22%7D%7D%5D%7D
1.
Hahn T, Fisch L, Ernsting J, et al. From ‘loose fitting’ to high-performance, uncertainty-aware brain-age modelling. Brain. 2021;144(3):e31-e31. http://doi.org/10.1093/brain/awaa454
1.
Hepp T, Blum D, Armanious K, et al. Uncertainty estimation and explainability in deep learning-based age estimation of the human brain: Results from the German National Cohort MRI study. Computerized Medical Imaging and Graphics. 2021;92:101967. http://doi.org/10.1016/j.compmedimag.2021.101967
1.
Kart T, Fischer M, Küstner T, et al. Deep Learning‐Based Automated Abdominal Organ Segmentation in the UK Biobank and German National Cohort Magnetic Resonance Imaging Studies. Invest Radiol. 2021;56(6):401-408. http://doi.org/10.1097/RLI.0000000000000755
1.
Krist L, Bedir A, Fricke J, Kluttig A, Mikolajczyk R. The effect of home visits as an additional recruitment step on the composition of the final sample: a cross-sectional analysis in two study centers of the German National Cohort (NAKO). BMC Med Res Methodol. 2021;21(1):176. http://doi.org/10.1186/s12874-021-01357-z
1.
Uekoetter K, Ebert N, Stoffels A, Wigmann C, Schikowski T. Validation of the TeleForm scan workflow in the GNC health study on the example of the questionnaire on physical activity. GMS Med Inform Biom Epidemiol. 2021:17(1):Doc03. http://doi.org/10.3205/MIBE000217
1.
Berger K, Riedel-Heller S, Pabst A, et al. Einsamkeit während der ersten Welle der SARS-CoV-2-Pandemie – Ergebnisse der NAKO-Gesundheitsstudie. Bundesgesundheitsbl. 2021;64(9):1157-1164. http://doi.org/10.1007/s00103-021-03393-y
1.
Fischer M, Walter SS, Hepp T, et al. Automated Morphometric Analysis of the Hip Joint on MRI from the German National Cohort Study. Radiology: Artificial Intelligence. 2021;3(5):e200213. http://doi.org/10.1148/ryai.2021200213
5565830
2020
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226ALYNPJH%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Fischer%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EFischer%20B%2C%20Sedlmeier%20AM%2C%20Hartwig%20S%2C%20et%20al.%20Anthropometrische%20Messungen%20in%20der%20NAKO%20Gesundheitsstudie%20%26%23x2013%3B%20mehr%20als%20nur%20Gr%26%23xF6%3B%26%23xDF%3Be%20und%20Gewicht.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A290-300.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03096-w%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03096-w%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Anthropometrische%20Messungen%20in%20der%20NAKO%20Gesundheitsstudie%20%5Cu2013%20mehr%20als%20nur%20Gr%5Cu00f6%5Cu00dfe%20und%20Gewicht%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%20M.%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Saskia%22%2C%22lastName%22%3A%22Hartwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christopher%20L.%22%2C%22lastName%22%3A%22Schlett%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans%22%2C%22lastName%22%3A%22Binder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prudence%20R.%22%2C%22lastName%22%3A%22Carr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Niedermaier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristina%22%2C%22lastName%22%3A%22Norman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jelena%22%2C%22lastName%22%3A%22Stojicic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Tiller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20F.%22%2C%22lastName%22%3A%22Leitzmann%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00dcbergewicht%20und%20Adipositas%20sind%20bedeutende%20Risikofaktoren%20f%5Cu00fcr%20verschiedene%20Erkrankungen.%20Als%20Ma%5Cu00df%20zu%20ihrer%20Bestimmung%20wurde%20in%20fr%5Cu00fcheren%20Studien%20meist%20nur%20der%20Body-Mass-Index%20%28BMI%29%20verwendet.%20Der%20BMI%20ist%20allerdings%20ein%20Marker%2C%20der%20den%20Einfluss%20auf%20das%20Krankheitsrisiko%20nur%20unzureichend%20erfasst.%20In%20gro%5Cu00df%20angelegten%2C%20bev%5Cu00f6lkerungsbasierten%20Studien%20besteht%20daher%20ein%20vordringlicher%20Bedarf%2C%20verbesserte%20Messmethoden%20der%20K%5Cu00f6rperzusammensetzung%20und%20-fettverteilung%20einzusetzen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Der%20vorliegende%20Beitrag%20stellt%20die%20in%20der%20NAKO%20%28Nationale%20Kohorte%29%20Gesundheitsstudie%20eingesetzten%20Messverfahren%20zur%20Beschreibung%20von%20K%5Cu00f6rperzusammensetzung%20und%20-fettverteilung%20und%20die%20ersten%20deskriptiven%20Ergebnisse%20vor.%20Diese%20beziehen%20sich%20auf%20die%20Daten%20zur%20Halbzeit%20der%20Basiserhebung%2C%20welche%20101.817%20Teilnehmende%20einschlie%5Cu00dft%2C%20die%20in%2018%5Cu00a0Studienzentren%20in%20Deutschland%20zwischen%20M%5Cu00e4rz%202014%20und%20M%5Cu00e4rz%202017%20untersucht%20worden%20sind.%20Die%20anthropometrischen%20Messungen%20umfassten%20K%5Cu00f6rpergewicht%2C%20K%5Cu00f6rpergr%5Cu00f6%5Cu00dfe%20und%20-umf%5Cu00e4nge%2C%20bioelektrische%20Impedanzanalyse%20%28BIA%29%2C%20Sonographie%20des%20Abdominalfettes%2C%203%5Cu2011D-Bodyscanner%20und%20Magnetresonanztomographie.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Die%20Analyse%20des%20BMI%20zeigte%2C%20dass%2046%2C2%5Cu202f%25%20der%20M%5Cu00e4nner%20sowie%2029%2C7%5Cu202f%25%20der%20Frauen%20%5Cu00fcbergewichtig%20und%2023%2C5%5Cu202f%25%20der%20M%5Cu00e4nner%20und%2021%2C2%5Cu202f%25%20der%20Frauen%20adip%5Cu00f6s%20waren.%20Frauen%20wiesen%20im%20Mittel%20in%20fast%20allen%20Altersgruppen%20eine%20h%5Cu00f6here%20Schichtdicke%20an%20subkutanem%20Fettgewebe%20auf%20als%20M%5Cu00e4nner.%20Die%20mittlere%20Schichtdicke%20des%20viszeralen%20Fettgewebes%20lag%20hingegen%20bei%20den%20M%5Cu00e4nnern%20in%20allen%20Altersgruppen%20%5Cu00fcber%20den%20Werten%20der%20Frauen%20und%20stieg%20bei%20beiden%20Geschlechtern%20%5Cu00fcber%20die%20Altersgruppen%20kontinuierlich%20an.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Die%20umfassenden%20Daten%20%5Cu00fcber%20die%20K%5Cu00f6rperfettverteilung%20und%20-zusammensetzung%20erm%5Cu00f6glichen%20es%20zuk%5Cu00fcnftig%2C%20den%20Einfluss%20von%20%5Cu00dcbergewicht%20und%20Adipositas%20auf%20die%20Entstehung%20von%20chronischen%20Erkrankungen%20im%20Detail%20zu%20analysieren.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20High%20levels%20of%20adiposity%20in%20the%20population%20have%20a%5Cu00a0major%20impact%20on%20various%20diseases%2C%20but%20previous%20epidemiologic%20studies%20have%20largely%20been%20restricted%20to%20simple%20anthropometric%20measures%20such%20as%20the%20body%20mass%20index%20%28BMI%29%2C%20an%20imperfect%20predictor%20of%20disease%20risk.%20There%20is%20a%5Cu00a0critical%20need%20for%20the%20use%20of%20improved%20measures%20of%20relative%20weight%20and%20body%20composition%20in%20large-scale%2C%20population-based%20research.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20current%20article%20presents%20initial%20descriptive%20results%20of%20body%20composition%20and%20fat%20distribution%20based%20on%20the%20midterm%20baseline%20dataset%20of%20the%20German%20National%20Cohort%2C%20which%20included%20101%2C817%20participants%20who%20were%20examined%20in%2018%5Cu00a0study%20centers%20in%20Germany%20between%20March%202014%20and%20March%202017.%20The%20anthropometric%20measures%20encompassed%20body%20weight%2C%20height%2C%20waist%20and%20hip%20circumference%2C%20bioelectrical%20impedance%20analysis%20%28BIA%29%2C%20sonography%20of%20abdominal%20adipose%20tissue%2C%203D-body%20scanning%2C%20and%20magnetic%20resonance%20imaging.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20BMI%20analyses%20showed%20that%2046.2%25%20of%20men%20and%2029.7%25%20of%20women%20were%20overweight%20and%2023.5%25%20of%20men%20and%2021.2%25%20of%20women%20were%20obese.%20On%20average%2C%20women%20in%20almost%20all%20age%20groups%20demonstrated%20more%20subcutaneous%20adipose%20tissue%20layer%20thickness%20than%20men.%20The%20mean%20values%20of%20visceral%20adipose%20tissue%20layer%20thickness%2C%20on%20the%20other%20hand%2C%20were%20higher%20among%20men%20than%20among%20women%20in%20all%20age%20groups%20and%20increased%20continuously%20across%20age%20groups%20in%20both%20sexes.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20comprehensive%20assessment%20of%20body%20composition%20and%20fat%20distribution%20provides%20novel%20future%20opportunities%20for%20detailed%20epidemiologic%20analyses%20of%20overweight%20and%20adiposity%20in%20relation%20to%20the%20development%20of%20chronic%20diseases.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03096-w%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03096-w%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A15%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22DUKI7M78%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hassenstein%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHassenstein%20MJ%2C%20Aarabi%20G%2C%20Ahnert%20P%2C%20et%20al.%20Selbst%20berichtete%20Infektionen%20in%20der%20NAKO%20Gesundheitsstudie%20%26%23x2013%3B%20Einordnung%20in%20die%20gegenw%26%23xE4%3Brtige%20Forschungslandschaft.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A404-414.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03114-x%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03114-x%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Selbst%20berichtete%20Infektionen%20in%20der%20NAKO%20Gesundheitsstudie%20%5Cu2013%20Einordnung%20in%20die%20gegenw%5Cu00e4rtige%20Forschungslandschaft%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Max%20J%22%2C%22lastName%22%3A%22Hassenstein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghazal%22%2C%22lastName%22%3A%22Aarabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Ahnert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%22%2C%22lastName%22%3A%22Gl%5Cu00f6ckner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Gottschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9%22%2C%22lastName%22%3A%22Karch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Kerrinnes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berit%22%2C%22lastName%22%3A%22Lange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Nieters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rdis%20J%22%2C%22lastName%22%3A%22Ott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Horn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jansen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Langer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Mangold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Infektionen%20spielen%20f%5Cu00fcr%20das%20Krankheitsempfinden%2C%20f%5Cu00fcr%20gesundheits%5Cu00f6konomische%20%5Cu00dcberlegungen%20sowie%20Public%20Health%20in%20Deutschland%20weiterhin%20eine%20wichtige%20Rolle.%20Sie%20wurden%20in%20den%20letzten%20Jahren%20au%5Cu00dferdem%20mit%20der%20Entstehung%20von%20nicht%5Cu00fcbertragbaren%20Erkrankungen%20in%20Zusammenhang%20gebracht.%20Die%20NAKO%20Gesundheitsstudie%20kann%20Erkenntnisse%20auf%20diesem%20Gebiet%20vertiefen%20und%20damit%20zielgenaueren%20pr%5Cu00e4ventiven%20Ans%5Cu00e4tzen%20den%20Weg%20bereiten.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20infektionsbezogenen%20Erhebungsinstrumente%20sollen%20beschrieben%20und%20in%20Bezug%20zu%20Erhebungsarten%20anderer%20deutscher%20Studien%20gesetzt%20werden.%20Zudem%20werden%20erste%20Daten%20zur%20H%5Cu00e4ufigkeit%20von%20Infektionskrankheiten%20berichtet.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Fragen%20zu%20Infektionskrankheiten%20wurden%20in%20der%20NAKO-Basiserhebung%20sowohl%20im%20Interview%20als%20auch%20im%20Selbstausf%5Cu00fcllerfragebogen%20%28Touchscreen%29%20gestellt.%20Es%20wurden%20die%20Daten%20der%20ersten%20101.787%20Teilnehmenden%20ausgewertet.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Das%20Auftreten%20von%20Herpes%20Zoster%20%28HZ%29%2C%20Post-Zoster-Neuralgie%20%28bei%20Angabe%20von%20HZ%29%2C%20Hepatitis%20B%5C%2FC%2C%20HIV%5C%2FAids%20und%20Tuberkulose%20im%20Sinne%20einer%20%5Cu00e4rztlichen%20Diagnose%20bzw.%20von%20Sepsis%20als%20Grund%20f%5Cu00fcr%20eine%20station%5Cu00e4re%20Behandlung%20wurde%20von%200%2C2%5Cu202f%25%20%28HIV%5C%2FAids%29%20bis%208%2C6%5Cu202f%25%20%28HZ%29%20der%20Befragten%20im%20Interview%20angegeben.%20Im%20Touchscreenmodul%20wurde%20das%20mindestens%20einmalige%20Auftreten%20einer%20Infektion%20der%20oberen%20Atemwege%20%28IOA%29%2C%20der%20unteren%20Atemwege%2C%20des%20Magen-Darm-Traktes%2C%20der%20Harnblase%20oder%20von%20Fieber%20in%20den%20letzten%2012%5Cu00a0Monaten%20von%2012%5Cu202f%25%20%28Zystitis%29%20bis%2081%5Cu202f%25%20%28IOA%29%20berichtet.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ausblick%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Weitere%20Ergebnisse%20anhand%20von%20Daten%20aus%20den%20hier%20vorgestellten%20Frageb%5Cu00f6gen%20sind%20im%20Querschnittsdesign%20%5Cu2013%20beispielsweise%20zu%20Determinanten%20der%20Anf%5Cu00e4lligkeit%20f%5Cu00fcr%20selbst%20berichtete%20Infektionen%20%5Cu2013%20ab%202021%20zu%20erwarten.%20Die%20Bearbeitung%20dar%5Cu00fcber%20hinausgehender%20Forschungsfragen%20der%20Infektionsepidemiologie%20wird%20insbesondere%20nach%20Analysen%20von%20NAKO-Bioproben%20m%5Cu00f6glich%20sein.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Infectious%20diseases%20continue%20to%20play%20an%20important%20role%20for%20disease%20perception%2C%20health-economic%20considerations%20and%20public%20health%20in%20Germany.%20In%20recent%20years%2C%20infectious%20diseases%20have%20been%20linked%20to%20the%20development%20of%20non-communicable%20diseases.%20Analyses%20of%20the%20German%20National%20Cohort%20%28GNC%29%20may%20provide%20deeper%20insights%20into%20this%20issue%20and%20pave%20the%20way%20for%20new%20targeted%20approaches%20in%20disease%20prevention.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20aim%20was%20to%20describe%20the%20tools%20used%20to%20assess%20infectious%20diseases%20and%20to%20present%20initial%20data%20on%20infectious%20disease%20frequencies%2C%20as%20well%20as%20to%20relate%20the%20GNC%20assessment%20tools%20to%20data%20collection%20methods%20in%20other%20studies%20in%20Germany.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20As%20part%20of%20the%20baseline%20examination%2C%20questions%20regarding%20infectious%20diseases%20were%20administered%20using%20both%20an%20interview%20and%20a%5Cu00a0self-administered%20touchscreen%20questionnaire.%20Data%20from%20the%20initial%20101%2C787%20GNC%20participants%20were%20analysed.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20interview%2C%200.2%25%20%28HIV%5C%2FAIDS%29%20to%208.6%25%20%28shingles%29%20of%20respondents%20reported%20ever%20having%20a%5Cu00a0medical%20diagnosis%20of%20shingles%2C%20postherpetic%20neuralgia%20%28in%20cases%20where%20shingles%20was%20reported%29%2C%20hepatitis%20B%5C%2FC%2C%20HIV%5C%2FAIDS%2C%20tuberculosis%20or%20sepsis%20if%20treated%20in%20hospital.%20In%20the%20questionnaire%2C%2012%25%20%28cystitis%29%20to%2081%25%20%28upper%20respiratory%20tract%20infections%29%20of%20respondents%20reported%20having%20experienced%20at%20least%20one%20occurrence%20of%20upper%20or%20lower%20respiratory%20tract%20infections%2C%20gastrointestinal%20infections%2C%20cystitis%20or%20fever%20within%20the%20past%2012%5Cu00a0months.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Outlook%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20cross-sectional%20analyses%20of%20data%20and%20tools%20presented%20here%20%5Cu2013%20for%20example%20on%20determinants%20of%20susceptibility%20to%20self-reported%20infections%20%5Cu2013%20can%20be%20anticipated%20from%20the%20year%202021%20onward.%20Beyond%20that%2C%20more%20extensive%20research%20into%20infectious%20disease%20epidemiology%20will%20follow%2C%20particularly%20once%20analyses%20of%20GNC%20biological%20materials%20have%20been%20performed.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03114-x%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03114-x%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A15%3A09Z%22%7D%7D%2C%7B%22key%22%3A%22SDV4LPIZ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hepp%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHepp%20T%2C%20Fischer%20M%2C%20Winkelmann%20MT%2C%20et%20al.%20Fully%20Automated%20Segmentation%20and%20Shape%20Analysis%20of%20the%20Thoracic%20Aorta%20in%20Non%26%23x2013%3Bcontrast-enhanced%20Magnetic%20Resonance%20Images%20of%20the%20German%20National%20Cohort%20Study.%20%3Ci%3EJournal%20of%20Thoracic%20Imaging%3C%5C%2Fi%3E.%202020%3B35%286%29%3A389-398.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRTI.0000000000000522%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FRTI.0000000000000522%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Fully%20Automated%20Segmentation%20and%20Shape%20Analysis%20of%20the%20Thoracic%20Aorta%20in%20Non%5Cu2013contrast-enhanced%20Magnetic%20Resonance%20Images%20of%20the%20German%20National%20Cohort%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Hepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Moritz%20T.%22%2C%22lastName%22%3A%22Winkelmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Baldenhofer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kuestner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantin%22%2C%22lastName%22%3A%22Nikolaou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%5D%2C%22abstractNote%22%3A%22Purpose%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20purpose%20of%20this%20study%20was%20to%20develop%20and%20validate%20a%20deep%20learning-based%20framework%20for%20automated%20segmentation%20and%20vessel%20shape%20analysis%20on%20non%5Cu2013contrast-enhanced%20magnetic%20resonance%20%28MR%29%20data%20of%20the%20thoracic%20aorta%20within%20the%20German%20National%20Cohort%20%28GNC%29%20MR%20study.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20Methods%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20One%20hundred%20data%20sets%20acquired%20in%20the%20GNC%20MR%20study%20were%20included%20%2856%20men%2C%20average%20age%2053%5Cu2009y%20%5B22%20to%2072%5Cu2009y%5D%29.%20All%20participants%20had%20undergone%20non%5Cu2013contrast-enhanced%20MR%20imaging%20of%20the%20thoracic%20vessels.%20Automated%20vessel%20segmentation%20of%20the%20thoracic%20aorta%20was%20performed%20using%20a%20Convolutional%20Neural%20Network%20in%20a%20supervised%20setting%20with%20manually%20annotated%20data%20sets%20as%20the%20ground%20truth.%20Seventy%20data%20sets%20were%20used%20for%20training%3B%2030%20data%20sets%20were%20used%20for%20quantitative%20and%20qualitative%20evaluation.