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Expert groups

Biomaterials and laboratory analyses

Project goals

The combination of biosamples with detailed data from medical examinations and interviews offers great potential for research. The collected biosamples can be used to determine a variety of biomarkers to indicate normal or pathological processes in the body. The aim is to develop new diagnostic procedures and approaches for prevention and therapy.

In the German National Cohort (NAKO), samples from around 205,000 participants are processed and stored for the long term.

Tasks:

  • Creation of standardised protocols (SOPs) for the professional collection of biomaterials and their pre-analytical handling
  • Automation of sample processing and
    transfer of results through laboratory information systems
  • Quality control, quality assurance, preparation of immediate analysis data and sample processing data for biobanking
  • Establishment of a centralised study laboratory for NAKO immediate analysis
  • Planning, project planning, monitoring, process optimisation of biobanking in local and central repositories
  • Support in the evaluation of immediate analysis data in the context of publications other research groups

 

First results

The current publications deal with the further development of the methods.

Publications

Winter T, Friedrich N, Lamp S, et al. The Integrated Research Biobank of the University Medicine Greifswald. Open Journal of Bioresources. 2020;7:2. http://doi.org/10.5334/ojb.64

Petersmann A, Winter T, Lamp S, Nauck M. Relevant criteria for the selection of cryotubes. Experiences from the German National Cohort. Journal of Laboratory Medicine. 2019;43(6):339-345. http://doi.org/10.1515/labmed-2019-0172

Budde K, Gök ÖN, Pietzner M, et al. Quality assurance in the pre-analytical phase of human urine samples by 1H NMR spectroscopy. Archives of Biochemistry and Biophysics. 2016;589:10-17. http://doi.org/10.1016/j.abb.2015.07.016

Wichmann HE, Hörlein A, Ahrens W, Nauck M. Die Biobank der Nationalen Kohorte als Ressource der epidemiologischen Forschung. Bundesgesundheitsbl. 2016;59(3):351-360. http://doi.org/10.1007/s00103-015-2305-4

 

Speakers

Prof. Dr. Matthias Nauck
Dr. Kathrin Günther (Deputy Spokesperson)