%20Automated%20shape%20analysis%20based%20on%20centerline%20extraction%20from%20segmentation%20masks%20was%20performed%20to%20derive%20a%20diameter%20profile%20of%20the%20vessel.%20For%20comparison%2C%202%20radiologists%20measured%20vessel%20diameters%20manually.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Overall%2C%20automated%20aortic%20segmentation%20was%20successful%2C%20providing%20good%20qualitative%20analyses%20with%20only%20minor%20irregularities%20in%2029%20of%2030%20data%20sets.%20One%20data%20set%20with%20severe%20MR%20artifacts%20led%20to%20inadequate%20automated%20segmentation%20results.%20The%20mean%20Dice%20score%20of%20automated%20vessel%20segmentation%20was%200.85.%20Automated%20aortic%20diameter%20measurements%20were%20similar%20to%20manual%20measurements%20%28average%20difference%20%5Cu22120.9%5Cu2009mm%2C%20limits%20of%20agreement%3A%20%5Cu22125.4%20to%203.9%5Cu2009mm%29%2C%20with%20minor%20deviations%20in%20the%20order%20of%20the%20interreader%20agreement%20between%20the%202%20radiologists%20%28average%20difference%20%5Cu22120.5%5Cu2009mm%2C%20limits%20of%20agreement%3A%20%5Cu22125.8%20to%204.8%5Cu2009mm%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%3A%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Automated%20segmentation%20and%20shape%20analysis%20of%20the%20thoracic%20aorta%20is%20feasible%20with%20high%20accuracy%20on%20non%5Cu2013contrast-enhanced%20MR%20imaging%20using%20the%20proposed%20deep%20learning%20approach.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1097%5C%2FRTI.0000000000000522%22%2C%22ISSN%22%3A%220883-5993%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.lww.com%5C%2F10.1097%5C%2FRTI.0000000000000522%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A14%3A59Z%22%7D%7D%2C%7B%22key%22%3A%22N443YDUT%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Holtfreter%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EHoltfreter%20B%2C%20Samietz%20S%2C%20Hertrampf%20K%2C%20et%20al.%20Design%20und%20Qualit%26%23xE4%3Btskontrolle%20der%20zahnmedizinischen%20Untersuchung%20in%20der%20NAKO%20Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A426-438.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03107-w%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03107-w%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Design%20und%20Qualit%5Cu00e4tskontrolle%20der%20zahnmedizinischen%20Untersuchung%20in%20der%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Birte%22%2C%22lastName%22%3A%22Holtfreter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Samietz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Hertrampf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ghazal%22%2C%22lastName%22%3A%22Aarabi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Hagenfeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ti-Sun%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Kocher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Koos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Schmitter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22Alwers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Fr%5Cu00f6lich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anton%22%2C%22lastName%22%3A%22Gies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lamiaa%22%2C%22lastName%22%3A%22Hassan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22W.%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Wigmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20Oliver%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22K%5Cu00fchnisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rupf%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Karies%20und%20Parodontitis%20sind%20weltweit%20hoch%20pr%5Cu00e4valente%20Erkrankungen.%20Durch%20ihre%20Erfassung%20im%20Rahmen%20der%20NAKO%20Gesundheitsstudie%20k%5Cu00f6nnen%20Assoziationen%20zwischen%20oralen%20und%20systemischen%20Erkrankungen%20untersucht%20werden.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Fragestellung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20einer%20ersten%20Qualit%5Cu00e4tsanalyse%20zur%20Halbzeit%20der%20NAKO-Basiserhebung%20wird%20die%20Plausibilit%5Cu00e4t%20der%20zahnmedizinischen%20Ergebnisse%20%5Cu00fcberpr%5Cu00fcft.%20Es%20werden%20Ma%5Cu00dfnahmen%20zur%20Verbesserung%20der%20Datenqualit%5Cu00e4t%20vorgeschlagen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ein%20zahnmedizinisches%20Interview%2C%20eine%20Speichelprobengewinnung%20und%20eine%20Befunderhebung%20wurden%20durchgef%5Cu00fchrt.%20Im%20Rahmen%20der%20Level-1-Untersuchung%20wurden%20Zahn-%20und%20Prothesenanzahl%20erfasst.%20In%20der%20Level-2-Untersuchung%20wurden%20detaillierte%20parodontologische%2C%20kariologische%20und%20funktionelle%20Befunde%20erhoben.%20Alle%20Untersuchungen%20wurden%20von%20geschultem%20nichtzahnmedizinischen%20Personal%20durchgef%5Cu00fchrt.%20Es%20wurden%20Plausibilit%5Cu00e4tspr%5Cu00fcfungen%20durchgef%5Cu00fchrt%20sowie%20Verteilungen%20deskriptiv%20dargestellt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20die%20Analysen%20gingen%20Daten%20von%2057.967%20Interviewteilnehmer%2Ainnen%2C%2056.913%20Level-1-%20und%206295%20Level-2-Teilnehmer%2Ainnen%20ein.%20Der%20Anteil%20fehlender%20Werte%20lag%20f%5Cu00fcr%20die%20einzelnen%20Parameter%20der%20Level-1-%20und%20Level-2-Untersuchungen%20zwischen%200%2C02%5Cu202f%25%20und%203%2C9%5Cu202f%25.%20Die%20Parameter%20zeigten%20eine%20plausible%20Verteilung%3B%20vereinzelt%20wurden%20unplausible%20Werte%20beobachtet%2C%20z.%5Cu202fB.%20beim%20horizontalen%20und%20vertikalen%20%5Cu00dcberbiss%20%28Overjet%20und%20Overbite%29.%20Anhand%20der%20Intraklassenkorrelationskoeffizienten%20wurden%20f%5Cu00fcr%20die%20einzelnen%20Parameter%20Unterschiede%20zwischen%20regionalen%20Clustern%2C%20den%20Studienzentren%20und%20verschiedenen%20Untersucher%2Ainnen%20nachgewiesen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20bisherigen%20Ergebnisse%20best%5Cu00e4tigten%20die%20Umsetzbarkeit%20des%20Studienprotokolls%20durch%20nichtzahnmedizinisches%20Personal%20und%20die%20erfolgreiche%20Integration%20in%20das%20Untersuchungsprogramm%20der%20NAKO%20Gesundheitsstudie.%20Die%20Studienzentren%20ben%5Cu00f6tigen%20eine%20intensive%20zahnmedizinische%20Betreuung%20f%5Cu00fcr%20das%20Qualit%5Cu00e4tsmanagement.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Caries%20and%20periodontitis%20are%20highly%20prevalent%20worldwide.%20Because%20detailed%20data%20on%20these%20oral%20diseases%20were%20collected%20within%20the%20framework%20of%20the%20German%20National%20Cohort%20%28GNC%29%2C%20associations%20between%20oral%20and%20systemic%20diseases%20and%20conditions%20can%20be%20investigated.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20study%20protocol%20for%20the%20oral%20examination%20was%20designed%20to%20ensure%20a%5Cu00a0comprehensive%20collection%20of%20dental%20findings%20by%20trained%20non-dental%20staff%20within%20a%5Cu00a0limited%20examination%20time.%20At%20the%20mid-term%20of%20the%20GNC%20baseline%20examination%2C%20a%5Cu00a0first%20quality%20evaluation%20was%20performed%20to%20check%20the%20plausibility%20of%20results%20and%20to%20propose%20measures%20to%20improve%20the%20data%20quality.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%5Cu00a0dental%20interview%2C%20saliva%20sampling%20and%20oral%20diagnostics%20were%20conducted.%20As%20part%20of%20the%20level%5Cu20111%20examination%2C%20the%20number%20of%20teeth%20and%20prostheses%20were%20recorded.%20As%20part%20of%20the%20level%5Cu20112%20examination%2C%20detailed%20periodontal%2C%20cariological%20and%20functional%20aspects%20were%20examined.%20All%20examinations%20were%20conducted%20by%20trained%20non-dental%20personnel.%20Parameters%20were%20checked%20for%20plausibility%20and%20variable%20distributions%20were%20descriptively%20analysed.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Analyses%20included%20data%20of%2057%2C967%20interview%20participants%2C%2056%2C913%20level%5Cu20111%20participants%20and%206295%20level%5Cu20112%20participants.%20Percentages%20of%20missing%20values%20for%20individual%20clinical%20parameters%20assessed%20in%20level%5Cu00a01%20and%20level%5Cu00a02%20ranged%20between%200.02%20and%203.9%25.%20Results%20showed%20a%5Cu00a0plausible%20distribution%20of%20the%20data%3B%20rarely%2C%20implausible%20values%20were%20observed%2C%20e.g.%20for%20measurements%20of%20horizontal%20and%20vertical%20overbite%20%28overjet%20and%20overbite%29.%20Intra-class%20correlation%20coefficients%20indicated%20differences%20in%20individual%20parameters%20between%20regional%20clusters%2C%20study%20centres%20and%20across%20different%20examiners.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20results%20confirm%20the%20feasibility%20of%20the%20study%20protocol%20by%20non-dental%20personnel%20and%20its%20successful%20integration%20into%20the%20GNC%5Cu2019s%20overall%20assessment%20program.%20However%2C%20rigorous%20dental%20support%20of%20the%20study%20centres%20is%20required%20for%20quality%20management.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03107-w%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03107-w%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A13%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22MM7QERW4%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jaeschke%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJaeschke%20L%2C%20Steinbrecher%20A%2C%20Greiser%20KH%2C%20et%20al.%20Erfassung%20selbst%20berichteter%20kardiovaskul%26%23xE4%3Brer%20und%20metabolischer%20Erkrankungen%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Methoden%20und%20erste%20Ergebnisse.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A439-451.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03108-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03108-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Erfassung%20selbst%20berichteter%20kardiovaskul%5Cu00e4rer%20und%20metabolischer%20Erkrankungen%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Methoden%20und%20erste%20Ergebnisse%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Steinbrecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22D%5Cu00f6rr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Buck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22Braun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna-Therese%22%2C%22lastName%22%3A%22Lehnich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Aus%20der%20NAKO%20Gesundheitsstudie%2C%20der%20gr%5Cu00f6%5Cu00dften%20deutschen%20bev%5Cu00f6lkerungsbasierten%20Studie%20zur%20Gesundheit%2C%20liegen%20die%20Daten%20zu%20selbst%20berichteten%20kardiovaskul%5Cu00e4ren%20und%20metabolischen%20Erkrankungen%20der%20ersten%20ca.%5Cu00a0100.000%20Teilnehmenden%20vor.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Beschreibung%20der%20Methoden%20zur%20Erhebung%20sowie%20Berechnung%20der%20H%5Cu00e4ufigkeit%20kardiovaskul%5Cu00e4rer%20und%20metabolischer%20Erkrankungen%20in%20der%20NAKO.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20101.806%20Teilnehmende%20%2820%5Cu201375%5Cu00a0Jahre%2C%2046%5Cu202f%25%20M%5Cu00e4nner%29%20aus%2018%20bundesweiten%20Studienzentren%20wurden%20in%20einem%20computergest%5Cu00fctzten%2C%20standardisierten%20pers%5Cu00f6nlichen%20Interview%20gebeten%2C%20anhand%20einer%20vorgegebenen%20Liste%20anzugeben%2C%20welche%20Erkrankungen%20bei%20ihnen%20jemals%20%5Cu00e4rztlich%20diagnostiziert%20wurden%2C%20darunter%20auch%20kardiovaskul%5Cu00e4re%20und%20metabolische%20Erkrankungen.%20F%5Cu00fcr%20Letztere%20wurden%20deren%20geschlechtsspezifische%20relative%20H%5Cu00e4ufigkeiten%20berechnet%20und%20diese%20mit%20Referenzzahlen%20verglichen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Bezogen%20auf%20die%20kardiovaskul%5Cu00e4ren%20Erkrankungen%20berichteten%203%2C5%5Cu202f%25%20der%20M%5Cu00e4nner%20und%200%2C8%5Cu202f%25%20der%20Frauen%2C%20jemals%20einen%20Herzinfarkt%20diagnostiziert%20bekommen%20zu%20haben%2C%204%2C8%5Cu202f%25%20bzw.%201%2C5%5Cu202f%25%20eine%20Angina%20pectoris%2C%203%2C5%5Cu202f%25%20bzw.%202%2C5%5Cu202f%25%20eine%20Herzinsuffizienz%2C%2010%2C1%5Cu202f%25%20bzw.%2010%2C4%5Cu202f%25%20Herzrhythmusst%5Cu00f6rungen%2C%202%2C7%5Cu202f%25%20bzw.%201%2C8%5Cu202f%25%20eine%20Claudicatio%20intermittens%20und%2034%2C6%5Cu202f%25%20bzw.%2027%2C0%5Cu202f%25%20eine%20arterielle%20Hypertonie.%20Die%20H%5Cu00e4ufigkeit%20berichteter%20diagnostizierter%20metabolischer%20Erkrankungen%20lag%20bei%208%2C1%5Cu202f%25%20bzw.%205%2C8%5Cu202f%25%20f%5Cu00fcr%20Diabetes%20mellitus%2C%20bei%2028%2C6%5Cu202f%25%20bzw.%2024%2C5%5Cu202f%25%20f%5Cu00fcr%20Hyperlipid%5Cu00e4mie%2C%20bei%207%2C9%5Cu202f%25%20bzw.%202%2C4%5Cu202f%25%20f%5Cu00fcr%20Gicht%20und%20bei%2010%2C1%5Cu202f%25%20bzw.%2034%2C3%5Cu202f%25%20f%5Cu00fcr%20Schilddr%5Cu00fcsenerkrankungen.%20Die%20beobachteten%20H%5Cu00e4ufigkeiten%20lagen%20insgesamt%20etwas%20niedriger%20als%20Vergleichsdaten%20f%5Cu00fcr%20Deutschland.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20NAKO%20erhebt%20von%20allen%20Teilnehmenden%20selbst%20berichtete%2C%20%5Cu00e4rztlich%20diagnostizierte%20kardiovaskul%5Cu00e4re%20und%20metabolische%20Erkrankungen%20und%20stellt%20damit%20eine%20Datenressource%20f%5Cu00fcr%20weitergehende%20kardiometabolische%20Forschungsfragestellungen%20dar.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20on%20self-reported%20cardiovascular%20and%20metabolic%20diseases%20are%20available%20for%20the%20first%20100%2C000%20participants%20of%20the%20population-based%20German%20National%20Cohort%20%28GNC%2C%20NAKO%20Gesundheitsstudie%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20To%20describe%20assessment%20methods%20and%20the%20frequency%20of%20self-reported%20cardiovascular%20and%20metabolic%20diseases%20in%20the%20German%20National%20Cohort.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Using%20a%5Cu00a0computer-based%2C%20standardized%20personal%20interview%2C%20101%2C806%20participants%20%2820%5Cu201375%5Cu00a0years%2C%2046%25%20men%29%20from%2018%5Cu00a0nationwide%20study%20centres%20were%20asked%20to%20use%20a%5Cu00a0predefined%20list%20to%20report%20medical%20conditions%20ever%20diagnosed%20by%20a%5Cu00a0physician%2C%20including%20cardiovascular%20or%20metabolic%20diseases.%20For%20the%20latter%2C%20we%20calculated%20sex-stratified%20relative%20frequencies%20and%20compared%20these%20with%20reference%20data.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20With%20regard%20to%20cardiovascular%20diseases%2C%203.5%25%20of%20men%20and%200.8%25%20of%20women%20reported%20to%20have%20ever%20been%20diagnosed%20with%20a%5Cu00a0myocardial%20infarction%2C%204.8%25%20and%201.5%25%20with%20angina%20pectoris%2C%203.5%25%20and%202.5%25%20with%20heart%20failure%2C%2010.1%25%20and%2010.4%25%20with%20cardiac%20arrhythmia%2C%202.7%25%20and%201.8%25%20with%20claudicatio%20intermittens%2C%20and%2034.6%25%20and%2027.0%25%20with%20arterial%20hypertension.%20The%20frequencies%20of%20self-reported%20diagnosed%20metabolic%20diseases%20were%208.1%25%20and%205.8%25%20for%20diabetes%20mellitus%2C%2028.6%25%20and%2024.5%25%20for%20hyperlipidaemia%2C%207.9%25%20and%202.4%25%20for%20gout%2C%20and%2010.1%25%20and%2034.3%25%20for%20thyroid%20diseases.%20Observed%20disease%20frequencies%20were%20lower%20than%20reference%20data%20for%20Germany.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20German%20National%20Cohort%2C%20self-reported%20cardiovascular%20and%20metabolic%20diseases%20diagnosed%20by%20a%5Cu00a0physician%20are%20assessed%20from%20all%20participants%2C%20therefore%20representing%20a%5Cu00a0data%20source%20for%20future%20cardio-metabolic%20research%20in%20this%20cohort.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03108-9%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03108-9%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A13%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22YGGLRW8D%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Karrasch%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKarrasch%20S%2C%20Peters%20A%2C%20Meisinger%20C%2C%20et%20al.%20Lungenfunktion%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Methoden%20und%20erste%20Ergebnisse.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A322-331.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03102-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03102-1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Lungenfunktion%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Methoden%20und%20erste%20Ergebnisse%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Karrasch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maike%22%2C%22lastName%22%3A%22Ferland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirko%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Langer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Sedlmeier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Holger%22%2C%22lastName%22%3A%22Schulz%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Eine%20Erhebung%20des%20respiratorischen%20Gesundheitszustandes%20auf%20Grundlage%20bundesweit%20einheitlich%20durchgef%5Cu00fchrter%20Lungenfunktionsmessungen%20lag%20in%20Deutschland%20bislang%20nicht%20vor.%20Dieser%20Beitrag%20beschreibt%20das%20Vorgehen%20bei%20der%20Untersuchung%20der%20Lungenfunktion%20in%20der%20NAKO%20Gesundheitsstudie%20und%20stellt%20erste%20Ergebnisse%20auf%20der%20Datenbasis%20zur%20Halbzeit%20der%20Basiserhebung%20vor.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Es%20wurden%20eine%20Spirometrie%20%28Level%5Cu00a01%29%20und%20eine%20Messung%20des%20exhalierten%20Stickstoffmonoxids%20%28FeNO%2C%20Level%5Cu00a02%29%20durchgef%5Cu00fchrt.%20Das%20Qualit%5Cu00e4tssicherungskonzept%20beinhaltete%20regelm%5Cu00e4%5Cu00dfige%20Schulungen%20der%20Lungenfunktionspr%5Cu00fcfung%20an%20verschiedenen%20NAKO-Standorten%2C%20Zwischenauswertungen%20zur%20Untersuchungsqualit%5Cu00e4t%20und%20regelm%5Cu00e4%5Cu00dfige%20Kalibrations%5Cu2011%5C%2FMesskontrollen%20der%20Untersuchungsger%5Cu00e4te.%20F%5Cu00fcr%20die%20Spirometrie%20wurde%20zudem%20ein%20stufenweises%20Vorgehen%20zur%20Offlinequalit%5Cu00e4tskontrolle%20auf%20Basis%20der%20Fluss-Volumen-Rohkurven%20etabliert.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20den%20betrachteten%20Daten%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu2009101.734%29%20lag%20eine%20Spirometrie%20bei%2086.893%20Teilnehmenden%20und%20eine%20FeNO-Messung%20bei%2015.228%20Teilnehmenden%20vor.%20Es%20fand%20sich%20im%20Mittel%20%28%5Cu00b1SD%29%20f%5Cu00fcr%20die%20Einsekundenkapazit%5Cu00e4t%20%28FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20ein%20Z%5Cu2011Score%20%28gem%5Cu00e4%5Cu00df%20GLI%202012%29%20von%20%5Cu22120%2C321%5Cu202f%5Cu00b1%5Cu20091%2C047%2C%20f%5Cu00fcr%20die%20forcierte%20Vitalkapazit%5Cu00e4t%20%28FVC%29%20ein%20Z%5Cu2011Score%20von%20%5Cu22120%2C153%5Cu202f%5Cu00b1%5Cu20090%2C941%20und%20f%5Cu00fcr%20den%20Tiffeneau-Index%20%28FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5C%2FFVC%29%20ein%20Z%5Cu2011Score%20von%20%5Cu22120%2C337%5Cu202f%5Cu00b1%5Cu20090%2C901.%20Die%20Differenz%20in%20FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5C%2FFVC%20zwischen%20Rauchern%20und%20Nie-Rauchern%20stieg%20mit%20dem%20Alter%20an.%20FeNO%20lag%20im%20geometrischen%20Mittel%20bei%2014%2C2%5Cu202f%5Cu00f7%5Cu20092%2C0%5Cu202fppb%2C%20bei%20aktiven%20Rauchern%20war%20FeNO%20um%2043%5Cu202f%25%20vermindert%2C%20bei%20Nie%5Cu2011%5C%2FEx-Rauchern%20mit%20respiratorischer%20Allergie%20um%2016%5Cu202f%25%20erh%5Cu00f6ht.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20Ergebnisse%20der%20Spirometrie%20und%20FeNO-Messungen%20liegen%20bez%5Cu00fcglich%20ihrer%20Verteilungen%20und%20bekannter%20Einflussgr%5Cu00f6%5Cu00dfen%20im%20erwarteten%20Bereich.%20Die%20NAKO%20liefert%20damit%20die%20Datenbasis%20zur%20Untersuchung%20der%20Atemwegsgesundheit%20und%20ihrer%20Determinanten%20sowie%20zur%20Eruierung%20der%20M%5Cu00f6glichkeiten%20zur%20Pr%5Cu00e4vention%20respiratorischer%20Erkrankungen%20in%20Deutschland.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%5Cu00a0nationwide%20assessment%20of%20the%20respiratory%20status%20on%20the%20basis%20of%20standardized%20lung%20function%20measurements%20has%20so%20far%20not%20been%20available%20in%20Germany.%20The%20present%20work%20describes%20the%20lung%20function%20tests%20in%20the%20German%20National%20Cohort%20%28GNC%29%20and%20presents%20initial%20results%20based%20on%20the%20GNC%20Midterm%20Baseline%20Dataset.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20and%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20assessment%20of%20lung%20function%20in%20the%20GNC%20comprised%20spirometry%20%28level%5Cu00a01%29%20and%20the%20determination%20of%20exhaled%20nitric%20oxide%20%28FeNO%2C%20level%5Cu00a02%29.%20Our%20quality%20assurance%20concept%20included%20regular%20training%20of%20lung%20function%20test%20procedures%20at%20various%20GNC%20sites%2C%20interim%20evaluations%20of%20test%20quality%2C%20as%20well%20as%20regular%20calibration%5C%2Fmeasurement%20checks%20of%20test%20equipment.%20For%20spirometry%2C%20we%20established%20a%5Cu00a0stepwise%20procedure%20for%20offline%20quality%20control%20based%20on%20raw%20flow%20volume%20curves.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20present%20dataset%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu2009101%2C734%29%2C%20spirometry%20was%20available%20for%2086%2C893%20study%20participants%20and%20FeNO%20was%20available%20for%2015%2C228%20participants.%20The%20average%20%28%5Cu00b1SD%29%20FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Z%5Cu00a0score%20%28according%20to%20GLI%202012%29%20was%20%5Cu22120.321%5Cu202f%5Cu00b1%5Cu20091.047%2C%20the%20FVC%20Z%5Cu00a0score%20was%20%5Cu22120.153%5Cu202f%5Cu00b1%5Cu20090.941%2C%20and%20the%20FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5C%2FFVC%20Z%5Cu00a0score%20was%20%5Cu22120.337%5Cu202f%5Cu00b1%5Cu20090.901.%20The%20difference%20in%20FEV%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%201%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5C%2FFVC%20between%20current%20smokers%20and%20never-smokers%20increased%20with%20age.%20The%20average%20FeNO%20was%2014.2%5Cu202f%5Cu00f7%5Cu20092.0%5Cu202fppb.%20Current%20smoking%20reduced%20FeNO%20levels%20by%2043%25%2C%20whereas%20respiratory%20allergy%20increased%20FeNO%20levels%20by%2016%25%20in%20nonsmokers.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20results%20of%20spirometry%20and%20the%20FeNO%20measurements%20are%20in%20the%20expected%20range%20with%20regard%20to%20their%20distributions%20and%20correlates.%20The%20GNC%20provides%20a%5Cu00a0valuable%20basis%20for%20future%20investigations%20of%20respiratory%20health%20and%20its%20determinants%20as%20well%20as%20research%20into%20the%20prevention%20of%20respiratory%20diseases%20in%20Germany.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03102-1%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03102-1%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A12%3A56Z%22%7D%7D%2C%7B%22key%22%3A%229FHATYK5%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kluttig%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKluttig%20A%2C%20Zschocke%20J%2C%20Haerting%20J%2C%20et%20al.%20Messung%20der%20k%26%23xF6%3Brperlichen%20Fitness%20in%20der%20NAKO%20Gesundheitsstudie%20%26%23x2013%3B%20Methoden%2C%20Qualit%26%23xE4%3Btssicherung%20und%20erste%20deskriptive%20Ergebnisse.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A312-321.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03100-3%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03100-3%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Messung%20der%20k%5Cu00f6rperlichen%20Fitness%20in%20der%20NAKO%20Gesundheitsstudie%20%5Cu2013%20Methoden%2C%20Qualit%5Cu00e4tssicherung%20und%20erste%20deskriptive%20Ergebnisse%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Zschocke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Haerting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Schmermund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Hillreiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Baumeister%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ole%22%2C%22lastName%22%3A%22Sprengeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gerhard%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Kalinowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms%20Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Hoffmeister%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Weber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadja%22%2C%22lastName%22%3A%22Kartschmit%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirko%22%2C%22lastName%22%3A%22Brandes%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Die%20k%5Cu00f6rperliche%20Fitness%20ist%20das%20Ma%5Cu00df%20f%5Cu00fcr%20die%20individuelle%20F%5Cu00e4higkeit%2C%20k%5Cu00f6rperlich%20aktiv%20zu%20sein.%20Ihre%20wesentlichen%20Komponenten%20sind%20die%20kardiorespiratorische%20Fitness%20%28Cardiorespiratory%20Fitness%2C%20CRF%29%2C%20die%20Muskelkraft%20und%20die%20Beweglichkeit.%20Neben%20der%20k%5Cu00f6rperlichen%20Aktivit%5Cu00e4t%20ist%20die%20k%5Cu00f6rperliche%20Fitness%20ein%20wesentlicher%20Pr%5Cu00e4diktor%20f%5Cu00fcr%20Morbidit%5Cu00e4t%20und%20Mortalit%5Cu00e4t.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20der%20Arbeit%20sind%20die%20Beschreibung%20der%20Erhebungsmethoden%20k%5Cu00f6rperlicher%20Fitness%20in%20der%20NAKO%20Gesundheitsstudie%20und%20die%20Darstellung%20erster%20deskriptiver%20Ergebnisse.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20der%20NAKO-Basiserhebung%20wurden%20die%20maximale%20Handgreifkraft%20%28Grip%20Strength%2C%20GS%29%20und%20die%20CRF%20als%20Komponenten%20der%20k%5Cu00f6rperlichen%20Fitness%20%5Cu00fcber%20ein%20Handdynamometer%20bzw.%20%5Cu00fcber%20einen%20Fahrradergometertest%20mit%20submaximaler%20Belastung%20erhoben.%20Daraus%20wurde%20die%20maximale%20Sauerstoffaufnahme%20%28VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20zur%20Beurteilung%20der%20CRF%20abgeleitet.%20Die%20Ergebnisse%20von%20insgesamt%2099.068%20GS-Messungen%20und%203094%20Messungen%20der%20CRF%20beruhen%20auf%20einem%20Datensatz%20zur%20Halbzeit%20der%20Basiserhebung%20der%20NAKO%20%28Alter%2020%5Cu201373%5Cu00a0Jahre%2C%2047%5Cu202f%25%20M%5Cu00e4nner%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20M%5Cu00e4nner%20zeigten%20im%20Vergleich%20zu%20Frauen%20h%5Cu00f6here%20Werte%20der%20k%5Cu00f6rperlichen%20Fitness%20%28M%5Cu00e4nner%3A%20GS%5Cu202f%3D%5Cu200947%2C8%5Cu202fkg%2C%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu200936%2C4%5Cu202fml%5Cu00b7min%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%5Cu00b7%5Cu2009kg%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3B%20Frauen%3A%20GS%5Cu202f%3D%5Cu200929%2C9%5Cu202fkg%2C%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu200932%2C3%5Cu202fml%5Cu00b7min%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%5Cu00b7%5Cu2009kg%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29.%20Ungef%5Cu00e4hr%20ab%20dem%2050.%5Cu00a0Lebensjahr%20konnte%20ein%20R%5Cu00fcckgang%20der%20GS%20verzeichnet%20werden%2C%20wohingegen%20die%20CRF%20ab%20der%20Altersgruppe%2020%5Cu201329%20Jahre%20bis%20zu%20den%20%5Cu226560-J%5Cu00e4hrigen%20kontinuierlich%20abfiel.%20Die%20GS%20und%20die%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20zeigten%20nach%20Korrektur%20f%5Cu00fcr%20das%20K%5Cu00f6rpergewicht%20einen%20linear%20positiven%20Zusammenhang%20%28M%5Cu00e4nner%20%5Cu03b2%5Cu202f%3D%5Cu20090%2C21%3B%20Frauen%20%5Cu03b2%5Cu202f%3D%5Cu20090%2C35%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Die%20Analysen%20zeigten%20eine%20gute%20%5Cu00dcbereinstimmung%20der%20Verteilung%20der%20k%5Cu00f6rperlichen%20Fitness%20in%20der%20NAKO%20im%20Vergleich%20zu%20anderen%20bev%5Cu00f6lkerungsbasierten%20Studien.%20Zuk%5Cu00fcnftige%20Auswertungen%20werden%20insbesondere%20die%20unabh%5Cu00e4ngige%20Bedeutung%20der%20GS%20und%20CRF%20bei%20der%20Pr%5Cu00e4diktion%20von%20Morbidit%5Cu00e4t%20und%20Mortalit%5Cu00e4t%20beleuchten.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Physical%20fitness%20is%20defined%20as%20an%20individual%5Cu2019s%20ability%20to%20be%20physically%20active.%20The%20main%20components%20are%20cardiorespiratory%20fitness%20%28CRF%29%2C%20muscle%20strength%2C%20and%20flexibility.%20Regardless%20of%20physical%20activity%20level%2C%20physical%20fitness%20is%20an%20important%20determinant%20of%20morbidity%20and%20mortality.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20aim%20of%20the%20current%20study%20was%20to%20describe%20the%20physical%20fitness%20assessment%20methodology%20in%20the%20German%20National%20Cohort%20%28NAKO%29%20and%20to%20present%20initial%20descriptive%20results%20in%20a%5Cu00a0subsample%20of%20the%20cohort.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20NAKO%2C%20hand%20grip%20strength%20%28GS%29%20and%20CRF%20as%20physical%20fitness%20components%20were%20assessed%20at%20baseline%20using%20a%5Cu00a0hand%20dynamometer%20and%20a%5Cu00a0submaximal%20bicycle%20ergometer%20test%2C%20respectively.%20Maximum%20oxygen%20uptake%20%28VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20was%20estimated%20as%20a%5Cu00a0result%20of%20the%20bicycle%20ergometer%20test.%20The%20results%20of%20a%5Cu00a0total%20of%2099%2C068%20GS%20measurements%20and%203094%20CRF%20measurements%20are%20based%20on%20a%5Cu00a0data%20set%20at%20halftime%20of%20the%20NAKO%20baseline%20survey%20%28age%2020%5Cu201373%5Cu00a0years%2C%2047%25%20men%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Males%20showed%20higher%20values%20of%20physical%20fitness%20compared%20to%20women%20%28males%3A%20GS%5Cu202f%3D%5Cu200947.8%5Cu202fkg%2C%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu200936.4%5Cu202fml%5Cu00b7min%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%5Cu00b7%5Cu2009kg%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3B%20females%3A%20GS%5Cu202f%3D%5Cu200929.9%5Cu202fkg%2C%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu200932.3%5Cu202fml%5Cu202f%5Cu00b7%5Cu2009min%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%5Cu00b7%5Cu2009kg%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu22121%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29.%20GS%20declined%20from%20the%20age%20of%2050%5Cu00a0onwards%2C%20whereas%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20levels%20decreased%20continuously%20between%20the%20age%20groups%20of%2020%5Cu201329%20and%20%5Cu226560%5Cu00a0years.%20GS%20and%20VO%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%202max%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20showed%20a%5Cu00a0linear%20positive%20association%20after%20adjustment%20for%20body%20weight%20%28males%20%5Cu03b2%5Cu202f%3D%5Cu20090.21%3B%20females%20%5Cu03b2%5Cu202f%3D%5Cu20090.35%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20These%20results%20indicate%20that%20the%20physical%20fitness%20measured%20in%20the%20NAKO%20are%20comparable%20to%20other%20population-based%20studies.%20Future%20analyses%20in%20this%20study%20will%20focus%20on%20examining%20the%20independent%20relations%20of%20GS%20and%20CRF%20with%20risk%20of%20morbidity%20and%20mortality.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03100-3%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03100-3%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A12%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22AYZB86FM%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kraus%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EKraus%20FB%2C%20Kocijancic%20M%2C%20Kluttig%20A%2C%20Ludwig-Kraus%20B.%20Test%20validation%2C%20method%20comparison%20and%20reference%20range%20for%20the%20measurement%20of%20%26%23x3B2%3B-hydroxybutyrate%20in%20peripheral%20blood%20samples.%20%3Ci%3EBiochem%20med%20%28Online%29%3C%5C%2Fi%3E.%202020%3B30%281%29%3A118-127.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.11613%5C%2FBM.2020.010707%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.11613%5C%2FBM.2020.010707%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Test%20validation%2C%20method%20comparison%20and%20reference%20range%20for%20the%20measurement%20of%20%5Cu03b2-hydroxybutyrate%20in%20peripheral%20blood%20samples%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%20Bernhard%22%2C%22lastName%22%3A%22Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marija%22%2C%22lastName%22%3A%22Kocijancic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Ludwig-Kraus%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%3A%20The%20measurement%20of%20%5Cu03b2-hydroxybutyrate%20%28%5Cu03b2OHB%29%20concentrations%20is%20a%20corner%20stone%20of%20the%20diagnosis%20of%20diabetic%20ketoacidosis%20and%20other%20ketonic%20states.%20The%20aim%20of%20this%20study%20was%20to%20perform%20a%20validation%20of%20a%20peripheral%20blood%20%5Cu03b2OHB%20assay%20%28Randox%29%20on%20a%20Roche%20cobas%20c502%20analyser%20and%20to%20establish%20a%20%5Cu03b2OHB%20reference%20range%20for%20the%20validated%20assay.%20%5CnMaterials%20and%20methods%3A%20Precision%2C%20linearity%20and%20limit%20of%20detection%20and%20blank%20%28LoD%2C%20LoB%29%20were%20determined%20according%20to%20Clinical%20and%20Laboratory%20%5CnStandards%20Institute%20%28CLSI%29%20EP05-A3%2C%20EP%2006-A%20and%20EP17-A2%20guidelines%2C%20using%20commercial%20control%20material%20and%20residual%20patient%20sample%20pools.%20As%20method%20comparison%2C%20for%20190%20semi-quantitative%20measurements%20of%20urine%20ketones%20we%20determined%20the%20corresponding%20%5Cu03b2OHB%20blood%20concentration.%20The%20reference%20range%20was%20based%20on%20the%20CLSI%20C28-A3%20guideline%2C%20using%20304%20randomly%20selected%20serum%20samples%20from%20population%20based%20German%20National%20Cohort%20%28GNC%29%20study.%20%5CnResults%3A%20Coefficients%20of%20variation%20for%20the%20validated%20assay%20ranged%20from%201.5%25%20for%20high%20concentrations%20%283.1%20mmol%5C%2FL%29%20to%206.5%25%20for%20low%20concentrations%20%280.1%20mmol%5C%2FL%29.%20Detection%20capacity%20was%20LoB%20%3D%200.011%20mmol%5C%2FL%20and%20LoD%20%3D%200.037%20mmol%5C%2FL.%20Linearity%20of%20the%20assay%20ranged%20from%200.10%20to%203.95%20mmol%5C%2FL.%20The%20agreement%20between%20the%20semi-quantitative%20urine%20ketone%20test%20and%20the%20%5Cu03b2OHB%20blood%20test%20was%20moderate%20%28Kappa%20%3D%200.66%29.%20The%20obtained%2095%25%20serum%20reference%20range%20was%20estimated%20as%200.02%20to%200.28%20mmol%5C%2Fl%20%5Cu03b2OHB.%20%5CnConclusions%3A%20The%20Ranbut%20%5Cu03b2OHB%20assay%20showed%20good%20precision%20and%20analytical%20performance.%20Our%20results%20confirm%20that%20%5Cu03b2OHB%20measurement%20in%20peripheral%20blood%20is%20indeed%20a%20preferable%20alternative%20to%20the%20semi-quantitative%20measurement%20of%20urine%20ketones.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.11613%5C%2FBM.2020.010707%22%2C%22ISSN%22%3A%2218467482%2C%2013300962%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.biochemia-medica.com%5C%2Fen%5C%2Fjournal%5C%2F30%5C%2F1%5C%2F10.11613%5C%2FBM.2020.010707%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A12%3A25Z%22%7D%7D%2C%7B%22key%22%3A%224MRL8RV8%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Langer%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELanger%20S%2C%20Horn%20J%2C%20Kluttig%20A%2C%20et%20al.%20H%26%23xE4%3Bufigkeit%20von%20Asthma%20bronchiale%20und%20Alter%20bei%20der%20Erstdiagnose%20%26%23x2013%3B%20erste%20Ergebnisse%20der%20NAKO%20Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A397-403.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03105-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03105-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22H%5Cu00e4ufigkeit%20von%20Asthma%20bronchiale%20und%20Alter%20bei%20der%20Erstdiagnose%20%5Cu2013%20erste%20Ergebnisse%20der%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%22%2C%22lastName%22%3A%22Langer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Horn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Karrasch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Holger%22%2C%22lastName%22%3A%22Schulz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heinz-Erich%22%2C%22lastName%22%3A%22Wichmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Korbinian%22%2C%22lastName%22%3A%22Weigl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Efrat%22%2C%22lastName%22%3A%22Amitay%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Gottschick%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Asthma%20bronchiale%20stellt%20%5Cu00fcber%20alle%20Bildungsschichten%20hinweg%20eine%20der%20h%5Cu00e4ufigsten%20chronischen%20Erkrankungen%20im%20Kindes-%20und%20Erwachsenenalter%20dar.%20Im%20Erwachsenenalter%20erstmals%20auftretendes%20Asthma%20%28Adult-onset%20Asthma%2C%20AOA%29%20ist%20im%20Vergleich%20zu%20Childhood-onset%20Asthma%20%28COA%29%20mit%20einer%20schlechteren%20Prognose%20assoziiert%2C%20was%20verst%5Cu00e4rkte%20Untersuchungen%20in%20diesem%20Bereich%20erfordert.%20Ziel%20der%20Arbeit%20war%20es%2C%20H%5Cu00e4ufigkeiten%20und%20das%20Alter%20bei%20Erstdiagnose%20aus%20Selbstangaben%20zu%20Asthma%20bei%20Erwachsenen%20in%20der%20NAKO%20Gesundheitsstudie%20darzustellen%20und%20mit%20Daten%20der%20Studie%20zur%20Gesundheit%20Erwachsener%20in%20Deutschland%20%28DEGS%29%20zu%20vergleichen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Unsere%20Analyse%20beruht%20auf%20einem%20Datensatz%20zur%20Halbzeit%20der%20NAKO-Basiserhebung%20mit%20101.284%20Personen.%20Verwendete%20Variablen%20waren%20die%20Selbstangabe%20zum%20jemals%20%5Cu00e4rztlich%20diagnostizierten%20Asthma%2C%20Alter%20bei%20Erstdiagnose%2C%20Behandlung%20in%20den%20letzten%2012%5Cu00a0Monaten%2C%20Alter%20und%20Geschlecht.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Laut%20Datenbasis%20zur%20Halbzeit%20berichteten%20in%20der%20NAKO%208%2C7%5Cu202f%25%20der%20Frauen%20und%207%2C0%5Cu202f%25%20der%20M%5Cu00e4nner%2C%20dass%20bei%20ihnen%20jemals%20Asthma%20diagnostiziert%20wurde.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Etwa%20bei%20einem%20Drittel%20der%20Teilnehmenden%20mit%20Asthma%20wurde%20die%20Diagnose%20bereits%20im%20Kindes%5Cu2011%5C%2FJugendalter%20%28%3C18%5Cu00a0Jahre%29%20gestellt.%20Dabei%20waren%202%2C2%5Cu202f%25%20der%20Frauen%20und%202%2C8%5Cu202f%25%20der%20M%5Cu00e4nner%20von%20COA%20betroffen%20und%206%2C5%5Cu202f%25%20der%20Frauen%20und%204%2C2%5Cu202f%25%20der%20M%5Cu00e4nner%20von%20AOA.%20In%20den%20vorangegangenen%2012%5Cu00a0Monaten%20gaben%2033%5Cu202f%25%20der%20COA-F%5Cu00e4lle%20und%2060%5Cu202f%25%20der%20AOA-F%5Cu00e4lle%20an%2C%20%5Cu00e4rztlich%20behandelt%20worden%20zu%20sein.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20H%5Cu00e4ufigkeit%20von%20Asthma%20in%20der%20NAKO%20Gesundheitsstudie%20in%20Abh%5Cu00e4ngigkeit%20von%20Alter%20und%20Geschlecht%20entspricht%20weitgehend%20den%20Daten%20aus%20anderen%20Studien%20wie%20DEGS.%20Allerdings%20ist%20der%20AOA-Anteil%20h%5Cu00f6her%20als%20in%20der%20Literatur%20beschrieben.%20Der%20Anstieg%20der%20kumulativen%20Asthmadiagnosen%20ist%20bei%20den%20j%5Cu00fcngeren%20Geburtsjahrg%5Cu00e4ngen%20deutlich%20steiler%2C%20was%20f%5Cu00fcr%20eine%20Zunahme%20%5Cu00fcber%20die%20Zeit%20spricht.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Asthma%20is%20one%20of%20the%20most%20common%20chronic%20diseases%20in%20both%20children%20and%20adults.%20Asthma%20first%20occurring%20in%20adulthood%20%28adult-onset%20asthma%2C%20AOA%29%20is%20associated%20with%20poorer%20prognosis%20compared%20to%20childhood-onset%20asthma%20%28COA%29%2C%20which%20urgently%20calls%20for%20more%20research%20in%20this%20area.%20The%20aim%20of%20this%20work%20was%20to%20analyze%20the%20data%20on%20asthma%20collected%20in%20the%20German%20National%20Cohort%20and%20compare%20it%20with%20the%20German%20Health%20Interview%20and%20Examination%20Survey%20for%20Adults%20%28DEGS%29%2C%20in%20particular%20regarding%20AOA.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20and%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Our%20analysis%20was%20based%20on%20the%20dataset%20of%20the%20main%20questionnaire%20at%20mid-term%20of%20the%20German%20National%20Cohort%20baseline%20examination%2C%20comprising%20101%2C723%20participants.%20Variables%20considered%20in%20the%20analyses%20were%20self-reported%20diagnosis%20of%20asthma%2C%20age%20at%20first%20diagnosis%2C%20asthma%20treatment%20in%20the%20past%2012%5Cu00a0months%2C%20age%2C%20and%20sex.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20midterm%20dataset%2C%208.7%25%20of%20women%20and%207.0%25%20of%20men%20in%20the%20German%20National%20Cohort%20reported%20that%20they%20had%20ever%20been%20diagnosed%20with%20asthma.%20Approximately%20one%20third%20of%20participants%20with%20asthma%20received%20their%20initial%20diagnosis%20before%20their%2018th%20birthday.%20COA%20affected%202.2%25%20of%20women%20and%202.8%25%20of%20men%2C%20whereas%20AOA%20affected%206.5%25%20of%20women%20and%204.2%25%20of%20men.%20During%20the%20previous%2012%5Cu00a0months%2C%2033%25%20of%20COA%20cases%20and%2060%25%20of%20AOA%20cases%20were%20medically%20treated.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20proportion%20of%20persons%20affected%20by%20asthma%20in%20the%20German%20National%20Cohort%2C%20as%20well%20as%20observed%20patterns%20regarding%20age%20and%20gender%2C%20corresponds%20to%20other%20data%20sources%20such%20as%20DEGS.%20However%2C%20in%20our%20analysis%2C%20the%20proportion%20of%20individuals%20with%20AOA%20was%20higher%20than%20described%20in%20the%20literature.%20The%20increase%20in%20cumulative%20asthma%20diagnoses%20with%20age%20is%20markedly%20steeper%20in%20younger%20participants%2C%20indicating%20a%20rising%20trend%20over%20time.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03105-y%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03105-y%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A11%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22HULZN7CQ%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Leitzmann%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELeitzmann%20M%2C%20Gastell%20S%2C%20Hillreiner%20A%2C%20et%20al.%20K%26%23xF6%3Brperliche%20Aktivit%26%23xE4%3Bt%20in%20der%20NAKO%20Gesundheitsstudie%3A%20erste%20Ergebnisse%20des%20multimodalen%20Erhebungskonzepts.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A301-311.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03099-7%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03099-7%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22K%5Cu00f6rperliche%20Aktivit%5Cu00e4t%20in%20der%20NAKO%20Gesundheitsstudie%3A%20erste%20Ergebnisse%20des%20multimodalen%20Erhebungskonzepts%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Hillreiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Herbolsheimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%20E.%22%2C%22lastName%22%3A%22Baumeister%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Bohn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirko%22%2C%22lastName%22%3A%22Brandes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Schmermund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ole%22%2C%22lastName%22%3A%22Sprengeler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Zschocke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hansj%5Cu00f6rg%22%2C%22lastName%22%3A%22Baurecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Kalinowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilka%22%2C%22lastName%22%3A%22Ratjen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Steindorf%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03099-7%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03099-7%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A55Z%22%7D%7D%2C%7B%22key%22%3A%22GJLXMMST%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lieb%20and%20Vasan%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELieb%20W%2C%20Vasan%20RS.%20An%20update%20on%20genetic%20risk%20scores%20for%20coronary%20artery%20disease%3A%20are%20they%20useful%20for%20predicting%20disease%20risk%20and%20guiding%20clinical%20decisions%3F%20%3Ci%3EExpert%20Review%20of%20Cardiovascular%20Therapy%3C%5C%2Fi%3E.%202020%3B18%288%29%3A443-447.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F14779072.2020.1797489%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1080%5C%2F14779072.2020.1797489%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22An%20update%20on%20genetic%20risk%20scores%20for%20coronary%20artery%20disease%3A%20are%20they%20useful%20for%20predicting%20disease%20risk%20and%20guiding%20clinical%20decisions%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ramachandran%20S.%22%2C%22lastName%22%3A%22Vasan%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1080%5C%2F14779072.2020.1797489%22%2C%22ISSN%22%3A%221477-9072%2C%201744-8344%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.tandfonline.com%5C%2Fdoi%5C%2Ffull%5C%2F10.1080%5C%2F14779072.2020.1797489%22%2C%22collections%22%3A%5B%22XM47USVS%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A46Z%22%7D%7D%2C%7B%22key%22%3A%2234SUHIDU%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nimptsch%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ENimptsch%20K%2C%20Jaeschke%20L%2C%20Chang-Claude%20J%2C%20et%20al.%20Selbstberichtete%20Krebserkrankungen%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Erfassungsmethoden%20und%20erste%20Ergebnisse.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A385-396.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03113-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03113-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Selbstberichtete%20Krebserkrankungen%20in%20der%20NAKO%20Gesundheitsstudie%3A%20Erfassungsmethoden%20und%20erste%20Ergebnisse%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katharina%22%2C%22lastName%22%3A%22Nimptsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jenny%22%2C%22lastName%22%3A%22Chang-Claude%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Verena%22%2C%22lastName%22%3A%22Katzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Schmidt-Pokrzywniak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20der%20NAKO%20Gesundheitsstudie%20liegen%20die%20Daten%20zu%20selbstberichteten%20Krebserkrankungen%20der%20ersten%20H%5Cu00e4lfte%20der%20Teilnehmenden%20vor.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Beschreibung%20der%20Methoden%20zur%20Erfassung%20selbstberichteter%20Krebserkrankungen%20und%20Tumorlokalisationen%20in%20der%20NAKO%20und%20Darstellung%20erster%20Ergebnisse.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20einem%20computergest%5Cu00fctzten%2C%20standardisierten%20pers%5Cu00f6nlichen%20Interview%20wurden%20101.787%20Teilnehmende%20%2854.526%20Frauen%2C%2047.261%20M%5Cu00e4nner%29%20gefragt%2C%20ob%20bei%20ihnen%20jemals%20eine%20Krebserkrankung%20%28b%5Cu00f6sartiger%20Tumor%20einschlie%5Cu00dflich%20in%20situ%29%20%5Cu00e4rztlich%20diagnostiziert%20wurde%20und%20wie%20viele%20Krebserkrankungen%20sie%20hatten.%20Anhand%20einer%20Liste%20wurde%20die%20Tumorlokalisation%20erfragt.%20Absolute%20und%20relative%20H%5Cu00e4ufigkeiten%20von%20Selbstangaben%20zu%20Krebserkrankungen%20insgesamt%20und%20einzelnen%20Tumorlokalisationen%20wurden%20berechnet%20und%20mit%20krebsregisterbasierten%20Daten%20verglichen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Eine%20%5Cu00e4rztlich%20diagnostizierte%20Krebserkrankung%20wurde%20von%209%2C4%5Cu202f%25%20der%20Frauen%20und%207%2C0%5Cu202f%25%20der%20M%5Cu00e4nner%20berichtet.%20Von%20den%20Personen%2C%20die%20eine%20Krebserkrankung%20berichteten%2C%20gaben%2088%2C3%5Cu202f%25%20der%20Teilnehmenden%20an%2C%20nur%20eine%20Krebserkrankung%20gehabt%20zu%20haben.%20Bei%20Frauen%20war%20die%20h%5Cu00e4ufigste%20b%5Cu00f6sartige%20Krebserkrankung%20Brustkrebs%2C%20gefolgt%20von%20Geb%5Cu00e4rmutterhalskrebs%20und%20malignem%20Melanom%2C%20bei%20M%5Cu00e4nnern%20Prostatakrebs%2C%20gefolgt%20von%20malignem%20Melanom%20und%20Darmkrebs.%20Beim%20Vergleich%20der%20Krebserkrankungen%2C%20die%20von%2045-%20bis%2074-j%5Cu00e4hrigen%20NAKO-Teilnehmenden%20in%20den%20letzten%20f%5Cu00fcnf%20Jahren%20berichtet%20wurden%2C%20mit%20krebsregisterbasierten%205%5Cu2011Jahres-Pr%5Cu00e4valenzen%20wurden%20f%5Cu00fcr%20die%20meisten%20Tumorlokalisationen%20in%20der%20NAKO%20niedrigere%20relative%20H%5Cu00e4ufigkeiten%20beobachtet.%20Vergleichsweise%20h%5Cu00e4ufiger%20traten%20das%20maligne%20Melanom%20sowie%20Geb%5Cu00e4rmutterhalskrebs%20und%20Leberkrebs%20bei%20Frauen%20und%20Harnblasenkrebs%20und%20Brustkrebs%20bei%20M%5Cu00e4nnern%20auf.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20NAKO%20ist%20eine%20reichhaltige%20Datenbasis%20f%5Cu00fcr%20die%20zuk%5Cu00fcnftige%20Untersuchung%20inzidenter%20Krebserkrankungen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20the%20German%20National%20Cohort%20%28NAKO%20Gesundheitsstudie%29%2C%20the%20largest%20prospective%20cohort%20study%20in%20Germany%2C%20data%20on%20self-reported%20cancer%20diagnoses%20are%20now%20available%20for%20the%20first%20half%20of%20participants.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Description%20of%20the%20methods%20to%20assess%20self-reported%20cancer%20diagnoses%20and%20type%20of%20cancer%20in%20the%20NAKO%20and%20presentation%20of%20first%20results.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20a%5Cu00a0computer-assisted%2C%20standardized%20personal%20interview%2C%20101%2C787%20participants%20%2854%2C526%20women%2C%2047%2C261%20men%29%20were%20asked%20whether%20they%20had%20ever%20been%20diagnosed%20with%20cancer%20%28malignant%20tumors%20including%20in%20situ%29%20by%20a%5Cu00a0physician%20and%20how%20many%20cancer%20diagnoses%20they%20had.%20The%20type%20of%20cancer%20was%20classified%20with%20a%5Cu00a0list.%20Absolute%20and%20relative%20frequencies%20of%20self-reported%20cancer%20diagnoses%20and%20types%20of%20cancer%20were%20calculated%20and%20compared%20with%20cancer%20registry%20data.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20A%5Cu00a0physician-diagnosed%20cancer%20was%20reported%20by%209.4%25%20of%20women%20and%207.0%25%20of%20men.%20Of%20the%20participants%20who%20reported%20a%5Cu00a0cancer%20diagnosis%2C%2088.3%25%20reported%20to%20have%20had%20only%20one%20cancer%20diagnosis.%20In%20women%2C%20the%20most%20frequent%20malignancies%20were%20breast%20cancer%2C%20cervical%20cancer%2C%20and%20melanoma.%20In%20men%2C%20the%20most%20frequent%20malignancies%20were%20prostate%20cancer%2C%20melanoma%2C%20and%20colorectal%20cancer.%20Comparing%20the%20frequencies%20of%20cancer%20diagnoses%20reported%20by%2045-%5Cu00a0to%2074-year-old%20NAKO%20participants%20within%20the%20last%20five%5Cu00a0years%20to%20cancer%20registry-based%205%5Cu2011year%20prevalences%2C%20most%20types%20of%20cancer%20were%20less%20frequent%20in%20the%20NAKO%2C%20with%20the%20exception%20of%20melanoma%20in%20men%20and%20women%2C%20cervical%20cancer%20and%20liver%20cancer%20in%20women%2C%20and%20bladder%20cancer%20and%20breast%20cancer%20in%20men.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20NAKO%20is%20a%5Cu00a0rich%20data%20basis%20for%20future%20investigations%20of%20incident%20cancer.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03113-y%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03113-y%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A38Z%22%7D%7D%2C%7B%22key%22%3A%22NJGERSNF%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rach%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERach%20S%2C%20G%26%23xFC%3Bnther%20K%2C%20Hadeler%20B.%20Participants%20who%20were%20difficult%20to%20recruit%20at%20baseline%20are%20less%20likely%20to%20complete%20a%20follow-up%20questionnaire%20%26%23x2013%3B%20results%20from%20the%20German%20National%20Cohort.%20%3Ci%3EBMC%20Med%20Res%20Methodol%3C%5C%2Fi%3E.%202020%3B20%281%29%3A187.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12874-020-01073-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12874-020-01073-0%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Participants%20who%20were%20difficult%20to%20recruit%20at%20baseline%20are%20less%20likely%20to%20complete%20a%20follow-up%20questionnaire%20%5Cu2013%20results%20from%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Birte%22%2C%22lastName%22%3A%22Hadeler%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20With%20declining%20response%20proportions%20in%20population-based%20research%20the%20importance%20of%20evaluating%20the%20effectiveness%20of%20measures%20aimed%20at%20improving%20response%20increases.%20We%20investigated%20whether%20an%20additional%20flyer%20with%20information%20about%20the%20study%20influences%20participation%20in%20a%20follow-up%20questionnaire%20and%20the%20time%20participants%20take%20to%20send%20back%20filled%20questionnaire.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20a%20trial%20embedded%20within%20the%20German%20National%20Cohort%20we%20compared%20responses%20to%20invitations%20for%20a%20follow-up%20questionnaire%20either%20including%20a%20flyer%20with%20information%20about%20the%20cohort%20study%20or%20not%20including%20it.%20Outcomes%20of%20interest%20were%20participation%20in%20the%20follow-up%20%28yes%20vs.%20no%29%20and%20time%20to%20response%20%28in%20days%29.%20We%20analyzed%20paradata%20from%20baseline%20recruitment%20to%20account%20for%20differences%20in%20recruitment%20history%20between%20participants.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Adding%20a%20flyer%20to%20invitations%20did%20neither%20influence%20the%20likelihood%20of%20participation%20in%20the%20follow-up%20%28OR%200.94%2C%2095%25%20CI%3A%200.80%2C%201.11%29%2C%20nor%20the%20time%20it%20took%20participants%20to%20return%20completed%20questionnaires%20%28%5Cu03b2%5Cu0302%20%3D%201.71%2C%2095%25%20CI%3A%20%5Cu2212%5Cu20091.01%2C%204.44%29.%20Subjects%20who%2C%20at%20baseline%2C%20needed%20to%20be%20reminded%20before%20eventually%20participating%20in%20examinations%20and%20subjects%20who%20scheduled%20three%20or%20more%20appointments%20until%20eventually%20completing%20baseline%20examinations%20were%20less%20likely%20to%20complete%20the%20follow-up%20questionnaire%20and%2C%20if%20they%20did%2C%20took%20more%20time%20to%20complete%20questionnaires.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Evaluating%20the%20effectiveness%20of%20measures%20aimed%20at%20increasing%20response%20can%20help%20to%20improve%20the%20allocation%20of%20usually%20limited%20resources.%20Characteristics%20of%20baseline%20recruitment%20can%20influence%20response%20to%20follow-up%20studies%20and%20therefore%20information%20about%20recruitment%20history%20%28i.e.%2C%20paradata%29%20might%20prove%20useful%20to%20tailor%20follow-up%20recruitments%20to%20those%20who%20were%20difficult%20to%20recruit%20during%20baseline.%20To%20this%20end%2C%20however%2C%20it%20is%20necessary%20to%20routinely%20and%20meticulously%20collect%20paradata%20during%20recruitment.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12874-020-01073-0%22%2C%22ISSN%22%3A%221471-2288%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcmedresmethodol.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12874-020-01073-0%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A26Z%22%7D%7D%2C%7B%22key%22%3A%226942BCJF%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schikowski%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchikowski%20T%2C%20Wigmann%20C%2C%20Fuks%20KB%2C%20et%20al.%20Blutdruckmessung%20in%20der%20NAKO%20%26%23x2013%3B%20methodische%20Unterschiede%2C%20Blutdruckverteilung%20und%20Bekanntheit%20der%20Hypertonie%20im%20Vergleich%20zu%20anderen%20bev%26%23xF6%3Blkerungsbezogenen%20Studien%20in%20Deutschland.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A452-464.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03109-8%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03109-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Blutdruckmessung%20in%20der%20NAKO%20%5Cu2013%20methodische%20Unterschiede%2C%20Blutdruckverteilung%20und%20Bekanntheit%20der%20Hypertonie%20im%20Vergleich%20zu%20anderen%20bev%5Cu00f6lkerungsbezogenen%20Studien%20in%20Deutschland%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Wigmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kateryna%20B.%22%2C%22lastName%22%3A%22Fuks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Margit%22%2C%22lastName%22%3A%22Heier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannelore%22%2C%22lastName%22%3A%22Neuhauser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giselle%22%2C%22lastName%22%3A%22Sarganas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22D%5Cu00f6rr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ljupcho%22%2C%22lastName%22%3A%22Efremov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephan%20B.%22%2C%22lastName%22%3A%22Felix%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Haerting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Till%22%2C%22lastName%22%3A%22Ittermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolphe%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Kalinowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Moebus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Nuding%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ina-Maria%22%2C%22lastName%22%3A%22R%5Cu00fcckert-Eheberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Sch%5Cu00f6ttker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20Oliver%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inke%22%2C%22lastName%22%3A%22Thiele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barbara%22%2C%22lastName%22%3A%22Thorand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl%22%2C%22lastName%22%3A%22Werdan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03109-8%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03109-8%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22KA53FJLT%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wiessner%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWiessner%20C%2C%20Keil%20T%2C%20Krist%20L%2C%20et%20al.%20Personen%20mit%20Migrationshintergrund%20in%20der%20NAKO%20Gesundheitsstudie%20%26%23x2013%3B%20soziodemografische%20Merkmale%20und%20Vergleiche%20mit%20der%20autochthonen%20deutschen%20Bev%26%23xF6%3Blkerung.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A279-289.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03097-9%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03097-9%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Personen%20mit%20Migrationshintergrund%20in%20der%20NAKO%20Gesundheitsstudie%20%5Cu2013%20soziodemografische%20Merkmale%20und%20Vergleiche%20mit%20der%20autochthonen%20deutschen%20Bev%5Cu00f6lkerung%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wiessner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amand%22%2C%22lastName%22%3A%22F%5Cu00fchrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Guo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carmen%22%2C%22lastName%22%3A%22Jochem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Koch-Gallenkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Schmoor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sara%22%2C%22lastName%22%3A%22Schramm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Sowarka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Wigmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%20N.%22%2C%22lastName%22%3A%22Willich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Personen%20mit%20Migrationshintergrund%20%28PmM%29%20unterscheiden%20sich%20als%20Bev%5Cu00f6lkerungsgruppe%20hinsichtlich%20Morbidit%5Cu00e4t%2C%20Mortalit%5Cu00e4t%20und%20Inanspruchnahme%20des%20Gesundheitssystems%20meist%20von%20der%20autochthonen%20Bev%5Cu00f6lkerung%2C%20sie%20nehmen%20jedoch%20seltener%20an%20Gesundheitsstudien%20teil.%20Die%20Gruppe%20der%20PmM%20ist%20sehr%20heterogen%2C%20was%20in%20Studien%20bisher%20kaum%20ber%5Cu00fccksichtigt%20wird.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20der%20Arbeit%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Es%20werden%20soziodemografische%20Charakteristika%20der%20PmM%20in%20der%20NAKO%20Gesundheitsstudie%20%28Alter%2C%20Geschlecht%2C%20Zeit%20seit%20Migration%2C%20Bildung%29%20dargestellt.%20Zudem%20wird%20exemplarisch%20untersucht%2C%20ob%20der%20Migrationshintergrund%20mit%20der%20Nutzung%20des%20Angebots%20zur%20Fr%5Cu00fcherkennung%20von%20Darmkrebs%20%28H%5Cu00e4moccult-Test%29%20zusammenh%5Cu00e4ngt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Daten%20der%20ersten%20101.816%20Teilnehmenden%20der%20NAKO%20wurden%20deskriptiv%20und%20kartografisch%20ausgewertet.%20Die%20Zuweisung%20des%20Migrationshintergrunds%20erfolgte%20anhand%20der%20Definition%20des%20Statistischen%20Bundesamts%20und%20basiert%20auf%20Staatsangeh%5Cu00f6rigkeit%2C%20Geburtsland%2C%20Einreisejahr%20und%20Geburtsland%20der%20Eltern.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Der%20Anteil%20der%20PmM%20liegt%20bei%2016%2C0%5Cu202f%25.%20Die%20Verteilung%20%5Cu00fcber%20die%2018%5Cu00a0Studienzentren%20variiert%20zwischen%206%5Cu202f%25%20%28Neubrandenburg%29%20und%2033%5Cu202f%25%20%28D%5Cu00fcsseldorf%29.%20Mit%20153%20Herkunftsl%5Cu00e4ndern%20sind%20in%20der%20NAKO%20die%20meisten%20L%5Cu00e4nder%20vertreten.%20Bei%20allen%20Variablen%20zeigen%20sich%20deutliche%20Unterschiede%20zwischen%20den%20verschiedenen%20Herkunftsregionen.%20Am%20H%5Cu00e4moccult-Test%20nehmen%20t%5Cu00fcrkeist%5Cu00e4mmige%20Personen%20%28OR%5Cu202f%3D%5Cu20090%2C67%29%20und%20Aussiedler%20aus%20der%20ehemaligen%20Sowjetunion%20%28OR%5Cu202f%3D%5Cu20090%2C60%29%20seltener%20teil.%20PmM%2C%20die%20in%20Deutschland%20geboren%20sind%2C%20unterscheiden%20sich%20diesbez%5Cu00fcglich%20nicht%20von%20der%20autochthonen%20Bev%5Cu00f6lkerung%20%28OR%5Cu202f%3D%5Cu20090%2C99%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20PmM%20in%20der%20NAKO%20sind%20eine%20sehr%20heterogene%20Gruppe.%20Jedoch%20lassen%20sich%20aufgrund%20der%20Stichprobengr%5Cu00f6%5Cu00dfe%20einzelne%20Untergruppen%20der%20PmM%20hinsichtlich%20ihrer%20Herkunftsregion%20separat%20untersuchen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Persons%20with%20a%5Cu00a0migration%20background%20%28PmM%29%20as%20a%5Cu00a0population%20group%20usually%20differ%20from%20the%20autochthonous%20population%20in%20terms%20of%20morbidity%2C%20mortality%2C%20and%20use%20of%20the%20health%20care%20system%2C%20but%20they%20participate%20less%20frequently%20in%20health%20studies.%20The%20PmM%20group%20is%20very%20heterogeneous%2C%20which%20has%20hardly%20been%20taken%20into%20account%20in%20studies%20so%20far.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Sociodemographic%20characteristics%20of%20PmM%20in%20the%20NAKO%20health%20study%20%28age%2C%20sex%2C%20time%20since%20migration%2C%20education%29%20are%20presented.%20In%20addition%2C%20it%20is%20examined%20through%20an%20example%20whether%20migration%20background%20is%20related%20to%20the%20use%20of%20cancer%20screening%20for%20colorectal%20cancer%20%28hemoccult%20test%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20of%20the%20first%20101%2C816%20persons%20of%20the%20NAKO%20were%20analyzed%20descriptively%20and%20cartographically.%20The%20migration%20background%20was%20assigned%20on%20the%20basis%20of%20the%20definition%20of%20the%20Federal%20Statistical%20Office%2C%20based%20on%20nationality%2C%20country%20of%20birth%2C%20year%20of%20entry%2C%20and%20country%20of%20birth%20of%20the%20parents.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Overall%2C%20the%20PmM%20proportion%20is%2016.0%25.%20The%20distribution%20across%20the%2018%5Cu00a0study%20centers%20varies%20considerably%20between%206%25%20%28Neubrandenburg%29%20and%2033%25%20%28D%5Cu00fcsseldorf%29.%20With%20153%20countries%20of%20origin%2C%20most%20countries%20are%20represented%20in%20the%20NAKO.%20All%20variables%20show%20clear%20differences%20between%20the%20different%20regions%20of%20origin.%20In%20the%20hemoccult%20test%2C%20persons%20of%20Turkish%20origin%20%28OR%5Cu202f%3D%5Cu20090.67%29%20and%20resettlers%20%28OR%5Cu202f%3D%5Cu20090.60%29%20have%20a%5Cu00a0lower%20participation%20rate.%20PmM%20born%20in%20Germany%20do%20not%20differ%20in%20this%20respect%20from%20the%20autochthonous%20population%20%28OR%5Cu202f%3D%5Cu20090.99%29.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20PmM%20in%20the%20NAKO%20are%20a%5Cu00a0very%20heterogeneous%20group.%20However%2C%20due%20to%20the%20sample%20size%2C%20individual%20subgroups%20of%20migrants%20can%20be%20studied%20separately%20with%20respect%20to%20region%20of%20origin.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03097-9%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03097-9%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A10%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22MG2SAKNU%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Winter%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWinter%20T%2C%20Friedrich%20N%2C%20Lamp%20S%2C%20et%20al.%20The%20Integrated%20Research%20Biobank%20of%20the%20University%20Medicine%20Greifswald.%20%3Ci%3EOpen%20Journal%20of%20Bioresources%3C%5C%2Fi%3E.%202020%3B7%3A2.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5334%5C%2Fojb.64%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5334%5C%2Fojb.64%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Integrated%20Research%20Biobank%20of%20the%20University%20Medicine%20Greifswald%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Theresa%22%2C%22lastName%22%3A%22Winter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nele%22%2C%22lastName%22%3A%22Friedrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophia%22%2C%22lastName%22%3A%22Lamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Sch%5Cu00e4fer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mario%22%2C%22lastName%22%3A%22Schattschneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Bollmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Diana%22%2C%22lastName%22%3A%22Br%5Cu00fcmmer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katja%22%2C%22lastName%22%3A%22Riemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Petersmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Nauck%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.5334%5C%2Fojb.64%22%2C%22ISSN%22%3A%222056-5542%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fopenbioresources.metajnl.com%5C%2Farticles%5C%2F10.5334%5C%2Fojb.64%5C%2F%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A55Z%22%7D%7D%2C%7B%22key%22%3A%226JRE63BT%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wolf%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EWolf%20K%2C%20Kraus%20U%2C%20Dzolan%20M%2C%20et%20al.%20N%26%23xE4%3Bchtliche%20Verkehrsl%26%23xE4%3Brmbel%26%23xE4%3Bstigung%20in%20Deutschland%3A%20individuelle%20und%20regionale%20Unterschiede%20in%20der%20NAKO%20Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A332-343.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03094-y%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03094-y%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22N%5Cu00e4chtliche%20Verkehrsl%5Cu00e4rmbel%5Cu00e4stigung%20in%20Deutschland%3A%20individuelle%20und%20regionale%20Unterschiede%20in%20der%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Wolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ute%22%2C%22lastName%22%3A%22Kraus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mihovil%22%2C%22lastName%22%3A%22Dzolan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gabriele%22%2C%22lastName%22%3A%22Bolte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobia%22%2C%22lastName%22%3A%22Lakes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Moebus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Mueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Rathmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Inke%22%2C%22lastName%22%3A%22Thiele%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Thierry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Wigmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Zschocke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Schneider%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20L%5Cu00e4rmbel%5Cu00e4stigung%20geht%20mit%20gesundheitlicher%20Beeintr%5Cu00e4chtigung%20und%20reduziertem%20Wohlbefinden%20einher.%20Die%20subjektive%20L%5Cu00e4rmbel%5Cu00e4stigung%20steht%20im%20Zusammenhang%20mit%20der%20objektiven%20L%5Cu00e4rmbelastung%20sowie%20individuellen%20und%20regionalen%20Faktoren.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Fragestellung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Wie%20viele%20Teilnehmende%20der%20NAKO%20Gesundheitsstudie%20f%5Cu00fchlen%20sich%20durch%20n%5Cu00e4chtlichen%20Verkehrsl%5Cu00e4rm%20bel%5Cu00e4stigt%20und%20welche%20Faktoren%20stehen%20damit%20im%20Zusammenhang%3F%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diese%20Querschnittsanalyse%20basiert%20auf%20Daten%20von%2086.080%20NAKO-Teilnehmenden%20aus%2018%5Cu00a0Studienzentren%2C%20die%20von%202014%20bis%202017%20untersucht%20wurden.%20Um%20die%20Beziehungen%20zwischen%20individuellen%20und%20regionalen%20Faktoren%20und%20Verkehrsl%5Cu00e4rmbel%5Cu00e4stigung%20in%20den%20Kategorien%20nicht%20bel%5Cu00e4stigt%2C%20leicht%5C%2Fmittel%20und%20stark%5C%2Fsehr%20stark%20bel%5Cu00e4stigt%20zu%20untersuchen%2C%20wurden%20multinomiale%20logistische%20Regressionsmodelle%20mit%20wechselseitiger%20Adjustierung%20der%20Faktoren%20verwendet.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Zwei%20Drittel%20der%20Teilnehmenden%20f%5Cu00fchlten%20sich%20nicht%20durch%20Verkehrsl%5Cu00e4rm%20bel%5Cu00e4stigt%3B%20jeder%20Zehnte%20berichtete%20von%20starker%5C%2Fsehr%20starker%20Bel%5Cu00e4stigung%2C%20mit%20den%20h%5Cu00f6chsten%20Anteilen%20in%20Berlin-Mitte%20und%20Leipzig.%20Die%20st%5Cu00e4rksten%20Assoziationen%20mit%20L%5Cu00e4rmbel%5Cu00e4stigung%20wurden%20f%5Cu00fcr%20Faktoren%20der%20individuellen%20Wohnsituation%20beobachtet%2C%20wie%20z.%5Cu202fB.%20die%20Position%20des%20Schlafraums%20zur%20Hauptstra%5Cu00dfe%20%28OR%20f%5Cu00fcr%20leicht%5C%2Fmittel%20bel%5Cu00e4stigt%3A%204%2C26%20%5B95%5Cu202f%25%20KI%3A%204%2C01%3B%204%2C52%5D%3B%20OR%20f%5Cu00fcr%20stark%5C%2Fsehr%20stark%20bel%5Cu00e4stigt%3A%2013%2C36%20%5B95%5Cu202f%25%20KI%3A%2012%2C47%3B%2014%2C32%5D%20im%20Vergleich%20zu%20Garten%5C%2FInnenhof%29.%20Teilnehmende%20im%20Alter%20von%2040%5Cu201360%5Cu00a0Jahren%20oder%20der%20mittleren%20und%20niedrigen%20Einkommensklasse%20f%5Cu00fchlten%20sich%20eher%20durch%20Verkehrsl%5Cu00e4rm%20bel%5Cu00e4stigt%20als%20j%5Cu00fcngere%20bzw.%20%5Cu00e4ltere%20Teilnehmende%20oder%20solche%20mit%20hoher%20Einkommensklasse.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Teilnehmende%20der%20NAKO%20Gesundheitsstudie%20wiesen%20Unterschiede%20in%20der%20Bel%5Cu00e4stigung%20durch%20n%5Cu00e4chtlichen%20Verkehrsl%5Cu00e4rm%20in%20Bezug%20auf%20individuelle%20und%20regionale%20Faktoren%20auf.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Noise%20annoyance%20is%20associated%20with%20adverse%20health-related%20conditions%20and%20reduced%20wellbeing.%20Thereby%2C%20subjective%20noise%20annoyance%20depends%20on%20the%20objective%20noise%20exposure%20and%20is%20modified%20by%20personal%20and%20regional%20factors.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objective%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20How%20many%20participants%20of%20the%20German%20National%20Cohort%20Study%20%28GNC%3B%20NAKO%20Gesundheitsstudie%29%20were%20annoyed%20by%20transportation%20noise%20during%20nighttime%20and%20what%20factors%20were%20associated%20with%20noise%20annoyance%3F%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20This%20cross-sectional%20analysis%20included%2086%2C080%20participants%20from%2018%5Cu00a0study%20centers%2C%20examined%20from%202014%20to%202017.%20We%20used%20multinomial%20logistic%20regression%20to%20investigate%20associations%20of%20personal%20and%20regional%20factors%20to%20noise%20annoyance%20%28slightly%5C%2Fmoderately%20or%20strongly%5C%2Fextremely%20annoyed%20vs.%20not%20annoyed%29%20mutually%20adjusting%20for%20all%20factors%20in%20the%20model.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Two%20thirds%20of%20participants%20were%20not%20annoyed%20by%20transportation%20noise%20during%20nighttime%20and%20one%20in%20ten%20reported%20strong%5C%2Fextreme%20annoyance%20with%20highest%20percentages%20for%20the%20study%20centers%20Berlin-Mitte%20and%20Leipzig.%20The%20strongest%20associations%20were%20seen%20for%20factors%20related%20to%20the%20individual%20housing%20situation%20like%20the%20bedroom%20being%20positioned%20towards%20a%5Cu00a0major%20road%20%28OR%20of%20being%20slightly%5C%2Fmoderately%20annoyed%3A%204.26%20%5B95%25%20CI%3A%204.01%3B4.52%5D%3B%20OR%20of%20being%20strongly%5C%2Fextremely%20annoyed%3A%2013.36%20%5B95%25%20CI%3A%2012.47%3B14.32%5D%29%20compared%20to%20a%5Cu00a0garden%5C%2Finner%20courtyard.%20Participants%20aged%2040%5Cu201360%5Cu00a0years%20and%20those%20in%20low-%20and%20medium-income%20groups%20reported%20greater%20noise%20annoyance%20compared%20to%20younger%20or%20older%20ones%20and%20those%20in%20the%20high-income%20group.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20this%20study%20from%20Germany%2C%20transportation%20noise%20annoyance%20during%20nighttime%20varied%20by%20personal%20and%20regional%20factors.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03094-y%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03094-y%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-09-12T13%3A09%3A49Z%22%7D%7D%2C%7B%22key%22%3A%222CAH4P3V%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dragano%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EDragano%20N%2C%20Reuter%20M%2C%20Greiser%20KH%2C%20et%20al.%20Soziodemografische%20und%20erwerbsbezogene%20Merkmale%20in%20der%20NAKO%20Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A267-278.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03098-8%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03098-8%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Soziodemografische%20und%20erwerbsbezogene%20Merkmale%20in%20der%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marvin%22%2C%22lastName%22%3A%22Reuter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carina%22%2C%22lastName%22%3A%22Emmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Loeffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Lampert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20epidemiologischen%20Studien%20ist%20die%20standardisierte%20Erfassung%20soziodemografischer%20Merkmale%20von%20hoher%20Bedeutung%2C%20da%20Variablen%20wie%20Geschlecht%2C%20Alter%2C%20Bildung%20oder%20Erwerbsstatus%20wichtige%20Einflussfaktoren%20auf%20Gesundheitschancen%20und%20Krankheitsrisiken%20darstellen.%20In%20der%20NAKO%20Gesundheitsstudie%20werden%20zentrale%20Faktoren%20aus%20diesem%20Themenbereich%20ber%5Cu00fccksichtigt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20der%20Arbeit%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Der%20Beitrag%20gibt%20einen%20%5Cu00dcberblick%20%5Cu00fcber%20den%20wissenschaftlichen%20Hintergrund%20und%20die%20konkrete%20Erhebung%20soziodemografischer%20Angaben%20in%20der%20NAKO.%20Zudem%20werden%20die%20Verteilung%20einzelner%20Merkmale%20sowie%20Zusammenh%5Cu00e4nge%20mit%20gesundheitsassoziierten%20Ma%5Cu00dfen%20exemplarisch%20vorgestellt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20Anhand%20der%20Daten%20zur%20Halbzeit%20der%20Basiserhebung%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu2009101.724%29%20wurde%20die%20Verteilung%20soziodemografischer%20Merkmale%20dargestellt%20und%20Zusammenh%5Cu00e4nge%20mit%20beispielhaft%20ausgew%5Cu00e4hlten%20Gesundheitsindikatoren%20%28Body-Mass-Index%2C%20selbst%20berichtete%20Gesundheit%29%20analysiert%2C%20um%20die%20Validit%5Cu00e4t%20der%20Messung%20soziodemografischer%20Angaben%20zu%20beurteilen.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Das%20mittlere%20Alter%20der%20Teilnehmenden%20lag%20bei%2052%2C0%20Jahren%20%28SD%5Cu202f%3D%5Cu200912%2C4%29.%2053%2C6%5Cu202f%25%20der%20Teilnehmenden%20waren%20Frauen%2C%2054%2C3%5Cu202f%25%20hatten%20einen%20hohen%20Bildungsabschluss%2C%2060%2C1%5Cu202f%25%20waren%20verheiratet%20zusammenlebend%2C%2072%2C0%5Cu202f%25%20erwerbst%5Cu00e4tig%20und%203%2C4%5Cu202f%25%20erwerbslos.%20Bekannte%20Zusammenh%5Cu00e4nge%20zwischen%20Soziodemografie%20und%20Gesundheit%20konnten%20reproduziert%20werden.%20So%20waren%20niedrige%20Bildung%2C%20hohes%20Alter%20und%20Erwerbslosigkeit%20mit%20einer%20erh%5Cu00f6hten%20H%5Cu00e4ufigkeit%20von%20Adipositas%20und%20schlechter%20selbst%20berichteter%20Gesundheit%20assoziiert.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20NAKO%20Gesundheitsstudie%20erhebt%20viele%20soziodemografische%20Merkmale.%20In%20Kombination%20mit%20der%20F%5Cu00fclle%20an%20Gesundheitsdaten%20und%20dem%20L%5Cu00e4ngsschnittdesign%20ergeben%20sich%20so%20neue%20M%5Cu00f6glichkeiten%20f%5Cu00fcr%20die%20gesundheitswissenschaftliche%20und%20sozialepidemiologische%20Forschung%20in%20Deutschland.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20epidemiologic%20studies%2C%20standardised%20measurement%20of%20socio-demographic%20and%20employment-related%20factors%20is%20becoming%20increasingly%20important%2C%20as%20variables%20such%20as%20gender%2C%20age%2C%20education%20or%20employment%20status%20are%20factors%20influencing%20health%20and%20disease%20risks.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Aims%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20article%20gives%20an%20overview%20of%20the%20scientific%20background%20and%20assessment%20of%20socio-demographic%20factors%20in%20the%20German%20National%20Cohort%20Study.%20In%20addition%2C%20the%20distribution%20of%20individual%20characteristics%20in%20the%20cohort%20as%20well%20as%20relationships%20with%20health-related%20measures%20are%20presented%20by%20way%20of%20example.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20analysis%20is%20based%20on%20the%20data%20of%20the%20first%20half%20of%20the%20baseline%20survey%20%28%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20n%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu202f%3D%5Cu2009101%2C724%29.%20On%20this%20basis%2C%20we%20present%20the%20distribution%20of%20key%20socio-demographic%20characteristics%20and%20analyse%20relationships%20with%20exemplary%20selected%20health%20indicators%20%28body%20mass%20index%2C%20self-reported%20health%29%20to%20assess%20the%20validity%20of%20socio-demographic%20data%20measurements.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20On%20average%2C%20study%20participants%20were%2052.0%20years%20old%20%28SD%5Cu202f%3D%5Cu200912.4%29.%20Of%20the%20participants%2C%2053.6%25%20were%20women%2C%2054.3%25%20had%20high%20education%2C%2060.1%25%20were%20married%20and%2072%25%20were%20employed%20while%203.4%25%20were%20unemployed.%20Well-established%20correlations%20between%20socio-demographic%20factors%20and%20health%20could%20be%20reproduced%20with%20the%20German%20National%20Cohort%20data.%20For%20example%2C%20low%20education%2C%20old%20age%20and%20unemployment%20were%20associated%20with%20an%20increased%20prevalence%20of%20obesity%20and%20poor%20self-reported%20health.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20provides%20a%5Cu00a0comprehensive%20measurement%20of%20socio-demographic%20characteristics.%20Combined%20with%20a%5Cu00a0wide%20range%20of%20health%20data%20and%20the%20longitudinal%20measurements%20available%20in%20the%20future%2C%20this%20opens%20up%20new%20opportunities%20for%20health%20science%20and%20social%20epidemiological%20research%20in%20Germany.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03098-8%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03098-8%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-15T16%3A35%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22NS4JCWF4%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ahrens%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAhrens%20W%2C%20Pigeot%20I%2C%20Pischon%20T.%20Das%20Fundament%20ist%20gelegt%20%26%23x2013%3B%20f%26%23xFC%3Br%20verbesserte%20Vorbeugung%20und%20Fr%26%23xFC%3Bherkennung%20der%20gro%26%23xDF%3Ben%20Volkskrankheiten.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A373-375.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03119-6%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03119-6%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Das%20Fundament%20ist%20gelegt%20%5Cu2013%20f%5Cu00fcr%20verbesserte%20Vorbeugung%20und%20Fr%5Cu00fcherkennung%20der%20gro%5Cu00dfen%20Volkskrankheiten%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Pigeot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03119-6%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03119-6%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-08-15T14%3A02%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22Q4ZSPK6Y%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ahrens%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAhrens%20W%2C%20Pigeot%20I%2C%20Pischon%20T.%20Was%20macht%20krank%2C%20was%20h%26%23xE4%3Blt%20uns%20gesund%3F%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A251-253.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03104-z%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03104-z%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Was%20macht%20krank%2C%20was%20h%5Cu00e4lt%20uns%20gesund%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Pigeot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03104-z%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03104-z%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-08-15T14%3A02%3A28Z%22%7D%7D%2C%7B%22key%22%3A%224C8V3XG5%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ahrens%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAhrens%20W%2C%20Greiser%20KH%2C%20Linseisen%20J%2C%20Pischon%20T%2C%20Pigeot%20I.%20Erforschung%20von%20Erkrankungen%20in%20der%20NAKO%20Gesundheitsstudie.%20Die%20wichtigsten%20gesundheitlichen%20Endpunkte%20und%20ihre%20Erfassung.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A376-384.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03111-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03111-0%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Erforschung%20von%20Erkrankungen%20in%20der%20NAKO%20Gesundheitsstudie.%20Die%20wichtigsten%20gesundheitlichen%20Endpunkte%20und%20ihre%20Erfassung%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20H.%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Pigeot%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Im%20Mittelpunkt%20der%20NAKO%20Gesundheitsstudie%2C%20der%20bislang%20gr%5Cu00f6%5Cu00dften%20populationsbezogenen%20Kohortenstudie%20in%20Deutschland%2C%20steht%20die%20Erforschung%20von%20typischen%20Volkskrankheiten%20wie%20Herz-Kreislauf-Erkrankungen%2C%20Diabetes%2C%20Krebs%2C%20neurologischen%20und%20psychiatrischen%20Erkrankungen%20sowie%20h%5Cu00e4ufigen%20Atemwegs-%20und%20Infektionserkrankungen.%20Anhand%20dieser%20Kohorte%20sollen%20Fragen%20zum%20Einfluss%20von%20Faktoren%2C%20wie%20z.%5Cu202fB.%20Genen%2C%20Umwelteinfl%5Cu00fcssen%20und%20Lebensstil%2C%20auf%20die%20Krankheitsentstehung%20beantwortet%20werden.%20Ein%20weiterer%20Fokus%20richtet%20sich%20auf%20die%20fr%5Cu00fchzeitige%20Erkennung%20von%20sich%20anbahnenden%20Erkrankungen%20anhand%20subklinischer%20Marker.%20Dazu%20muss%20ein%20umfassendes%20Bild%20der%20gesundheitlichen%20Endpunkte%2C%20aber%20auch%20aller%20m%5Cu00f6glichen%20Expositionen%20gewonnen%20werden.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Dieser%20Beitrag%20konzentriert%20sich%20auf%20die%20Beschreibung%20der%20verschiedenen%20gesundheitlichen%20Endpunkte%2C%20die%20in%20der%20NAKO%20Gesundheitsstudie%20erfasst%20werden%2C%20und%20der%20Untersuchungsmodule%2C%20die%20zur%20tiefgehenden%20Ph%5Cu00e4notypisierung%20der%20Studienteilnehmerinnen%20und%20-teilnehmer%20eingesetzt%20werden.%20Durch%20die%20wiederholte%20Gewinnung%20von%20Bioproben%20und%20die%20Durchf%5Cu00fchrung%20funktioneller%20Messungen%20sowie%20moderner%20bildgebender%20Verfahren%20zu%20verschiedenen%20Zeitpunkten%20l%5Cu00e4sst%20sich%20insbesondere%20die%20Dynamik%20physiologischer%20Ver%5Cu00e4nderungen%20des%20individuellen%20Gesundheitszustands%20abbilden%20und%20der%20prognostische%20Wert%20dieser%20Ver%5Cu00e4nderungen%20f%5Cu00fcr%20die%20Krankheitsentstehung%20untersuchen%3B%20die%20daraus%20gewonnenen%20Erkenntnisse%20k%5Cu00f6nnen%20die%20Basis%20f%5Cu00fcr%20neuartige%20Pr%5Cu00e4ventionsans%5Cu00e4tze%20und%20die%20Weiterentwicklung%20personalisierter%20Medizin%20bilden.%20Neu%20auftretende%20Erkrankungen%20werden%20sowohl%20%5Cu00fcber%20Selbstangaben%20der%20Studienteilnehmer%20als%20auch%20%5Cu00fcber%20die%20Verkn%5Cu00fcpfung%20mit%20Krankenkassen-%20und%20Krebsregisterdaten%20erfasst.%20Um%20eine%20hohe%20Qualit%5Cu00e4t%20der%20so%20erhobenen%20Diagnosen%20zu%20erreichen%2C%20werden%20zus%5Cu00e4tzlich%20Informationen%20von%20behandelnden%20%5Cu00c4rzten%20eingeholt.%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20The%20focus%20of%20the%20German%20National%20Cohort%2C%20the%20largest%20population-based%20cohort%20study%20in%20Germany%20to%20date%2C%20is%20the%20investigation%20of%20the%20most%20important%20widespread%20diseases%2C%20such%20as%20cardiovascular%20diseases%2C%20diabetes%2C%20cancer%2C%20neurological%20and%20psychiatric%20disorders%2C%20and%20frequent%20respiratory%20and%20infectious%20diseases.%20This%20cohort%20will%20answer%20questions%20on%20the%20development%20of%20these%20diseases%20and%20on%20the%20impact%20of%20genetic%2C%20environmental%20and%20lifestyle-related%20risk%20factors.%20Another%20focus%20is%20on%20the%20identification%20of%20early%2C%20subclinical%20markers%20of%20emerging%20diseases.%20To%20answer%20these%20questions%2C%20a%5Cu00a0comprehensive%20assessment%20of%20these%20health%20outcomes%20as%20well%20as%20of%20all%20potential%20determinants%20and%20precursors%20is%20mandatory.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20This%20paper%20describes%20the%20various%20health%20outcomes%20that%20are%20assessed%20in%20the%20German%20National%20Cohort%2C%20as%20well%20as%20the%20examination%20modules%20that%20are%20applied%20for%20deep%20phenotyping%20of%20study%20participants.%20Repeated%20collection%20of%20biosamples%20as%20well%20as%20functional%20measurements%20and%20application%20of%20modern%20imaging%20techniques%20at%20various%20time%20points%20allow%20for%20assessing%20the%20dynamics%20of%20physiological%20changes%20related%20to%20the%20individuals%5Cu2019%20health%20status.%20The%20prognostic%20value%20of%20these%20changes%20for%20disease%20development%20will%20be%20explored%20and%20translated%20to%20novel%20approaches%20for%20prevention%20and%20personalised%20medicine.%20Incident%20diseases%20are%20being%20assessed%20through%20self-reports%20by%20study%20participants%20and%20through%20record%20linkage%20with%20data%20from%20health%20insurances%20and%20cancer%20registries.%20Additional%20information%20about%20clinical%20diagnoses%20is%20obtained%20from%20the%20treating%20physicians%20to%20ensure%20the%20highest%20possible%20validity.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03111-0%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03111-0%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-15T13%3A54%3A10Z%22%7D%7D%2C%7B%22key%22%3A%22ZJDDI3HG%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zeeb%20and%20Dreger%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EZeeb%20H%2C%20Dreger%20S.%20Medizinische%20Strahlenexposition%20in%20der%20NAKO%20Gesundheitsstudie%20-%20Vorhaben%203616S42233.%202020.%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoris.bfs.de%5C%2Fjspui%5C%2Fbitstream%5C%2Furn%3Anbn%3Ade%3A0221-2020050821816%5C%2F3%5C%2FBfS_2020_3616S42233.pdf%27%3Ehttp%3A%5C%2F%5C%2Fdoris.bfs.de%5C%2Fjspui%5C%2Fbitstream%5C%2Furn%3Anbn%3Ade%3A0221-2020050821816%5C%2F3%5C%2FBfS_2020_3616S42233.pdf%3C%5C%2Fa%3E.%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22document%22%2C%22title%22%3A%22Medizinische%20Strahlenexposition%20in%20der%20NAKO%20Gesundheitsstudie%20-%20Vorhaben%203616S42233%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hajo%22%2C%22lastName%22%3A%22Zeeb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steffen%22%2C%22lastName%22%3A%22Dreger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fdoris.bfs.de%5C%2Fjspui%5C%2Fbitstream%5C%2Furn%3Anbn%3Ade%3A0221-2020050821816%5C%2F3%5C%2FBfS_2020_3616S42233.pdf%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-08-07T11%3A09%3A20Z%22%7D%7D%2C%7B%22key%22%3A%223L6228LI%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schmidt%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchmidt%20CO%2C%20G%26%23xFC%3Bnther%20KP%2C%20Goronzy%20J%2C%20et%20al.%20H%26%23xE4%3Bufigkeiten%20muskuloskelettaler%20Symptome%20und%20Erkrankungen%20in%20der%20bev%26%23xF6%3Blkerungsbezogenen%20NAKO%20Gesundheitsstudie.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%284%29%3A415-425.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03110-1%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03110-1%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22H%5Cu00e4ufigkeiten%20muskuloskelettaler%20Symptome%20und%20Erkrankungen%20in%20der%20bev%5Cu00f6lkerungsbezogenen%20NAKO%20Gesundheitsstudie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20Oliver%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus-Peter%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%22%2C%22lastName%22%3A%22Goronzy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katinka%22%2C%22lastName%22%3A%22Albrecht%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Chenot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johanna%22%2C%22lastName%22%3A%22Callhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adrian%22%2C%22lastName%22%3A%22Richter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Kasch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%22%2C%22lastName%22%3A%22Jenning%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00e9rard%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christa%22%2C%22lastName%22%3A%22Meisinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christof%22%2C%22lastName%22%3A%22Specker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angela%22%2C%22lastName%22%3A%22Zink%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Sander%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Muskuloskelettale%20Symptome%20und%20Erkrankungen%20sind%20in%20der%20Bev%5Cu00f6lkerung%20sehr%20weit%20verbreitet%20und%20verursachen%20hohe%20Kosten%20in%20Gesundheitswesen%20und%20Volkswirtschaft.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ziel%20der%20Arbeit%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20H%5Cu00e4ufigkeit%20muskuloskelettaler%20Symptome%20und%20Erkrankungen%20aus%20den%20Bereichen%20R%5Cu00fcckenschmerzen%2C%20Osteoporose%2C%20Arthrose%20und%20Arthritis%20wurde%20auf%20Basis%20von%20Daten%20der%20bev%5Cu00f6lkerungsbasierten%20NAKO%20Gesundheitsstudie%20beschrieben.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Material%20und%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20Daten%20wurden%20in%20der%20ersten%20H%5Cu00e4lfte%20der%20NAKO-Basiserhebung%20von%20M%5Cu00e4rz%202014%20bis%20M%5Cu00e4rz%202017%20bei%20Erwachsenen%20im%20Alter%20von%2020%5Cu201375%5Cu00a0Jahren%20erhoben.%20In%20die%20Analysen%20gingen%20Daten%20von%20101.779%20Interviewteilnehmenden%20sowie%20von%209370%20Teilnehmenden%20aus%20zwei%20klinischen%20Untersuchungen%20ein.%20Mittels%20der%20klinischen%20Handuntersuchung%20wurden%20tastbar%20geschwollene%20Gelenke%20sowie%20auf%20Druck%20schmerzhafte%20Gelenke%20identifiziert.%20Die%20Winkelstuhluntersuchung%20lieferte%20Daten%20zu%20Ruheschmerzen%20am%20Knie-%20und%20H%5Cu00fcftgelenk.%20H%5Cu00e4ufigkeiten%20wurden%20auf%20die%20deutsche%20Standardbev%5Cu00f6lkerung%202011%20gewichtet.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20den%20Selbstberichten%20der%20Teilnehmenden%20im%20Interview%20wurden%20am%20h%5Cu00e4ufigsten%20jemals%20diagnostizierte%20andauernde%20R%5Cu00fcckenschmerzen%20%2822%2C5%5Cu202f%25%29%20und%20Arthrosen%20%2820%2C6%5Cu202f%25%29%20angegeben%2C%20seltener%20Osteoporose%20%282%2C9%5Cu202f%25%29%20und%20rheumatoide%20Arthritis%20%281%2C9%5Cu202f%25%29.%20In%20der%20Handuntersuchung%20wurden%20bei%206%2C0%5Cu202f%25%20Schmerzen%20an%20mindestens%20einem%20Fingergelenk%20festgestellt.%20Laut%20Winkelstuhluntersuchung%20waren%208%2C2%5Cu202f%25%20von%20einem%20Ruheschmerz%20in%20mindestens%20einem%20Knie%20betroffen%20sowie%205%2C1%5Cu202f%25%20an%20der%20H%5Cu00fcfte.%20Frauen%20berichteten%20insgesamt%20h%5Cu00e4ufiger%20muskuloskelettale%20Erkrankungen%20und%20Symptome%20als%20M%5Cu00e4nner%2C%20der%20Anteil%20Betroffener%20nahm%20mit%20dem%20Alter%20deutlich%20zu.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20Ergebnisse%20belegen%20die%20gro%5Cu00dfe%20Verbreitung%20vieler%20muskuloskelettaler%20Erkrankungen.%20Die%20berichtete%20Beschwerdelast%20ist%20mit%20Ergebnissen%20aus%20fr%5Cu00fcheren%20bev%5Cu00f6lkerungsbezogenen%20Erhebungen%20vergleichbar.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Musculoskeletal%20diseases%20and%20symptoms%20are%20very%20common%20in%20the%20general%20population.%20They%20lead%20to%20high%20healthcare%20costs%20and%20pose%20a%5Cu00a0significant%20burden%20to%20the%20national%20economy.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Objectives%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Based%20on%20data%20from%20the%20population-based%20German%20National%20Cohort%20%28GNC%29%2C%20frequencies%20of%20musculoskeletal%20symptoms%20and%20diseases%20are%20reported%2C%20including%20back%20pain%2C%20osteoporosis%2C%20osteoarthritis%2C%20and%20arthritis.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Materials%20and%20methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Data%20were%20collected%20from%20March%202014%20to%20March%202017%20in%20adults%20aged%2020%5Cu201375%5Cu00a0years%20during%20the%20first%20half%20of%20the%20baseline%20survey%20of%20the%20GNC.%20The%20sample%20comprised%20101%2C779%20interviewed%20subjects%2C%20including%209370%20subjects%20who%20underwent%20clinical%20musculoskeletal%20examinations.%20The%20interview%20included%20questions%20about%20specific%20musculoskeletal%20disorders.%20A%5Cu00a0clinical%20examination%20of%20the%20hand%20provided%20information%20about%20palpable%20swollen%20joints%20and%20pressure-sensitive%20joints.%20Resting%20pain%20of%20the%20knees%20and%20hips%20was%20also%20assessed%20by%20a%5Cu00a0clinical%20examination.%20Frequencies%20were%20standardized%20to%20the%20German%20standard%20population%20of%20the%20year%202011.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Having%20ever%20been%20diagnosed%20with%20recurrent%20back%20pain%20%2822.5%25%29%20or%20osteoarthritis%20%2820.6%25%29%20were%20the%20most%20common%20complaints%20reported%20in%20the%20interview%3B%20osteoporosis%20%282.9%25%29%20and%20rheumatoid%20arthritis%20%281.9%25%29%20were%20stated%20more%20seldom.%20According%20to%20the%20hand%20examination%2C%206.0%25%20of%20all%20participants%20experienced%20pain%20in%20at%20least%20one%20finger%20joint.%20Resting%20pain%20was%20present%20in%20at%20least%20one%20knee%20among%208.2%25%20and%20in%20at%20least%20one%20hip%20among%205.1%25%20of%20the%20participants%20as%20assessed%20during%20the%20clinical%20examination.%20Women%20were%20more%20likely%20to%20report%20musculoskeletal%20disorders%20and%20symptoms%20than%20men.%20The%20proportion%20of%20adults%20affected%20by%20musculoskeletal%20diseases%20increased%20strongly%20with%20age.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Musculoskeletal%20disorders%20and%20symptoms%20occur%20frequently.%20The%20burden%20of%20complaints%20and%20diagnoses%20is%20comparable%20to%20previous%20population-based%20surveys.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03110-1%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03110-1%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-01T13%3A50%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22HN7YJQTY%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Leube%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ELeube%20J%2C%20Zschocke%20J%2C%20Kluge%20M%2C%20et%20al.%20Reconstruction%20of%20the%20respiratory%20signal%20through%20ECG%20and%20wrist%20accelerometer%20data.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202020%3B10%281%29%3A14530.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-71539-0%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-71539-0%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reconstruction%20of%20the%20respiratory%20signal%20through%20ECG%20and%20wrist%20accelerometer%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Leube%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Zschocke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Kluge%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luise%22%2C%22lastName%22%3A%22Pelikan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonia%22%2C%22lastName%22%3A%22Graf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Glos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronny%20P.%22%2C%22lastName%22%3A%22Bartsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Penzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20W.%22%2C%22lastName%22%3A%22Kantelhardt%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Respiratory%20rate%20and%20changes%20in%20respiratory%20activity%20provide%20important%20markers%20of%20health%20and%20fitness.%20Assessing%20the%20breathing%20signal%20without%20direct%20respiratory%20sensors%20can%20be%20very%20helpful%20in%20large%20cohort%20studies%20and%20for%20screening%20purposes.%20In%20this%20paper%2C%20we%20demonstrate%20that%20long-term%20nocturnal%20acceleration%20measurements%20from%20the%20wrist%20yield%20significantly%20better%20respiration%20proxies%20than%20four%20standard%20approaches%20of%20ECG%20%28electrocardiogram%29%20derived%20respiration.%20We%20validate%20our%20approach%20by%20comparison%20with%20flow-derived%20respiration%20as%20standard%20reference%20signal%2C%20studying%20the%20full-night%20data%20of%20223%20subjects%20in%20a%20clinical%20sleep%20laboratory.%20Specifically%2C%20we%20find%20that%20phase%20synchronization%20indices%20between%20respiration%20proxies%20and%20the%20flow%20signal%20are%20large%20for%20five%20suggested%20acceleration-derived%20proxies%20with%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%24%24%5C%5Cgamma%20%3D%200.55%20%5C%5Cpm%200.13%24%24%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu03b3%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3D%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.55%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00b1%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.13%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20males%20and%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%24%240.58%20%5C%5Cpm%200.14%24%24%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.58%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00b1%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.14%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20females%20%28means%20%5Cu00b1%20standard%20deviations%29%2C%20while%20ECG-derived%20proxies%20yield%20only%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%24%24%5C%5Cgamma%20%3D%200.36%20%5C%5Cpm%200.16%24%24%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu03b3%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%3D%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.36%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00b1%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.16%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20males%20and%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%24%240.39%20%5C%5Cpm%200.14%24%24%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.39%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu00b1%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%200.14%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20for%20females.%20Similarly%2C%20respiratory%20rates%20can%20be%20determined%20more%20precisely%20by%20wrist-worn%20acceleration%20devices%20compared%20with%20a%20derivation%20from%20the%20ECG.%20As%20limitation%20we%20must%20mention%20that%20acceleration-derived%20respiration%20proxies%20are%20only%20available%20during%20episodes%20of%20non-physical%20activity%20%28especially%20during%20sleep%29.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-71539-0%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-71539-0%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-08-01T13%3A24%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22JJMMXEDY%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22K%5Cu00fcstner%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EK%26%23xFC%3Bstner%20T%2C%20Hepp%20T%2C%20Fischer%20M%2C%20et%20al.%20Fully%20Automated%20and%20Standardized%20Segmentation%20of%20Adipose%20Tissue%20Compartments%20via%20Deep%20Learning%20in%203D%20Whole-Body%20MRI%20of%20Epidemiologic%20Cohort%20Studies.%20%3Ci%3ERadiology%3A%20Artificial%20Intelligence%3C%5C%2Fi%3E.%202020%3B2%286%29%3Ae200010.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Fryai.2020200010%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1148%5C%2Fryai.2020200010%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Fully%20Automated%20and%20Standardized%20Segmentation%20of%20Adipose%20Tissue%20Compartments%20via%20Deep%20Learning%20in%203D%20Whole-Body%20MRI%20of%20Epidemiologic%20Cohort%20Studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fcstner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Hepp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Schwartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Fritsche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22H%5Cu00e4ring%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konstantin%22%2C%22lastName%22%3A%22Nikolaou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bin%22%2C%22lastName%22%3A%22Yang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fritz%22%2C%22lastName%22%3A%22Schick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergios%22%2C%22lastName%22%3A%22Gatidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Machann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1148%5C%2Fryai.2020200010%22%2C%22ISSN%22%3A%222638-6100%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fpubs.rsna.org%5C%2Fdoi%5C%2F10.1148%5C%2Fryai.2020200010%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-01T13%3A15%3A28Z%22%7D%7D%2C%7B%22key%22%3A%22XMH77CA3%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Peters%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EPeters%20A%2C%20Rospleszcz%20S%2C%20Greiser%20KH%2C%20Dallavalle%20M%2C%20Berger%20K.%20The%20Impact%20of%20the%20COVID-19%20Pandemic%20on%20Self-Reported%20Health%3A%20early%20evidence%20from%20the%20German%20National%20Cohort.%20%3Ci%3EDeutsches%20%26%23xC4%3Brzteblatt%20international%3C%5C%2Fi%3E.%202020.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.2020.0861%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.2020.0861%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Impact%20of%20the%20COVID-19%20Pandemic%20on%20Self-Reported%20Health%3A%20early%20evidence%20from%20the%20German%20National%20Cohort%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Rospleszcz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20H.%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Dallavalle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.2020.0861%22%2C%22ISSN%22%3A%221866-0452%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.aerzteblatt.de%5C%2F10.3238%5C%2Farztebl.2020.0861%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-08-01T13%3A11%3A04Z%22%7D%7D%2C%7B%22key%22%3A%227ECK8Y7L%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schipf%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ESchipf%20S%2C%20Sch%26%23xF6%3Bne%20G%2C%20Schmidt%20B%2C%20et%20al.%20Die%20Basiserhebung%20der%20NAKO%20Gesundheitsstudie%3A%20Teilnahme%20an%20den%20Untersuchungsmodulen%2C%20Qualit%26%23xE4%3Btssicherung%20und%20Nutzung%20von%20Sekund%26%23xE4%3Brdaten.%20%3Ci%3EBundesgesundheitsbl%3C%5C%2Fi%3E.%202020%3B63%283%29%3A254-266.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03093-z%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03093-z%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Die%20Basiserhebung%20der%20NAKO%20Gesundheitsstudie%3A%20Teilnahme%20an%20den%20Untersuchungsmodulen%2C%20Qualit%5Cu00e4tssicherung%20und%20Nutzung%20von%20Sekund%5Cu00e4rdaten%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gina%22%2C%22lastName%22%3A%22Sch%5Cu00f6ne%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gunthard%22%2C%22lastName%22%3A%22St%5Cu00fcbs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20H.%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Bamberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Meinke-Franze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiko%22%2C%22lastName%22%3A%22Becher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefanie%22%2C%22lastName%22%3A%22Castell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antje%22%2C%22lastName%22%3A%22Damms-Machado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus-Werner%22%2C%22lastName%22%3A%22Franzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Fricke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22G%5Cu00fcnther%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bernd%22%2C%22lastName%22%3A%22Holleczek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Jagodzinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Ulrich%22%2C%22lastName%22%3A%22Kauczor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00e4rbel%22%2C%22lastName%22%3A%22Kurth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Ku%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Legath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mikolajczyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Iris%22%2C%22lastName%22%3A%22Pigeot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Mueller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tamara%22%2C%22lastName%22%3A%22Schikowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%20B.%22%2C%22lastName%22%3A%22Schulze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Stallmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Stang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enno%22%2C%22lastName%22%3A%22Swart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Waniek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%22%2C%22lastName%22%3A%22V%5Cu00f6lzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%5D%2C%22abstractNote%22%3A%22Zusammenfassung%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Hintergrund%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20NAKO%20Gesundheitsstudie%20ist%20ein%20bundesweites%20interdisziplin%5Cu00e4res%20Forschungsvorhaben%20mit%20dem%20Ziel%2C%20die%20Ursachen%20f%5Cu00fcr%20chronische%20Krankheiten%20und%20deren%20vorklinische%20Stadien%20zu%20untersuchen.%20Der%20Artikel%20gibt%20einen%20%5Cu00dcberblick%20%5Cu00fcber%20das%20Studiendesign%2C%20die%20Methoden%2C%20die%20Teilnahme%20an%20den%20Untersuchungen%20und%20ihre%20Qualit%5Cu00e4tssicherung%20zur%20Halbzeit%20der%20Basiserhebung.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methoden%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20F%5Cu00fcr%20die%20Basiserhebung%20wurden%20mehr%20als%20200.000%20Frauen%20und%20M%5Cu00e4nner%20im%20Alter%20von%2020%5Cu201369%5Cu00a0Jahren%20aus%20Zufallsstichproben%20der%20Allgemeinbev%5Cu00f6lkerung%20in%2018%5Cu00a0Studienzentren%20rekrutiert%20%282014%5Cu20132019%29.%20Die%20Basiserhebung%20beinhaltet%20Untersuchungen%2C%20Befragungen%20und%20Biomaterialien%20f%5Cu00fcr%20alle%20Teilnehmerinnen%20und%20Teilnehmer%20%28Level%5Cu00a01%29%2C%20ein%20erweitertes%20Programm%20f%5Cu00fcr%20mindestens%2020%5Cu202f%25%20%28Level%5Cu00a02%29%20und%20eine%20Magnetresonanztomografie%20%28MRT%29%20f%5Cu00fcr%2030.000%20Teilnehmerinnen%20und%20Teilnehmer.%20Sekund%5Cu00e4r-%20und%20Registerdaten%20werden%20%5Cu00fcber%20Krankheitsregister%2C%20Kranken-%20und%20Rentenversicherungen%20erhoben.%20Die%20Auswertung%20bezieht%20die%20Datenbasis%20zur%20Halbzeit%20der%20Basiserhebung%20mit%20101.839%20Teilnehmerinnen%20und%20Teilnehmern%20ein%2C%20davon%2011.371%20mit%20einer%20MRT-Untersuchung.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Ergebnisse%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20mittlere%20Responsequote%20zur%20Halbzeit%20betrug%20insgesamt%2018%5Cu202f%25.%20Die%20Teilnahme%20an%20den%20Untersuchungen%20lag%20%5Cu00fcberwiegend%20bei%20mehr%20als%2095%5Cu202f%25.%20Bei%2096%5Cu202f%25%20der%20MRT-Teilnehmerinnen%20und%20Teilnehmer%20konnten%20alle%2012%5Cu00a0MRT-Sequenzen%20vollst%5Cu00e4ndig%20durchgef%5Cu00fchrt%20werden.%20Der%20Erschlie%5Cu00dfung%20und%20wissenschaftlichen%20Nutzung%20erg%5Cu00e4nzender%20Sekund%5Cu00e4r-%20und%20Registerdaten%20stimmten%20mehr%20als%2090%5Cu202f%25%20der%20Teilnehmerinnen%20und%20Teilnehmer%20zu.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Diskussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Die%20Bereitschaft%2C%20m%5Cu00f6glichst%20alle%20Untersuchungsmodule%20durchzuf%5Cu00fchren%2C%20war%20trotz%20des%20zeitlichen%20Aufwandes%20au%5Cu00dferordentlich%20hoch.%20Dadurch%20wird%20die%20NAKO%20zu%20einer%20zentralen%20Ressource%20f%5Cu00fcr%20die%20epidemiologische%20Forschung%20in%20Deutschland.%20Sie%20wird%20es%20erm%5Cu00f6glichen%2C%20neue%20Strategien%20zur%20Fr%5Cu00fcherkennung%2C%20Vorhersage%20und%20Prim%5Cu00e4rpr%5Cu00e4vention%20chronischer%20Krankheiten%20zu%20entwickeln.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%2C%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20Abstract%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20German%20National%20Cohort%20%28NAKO%29%20is%20an%20interdisciplinary%20health%20study%20aimed%20at%20elucidating%20causes%20for%20common%20chronic%20diseases%20and%20detecting%20their%20preclinical%20stages.%20This%20article%20provides%20an%20overview%20of%20design%2C%20methods%2C%20participation%20in%20the%20examinations%2C%20and%20their%20quality%20assurance%20based%20on%20the%20midterm%20baseline%20dataset%20%28MBD%29%20of%20the%20recruitment.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20More%20than%20200%2C000%20women%20and%20men%20aged%2020%5Cu201369%5Cu00a0years%20derived%20from%20random%20samples%20of%20the%20German%20general%20population%20were%20recruited%20in%2018%5Cu00a0study%20centers%20%282014%5Cu20132019%29.%20The%20data%20collection%20comprised%20physical%20examinations%2C%20standardized%20interviews%20and%20questionnaires%2C%20and%20the%20collection%20of%20biomedical%20samples%20for%20all%20participants%20%28level%5Cu00a01%29.%20At%20least%2020%25%20of%20all%20participants%20received%20additional%20in-depth%20examinations%20%28level%5Cu00a02%29%2C%20and%2030%2C000%20received%5Cu00a0whole-body%20magnet%20resonance%20imaging%20%28MRI%29.%20Additional%20information%20will%20be%20collected%20through%20secondary%20data%20sources%20such%20as%20medical%20registries%2C%20health%20insurances%2C%20and%20pension%20funds.%20This%20overview%20is%20based%20on%20the%20MBD%2C%20which%20included%20101%2C839%20participants%2C%20of%20whom%2011%2C371%20received%20an%20MRI.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20mean%20response%20proportion%20was%2018%25.%20The%20participation%20in%20the%20examinations%20was%20high%20with%20most%20of%20the%20modules%20performed%20by%20over%2095%25.%20Among%20MRI%20participants%2C%2096%25%20completed%20all%2012%5Cu00a0MRI%20sequences.%20More%20than%2090%25%20of%20the%20participants%20agreed%20to%20the%20use%20of%20complementary%20secondary%20and%20registry%20data.%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Individuals%20selected%20for%20the%20NAKO%20were%20willing%20to%20participate%20in%20all%20examinations%20despite%20the%20time-consuming%20program.%20The%20NAKO%20provides%20a%5Cu00a0central%20resource%20for%20population-based%20epidemiologic%20research%20and%20will%20contribute%20to%20developing%20innovative%20strategies%20for%20prevention%2C%20screening%20and%20prediction%20of%20chronic%20diseases.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22de%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03093-z%22%2C%22ISSN%22%3A%221436-9990%2C%201437-1588%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Flink.springer.com%5C%2F10.1007%5C%2Fs00103-020-03093-z%22%2C%22collections%22%3A%5B%223PFDINQ6%22%5D%2C%22dateModified%22%3A%222024-07-31T13%3A11%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22UNVQIHQY%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stogbauer%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EStogbauer%20J%2C%20Wirkner%20K%2C%20Engel%20C%2C%20et%20al.%20Prevalence%20and%20risk%20factors%20of%20smell%20dysfunction%20-%20a%20comparison%20between%20five%20German%20population-based%20studies.%20%3Ci%3ERhin%3C%5C%2Fi%3E.%202020%3B0%280%29%3A0-0.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4193%5C%2FRhin19.181%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.4193%5C%2FRhin19.181%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prevalence%20and%20risk%20factors%20of%20smell%20dysfunction%20-%20a%20comparison%20between%20five%20German%20population-based%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.%22%2C%22lastName%22%3A%22Stogbauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Wirkner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Engel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Moebus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Pundt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.%22%2C%22lastName%22%3A%22Teismann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Loffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.%22%2C%22lastName%22%3A%22Hummel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.G.%22%2C%22lastName%22%3A%22Beule%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.%22%2C%22lastName%22%3A%22Berger%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.4193%5C%2FRhin19.181%22%2C%22ISSN%22%3A%2203000729%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.rhinologyjournal.com%5C%2FAbstract.php%3Fid%3D2194%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-24T14%3A49%3A22Z%22%7D%7D%2C%7B%22key%22%3A%22GI7UHGQI%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Morawa%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EMorawa%20E%2C%20Brand%20T%2C%20Dragano%20N%2C%20J%26%23xF6%3Bckel%20KH%2C%20Moebus%20S%2C%20Erim%20Y.%20Associations%20Between%20Acculturation%2C%20Depressive%20Symptoms%2C%20and%20Life%20Satisfaction%20Among%20Migrants%20of%20Turkish%20Origin%20in%20Germany%3A%20Gender-%20and%20Generation-Related%20Aspects.%20%3Ci%3EFront%20Psychiatry%3C%5C%2Fi%3E.%202020%3B11%3A715.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffpsyt.2020.00715%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffpsyt.2020.00715%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20Between%20Acculturation%2C%20Depressive%20Symptoms%2C%20and%20Life%20Satisfaction%20Among%20Migrants%20of%20Turkish%20Origin%20in%20Germany%3A%20Gender-%20and%20Generation-Related%20Aspects%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Morawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tilman%22%2C%22lastName%22%3A%22Brand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nico%22%2C%22lastName%22%3A%22Dragano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22Moebus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yesim%22%2C%22lastName%22%3A%22Erim%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffpsyt.2020.00715%22%2C%22ISSN%22%3A%221664-0640%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticle%5C%2F10.3389%5C%2Ffpsyt.2020.00715%5C%2Ffull%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-24T14%3A20%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22MXDDVWSD%22%2C%22library%22%3A%7B%22id%22%3A5565830%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jaeschke%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%201.35%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%20%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EJaeschke%20L%2C%20Steinbrecher%20A%2C%20Boeing%20H%2C%20et%20al.%20Factors%20associated%20with%20habitual%20time%20spent%20in%20different%20physical%20activity%20intensities%20using%20multiday%20accelerometry.%20%3Ci%3ESci%20Rep%3C%5C%2Fi%3E.%202020%3B10%281%29%3A774.%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-57648-w%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-57648-w%3C%5C%2Fa%3E%3C%5C%2Fdiv%3E%5Cn%20%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Factors%20associated%20with%20habitual%20time%20spent%20in%20different%20physical%20activity%20intensities%20using%20multiday%20accelerometry%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lina%22%2C%22lastName%22%3A%22Jaeschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Astrid%22%2C%22lastName%22%3A%22Steinbrecher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heiner%22%2C%22lastName%22%3A%22Boeing%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvia%22%2C%22lastName%22%3A%22Gastell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Ahrens%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hermann%22%2C%22lastName%22%3A%22Brenner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Ebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Fischer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20Halina%22%2C%22lastName%22%3A%22Greiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl-Heinz%22%2C%22lastName%22%3A%22J%5Cu00f6ckel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rudolf%22%2C%22lastName%22%3A%22Kaaks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Keil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yvonne%22%2C%22lastName%22%3A%22Kemmling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexander%22%2C%22lastName%22%3A%22Kluttig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lilian%22%2C%22lastName%22%3A%22Krist%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Leitzmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Lieb%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jakob%22%2C%22lastName%22%3A%22Linseisen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22L%5Cu00f6ffler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karin%20B.%22%2C%22lastName%22%3A%22Michels%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadia%22%2C%22lastName%22%3A%22Obi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Peters%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Schipf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B%5Cu00f6rge%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melanie%22%2C%22lastName%22%3A%22Zinkhan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%22%2C%22lastName%22%3A%22Pischon%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20To%20investigate%20factors%20associated%20with%20time%20in%20physical%20activity%20intensities%2C%20we%20assessed%20physical%20activity%20of%20249%20men%20and%20women%20%28mean%20age%2051.3%20years%29%20by%207-day%2024h-accelerometry%20%28ActiGraph%20GT3X%2B%29.%20Triaxial%20vector%20magnitude%20counts%5C%2Fminute%20were%20extracted%20to%20determine%20time%20in%20inactivity%2C%20in%20low-intensity%2C%20moderate%2C%20and%20vigorous-to-very-vigorous%20activity.%20Cross-sectional%20associations%20with%20sex%2C%20age%2C%20body%20mass%20index%2C%20waist%20circumference%2C%20smoking%2C%20alcohol%20consumption%2C%20education%2C%20employment%2C%20income%2C%20marital%20status%2C%20diabetes%2C%20and%20dyslipidaemia%20were%20investigated%20in%20multivariable%20regression%20analyses.%20Higher%20age%20was%20associated%20with%20more%20time%20in%20low-intensity%20%28mean%20difference%2C%207.3%5Cu2009min%5C%2Fd%20per%205%20years%3B%2095%25%20confidence%20interval%202.0%2C12.7%29%20and%20less%20time%20in%20vigorous-to-very-vigorous%20activity%20%28%5Cu22120.8%5Cu2009min%5C%2Fd%3B%20%5Cu22121.4%2C%20%5Cu22120.2%29%2C%20while%20higher%20BMI%20was%20related%20to%20less%20time%20in%20low-intensity%20activity%20%28%5Cu22123.7%5Cu2009min%5C%2Fd%3B%20%5Cu22126.3%2C%20%5Cu22121.2%29.%20Current%20versus%20never%20smoking%20was%20associated%20with%20more%20time%20in%20low-intensity%20%2829.2%5Cu2009min%5C%2Fd%3B%207.5%2C%2050.9%29%20and%20less%20time%20in%20vigorous-to-very-vigorous%20activity%20%28%5Cu22123.9%5Cu2009min%5C%2Fd%3B%20%5Cu22126.3%2C%20%5Cu22121.5%29.%20Finally%2C%20having%20versus%20not%20having%20a%20university%20entrance%20qualification%20and%20being%20not%20versus%20full%20time%20employed%20were%20associated%20with%20more%20inactivity%20time%20%2835.9%5Cu2009min%5C%2Fd%3B%2013.0%2C%2058.8%2C%20and%2066.2%5Cu2009min%5C%2Fd%3B%2034.7%2C%2097.7%2C%20respectively%29%20and%20less%20time%20in%20low-intensity%20activity%20%28%5Cu221231.7%5Cu2009min%5C%2Fd%3B%20%5Cu221249.9%2C%20%5Cu221213.4%2C%20and%20%5Cu221250.7%3B%20%5Cu221276.6%2C%20%5Cu221224.8%2C%20respectively%29.%20The%20assessed%20factors%20show%20distinct%20associations%20with%20activity%20intensities%2C%20providing%20targets%20for%20public%20health%20measures%20aiming%20to%20increase%20activity.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-57648-w%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-57648-w%22%2C%22collections%22%3A%5B%22BXDKHVX6%22%5D%2C%22dateModified%22%3A%222024-07-24T14%3A05%3A57Z%22%7D%7D%5D%7D
1.
Fischer B, Sedlmeier AM, Hartwig S, et al. Anthropometrische Messungen in der NAKO Gesundheitsstudie – mehr als nur Größe und Gewicht. Bundesgesundheitsbl. 2020;63(3):290-300. http://doi.org/10.1007/s00103-020-03096-w
1.
Hassenstein MJ, Aarabi G, Ahnert P, et al. Selbst berichtete Infektionen in der NAKO Gesundheitsstudie – Einordnung in die gegenwärtige Forschungslandschaft. Bundesgesundheitsbl. 2020;63(4):404-414. http://doi.org/10.1007/s00103-020-03114-x
1.
Hepp T, Fischer M, Winkelmann MT, et al. Fully Automated Segmentation and Shape Analysis of the Thoracic Aorta in Non–contrast-enhanced Magnetic Resonance Images of the German National Cohort Study. Journal of Thoracic Imaging. 2020;35(6):389-398. http://doi.org/10.1097/RTI.0000000000000522
1.
Holtfreter B, Samietz S, Hertrampf K, et al. Design und Qualitätskontrolle der zahnmedizinischen Untersuchung in der NAKO Gesundheitsstudie. Bundesgesundheitsbl. 2020;63(4):426-438. http://doi.org/10.1007/s00103-020-03107-w
1.
Jaeschke L, Steinbrecher A, Greiser KH, et al. Erfassung selbst berichteter kardiovaskulärer und metabolischer Erkrankungen in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse. Bundesgesundheitsbl. 2020;63(4):439-451. http://doi.org/10.1007/s00103-020-03108-9
1.
Karrasch S, Peters A, Meisinger C, et al. Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse. Bundesgesundheitsbl. 2020;63(3):322-331. http://doi.org/10.1007/s00103-020-03102-1
1.
Kluttig A, Zschocke J, Haerting J, et al. Messung der körperlichen Fitness in der NAKO Gesundheitsstudie – Methoden, Qualitätssicherung und erste deskriptive Ergebnisse. Bundesgesundheitsbl. 2020;63(3):312-321. http://doi.org/10.1007/s00103-020-03100-3
1.
Kraus FB, Kocijancic M, Kluttig A, Ludwig-Kraus B. Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples. Biochem med (Online). 2020;30(1):118-127. http://doi.org/10.11613/BM.2020.010707
1.
Langer S, Horn J, Kluttig A, et al. Häufigkeit von Asthma bronchiale und Alter bei der Erstdiagnose – erste Ergebnisse der NAKO Gesundheitsstudie. Bundesgesundheitsbl. 2020;63(4):397-403. http://doi.org/10.1007/s00103-020-03105-y
1.
Leitzmann M, Gastell S, Hillreiner A, et al. Körperliche Aktivität in der NAKO Gesundheitsstudie: erste Ergebnisse des multimodalen Erhebungskonzepts. Bundesgesundheitsbl. 2020;63(3):301-311. http://doi.org/10.1007/s00103-020-03099-7
1.
Lieb W, Vasan RS. An update on genetic risk scores for coronary artery disease: are they useful for predicting disease risk and guiding clinical decisions? Expert Review of Cardiovascular Therapy. 2020;18(8):443-447. http://doi.org/10.1080/14779072.2020.1797489
1.
Nimptsch K, Jaeschke L, Chang-Claude J, et al. Selbstberichtete Krebserkrankungen in der NAKO Gesundheitsstudie: Erfassungsmethoden und erste Ergebnisse. Bundesgesundheitsbl. 2020;63(4):385-396. http://doi.org/10.1007/s00103-020-03113-y
1.
Rach S, Günther K, Hadeler B. Participants who were difficult to recruit at baseline are less likely to complete a follow-up questionnaire – results from the German National Cohort. BMC Med Res Methodol. 2020;20(1):187. http://doi.org/10.1186/s12874-020-01073-0
1.
Schikowski T, Wigmann C, Fuks KB, et al. Blutdruckmessung in der NAKO – methodische Unterschiede, Blutdruckverteilung und Bekanntheit der Hypertonie im Vergleich zu anderen bevölkerungsbezogenen Studien in Deutschland. Bundesgesundheitsbl. 2020;63(4):452-464. http://doi.org/10.1007/s00103-020-03109-8
1.
Wiessner C, Keil T, Krist L, et al. Personen mit Migrationshintergrund in der NAKO Gesundheitsstudie – soziodemografische Merkmale und Vergleiche mit der autochthonen deutschen Bevölkerung. Bundesgesundheitsbl. 2020;63(3):279-289. http://doi.org/10.1007/s00103-020-03097-9
1.
Winter T, Friedrich N, Lamp S, et al. The Integrated Research Biobank of the University Medicine Greifswald. Open Journal of Bioresources. 2020;7:2. http://doi.org/10.5334/ojb.64
1.
Wolf K, Kraus U, Dzolan M, et al. Nächtliche Verkehrslärmbelästigung in Deutschland: individuelle und regionale Unterschiede in der NAKO Gesundheitsstudie. Bundesgesundheitsbl. 2020;63(3):332-343. http://doi.org/10.1007/s00103-020-03094-y
1.
Dragano N, Reuter M, Greiser KH, et al. Soziodemografische und erwerbsbezogene Merkmale in der NAKO Gesundheitsstudie. Bundesgesundheitsbl. 2020;63(3):267-278. http://doi.org/10.1007/s00103-020-03098-8
1.
Ahrens W, Pigeot I, Pischon T. Das Fundament ist gelegt – für verbesserte Vorbeugung und Früherkennung der großen Volkskrankheiten. Bundesgesundheitsbl. 2020;63(4):373-375. http://doi.org/10.1007/s00103-020-03119-6
1.
Ahrens W, Pigeot I, Pischon T. Was macht krank, was hält uns gesund? Bundesgesundheitsbl. 2020;63(3):251-253. http://doi.org/10.1007/s00103-020-03104-z
1.
Ahrens W, Greiser KH, Linseisen J, Pischon T, Pigeot I. Erforschung von Erkrankungen in der NAKO Gesundheitsstudie. Die wichtigsten gesundheitlichen Endpunkte und ihre Erfassung. Bundesgesundheitsbl. 2020;63(4):376-384. http://doi.org/10.1007/s00103-020-03111-0
1.
Zeeb H, Dreger S. Medizinische Strahlenexposition in der NAKO Gesundheitsstudie - Vorhaben 3616S42233. 2020. http://doris.bfs.de/jspui/bitstream/urn:nbn:de:0221-2020050821816/3/BfS_2020_3616S42233.pdf.
1.
Schmidt CO, Günther KP, Goronzy J, et al. Häufigkeiten muskuloskelettaler Symptome und Erkrankungen in der bevölkerungsbezogenen NAKO Gesundheitsstudie. Bundesgesundheitsbl. 2020;63(4):415-425. http://doi.org/10.1007/s00103-020-03110-1
1.
Leube J, Zschocke J, Kluge M, et al. Reconstruction of the respiratory signal through ECG and wrist accelerometer data. Sci Rep. 2020;10(1):14530. http://doi.org/10.1038/s41598-020-71539-0
1.
Küstner T, Hepp T, Fischer M, et al. Fully Automated and Standardized Segmentation of Adipose Tissue Compartments via Deep Learning in 3D Whole-Body MRI of Epidemiologic Cohort Studies. Radiology: Artificial Intelligence. 2020;2(6):e200010. http://doi.org/10.1148/ryai.2020200010
1.
Peters A, Rospleszcz S, Greiser KH, Dallavalle M, Berger K. The Impact of the COVID-19 Pandemic on Self-Reported Health: early evidence from the German National Cohort. Deutsches Ärzteblatt international. 2020. http://doi.org/10.3238/arztebl.2020.0861
1.
Schipf S, Schöne G, Schmidt B, et al. Die Basiserhebung der NAKO Gesundheitsstudie: Teilnahme an den Untersuchungsmodulen, Qualitätssicherung und Nutzung von Sekundärdaten. Bundesgesundheitsbl. 2020;63(3):254-266. http://doi.org/10.1007/s00103-020-03093-z
1.
Stogbauer J, Wirkner K, Engel C, et al. Prevalence and risk factors of smell dysfunction - a comparison between five German population-based studies. Rhin. 2020;0(0):0-0. http://doi.org/10.4193/Rhin19.181
1.
Morawa E, Brand T, Dragano N, Jöckel KH, Moebus S, Erim Y. Associations Between Acculturation, Depressive Symptoms, and Life Satisfaction Among Migrants of Turkish Origin in Germany: Gender- and Generation-Related Aspects. Front Psychiatry. 2020;11:715. http://doi.org/10.3389/fpsyt.2020.00715
1.
Jaeschke L, Steinbrecher A, Boeing H, et al. Factors associated with habitual time spent in different physical activity intensities using multiday accelerometry. Sci Rep. 2020;10(1):774. http://doi.org/10.1038/s41598-020-57648-w
5565830
2019,2018,2017,2016,2015,2014,2012
1
american-medical-association-10th-edition
50
date
desc
1
51
https://nako.de/wp-content/plugins/zotpress/